Article Figures & Data
Figures
- Fig 1.
The top row of images shows cerebral blood flow (intensity-normalized units), arterial transit time, large-artery transit time, and arterial blood volume (arbitrary units) from a representative participant. In the ATT image, the posterior circulation tends to have a longer ATT compared with the middle cerebral artery vascular territory. LATT and arterial blood volume are macrovascular measures that are estimated from voxels containing large-artery/intravascular ASL signal. The bottom row shows 4 lobe-based regions of interest chosen for ATT (and CBF) analysis, while a middle cerebral artery/insula region of interest was chosen the LATT analysis.
- Fig 2.
Voxelwise results from the regression analyses in which the vascular model (“pressor” and “obesity” factor) was used as an independent factor that influences ATT. The obesity factor produced a negative association with ATT, in the sense that the higher the BMI and/or body fat, the shorter the ATT. Significant voxels in red and yellow are corrected for multiple comparison (pcorrected = .05).
- Fig 3.
Voxelwise results from the regression analyses, in which the cognitive model was used as an independent factor that influences ATT. The first cognitive factor (ie, characterized by poor cognitive performance) was positively associated with ATT, in the sense that a lower cognitive score was associated with a shorter ATT. Significant voxels in blue and cyan are corrected for multiple comparison (pcorrected = .05).
Tables
Demographic Mean (SD) Minimum Maximum Age (yr) 65 (7) 55 78 BMI (kg/m2) 28.2 (3.9) 20.5 35.3 Body fat (%) 26.0 (5.9) 13.3 38.7 SBP (mm Hg) 124 (15.4) 94.0 152.0 PP (mm Hg) 51 (13.0) 24.0 80.0 Note:—PP indicates pulse pressure.
Correlation Coefficient (r) Component 1 Component 2 Component 3 Vascular model Age (yr) −0.65 0.32 0.69 BMI (kg/m2) 0.23 0.91 −0.06 Body fat (%) 0.24 0.91 −0.10 SBP (mm Hg) −0.90 0.18 −0.32 PP (mm Hg) −0.94 0.06 −0.21 Percentage of variance (%) Explained variance 0.45 0.36 0.13 Cumulative variance 0.45 0.81 0.94 Cognitive model Age (yr) 0.48 0.76 −0.39 CVLT-LDFR −0.73 −0.37 −0.50 Digit symbol-coding −0.70 0.53 0.30 Stroop 0.85 −0.06 −0.16 TMT B 0.82 −0.26 0.21 Percentage of variance (%) Explained variance 0.53 0.21 0.11 Note:—TMT indicates Trail-Making Test; PP, pulse pressure.
No. of Voxels MNI Coordinates X Y Z Vascular model 1) Lateral occipital, R 540 −33 −78 30 2) Lateral occipital, L 38 39 −69 27 3) Middle temporal gyrus, R 36 54 −57 6 4) Precuneus 13 0 −60 60 5) Frontal pole, L 11 −36 45 18 6) Angular gyrus, L 11 −39 −51 42 7) Lateral occipital, L 4 −27 −63 48 Cognitive model 1) Precuneus 189 0 −66 42 Note:—MNI indicates Montreal Neurological Institute; R, right; L, left.
