Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Increased Number of White Matter Lesions in Patients with Familial Cerebral Cavernous Malformations

M.J. Golden, L.A. Morrison, H. Kim and B.L. Hart
American Journal of Neuroradiology May 2015, 36 (5) 899-903; DOI: https://doi.org/10.3174/ajnr.A4200
M.J. Golden
aFrom the Departments of Radiology (M.J.G., B.L.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L.A. Morrison
bNeurology (L.A.M.), University of New Mexico, Albuquerque, New Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. Kim
cDepartments of Anesthesiology and Perioperative Care (H.K.)
dEpidemiology and Biostatistics (H.K.), University of California, San Francisco, San Francisco, California.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.L. Hart
aFrom the Departments of Radiology (M.J.G., B.L.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. Rivera PP,
    2. Willinsky RA,
    3. Porter PJ
    . Intracranial cavernous malformations. Neuroimaging Clin N Am 2003;13:27–40
    CrossRefPubMed
  2. 2.↵
    1. Kattapong VJ,
    2. Hart BL,
    3. Davis LE
    . Familial cerebral cavernous angiomas: clinical and radiologic studies. Neurology 1995;45:492–97
    CrossRef
  3. 3.↵
    1. Gunel M,
    2. Awad IA,
    3. Finberg K, et al
    . A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans. N Engl J Med 1996;334:946–51
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Zabramski JM,
    2. Wascher TM,
    3. Spetzler RF, et al
    . The natural history of familial cavernous malformations: results of an ongoing study. J Neurosurg 1994;80:422–32
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Akers AL,
    2. Ball KL,
    3. Clancy M, et al
    . Brain vascular malformation consortium: overview, progress and future directions. J Rare Disord 2013;1:5
    PubMed
  6. 6.↵
    1. Christiansen P,
    2. Larsson HB,
    3. Thomsen C, et al
    . Age dependent white matter lesions and brain volume changes in healthy volunteers. Acta Radiol 1994;35:117–22
    Abstract/FREE Full Text
  7. 7.↵
    1. Vernooij MW,
    2. Ikram MA,
    3. Tanghe HL, et al
    . Incidental findings on brain MRI in the general population. N Engl J Med 2007;357:1821–28
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Osborn AG
    . Osborn's Brain: Imaging, Pathology, and Anatomy. Salt Lake City: Amirsys; 2012
  9. 9.↵
    1. Liao D,
    2. Cooper L,
    3. Cai J, et al
    . Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control: the ARIC Study—Atherosclerosis Risk in Communities Study. Stroke 1996;27:2262–70
    Abstract/FREE Full Text
  10. 10.↵
    1. Hopkins RO,
    2. Beck CJ,
    3. Burnett DL, et al
    . Prevalence of white matter hyperintensities in a young healthy population. J Neuroimaging 2006;16:243–51
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Katzman GL,
    2. Dagher AP,
    3. Patronas NJ
    . Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA 1999;282:36–39
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Eriksson SH,
    2. Stepney A,
    3. Symms MR, et al
    . Ultra-fast low-angle rapid acquisition and relaxation enhancement (UFLARE) in patients with epilepsy. Neuroradiology 2001;43:1040–45
    CrossRefPubMed
  13. 13.↵
    1. Jansen JFA,
    2. Vlooswijk MC,
    3. Majoie HM, et al
    . White matter lesions in patients with localization-related epilepsy. Invest Radiol 2008;43:552–58
    CrossRefPubMed
  14. 14.↵
    1. Wieshmann UC
    . Clinical application of neuroimaging in epilepsy. J Neurol Neurosurg Psychiatry 2003;74:466–70
    Abstract/FREE Full Text
  15. 15.↵
    1. Stockton RA,
    2. Shenkar R,
    3. Awad IA, et al
    . Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med 2010;207:881–96
    Abstract/FREE Full Text
  16. 16.↵
    1. Glading A,
    2. Han J,
    3. Stockton RA, et al
    . KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol 2007;179:247–54
    Abstract/FREE Full Text
  17. 17.↵
    1. Schneider H,
    2. Errede M,
    3. Ulrich NH, et al
    . Impairment of tight junctions and glucose transport in endothelial cells of human cerebral cavernous malformations. J Neuropathol Exp Neurol 2011;70:417–29
    CrossRefPubMed
  18. 18.↵
    1. Tu J,
    2. Stoodley MA,
    3. Morgan MK, et al
    . Ultrastructural characteristics of hemorrhagic, nonhemorrhagic, and recurrent cavernous malformations. J Neurosurg 2005;103:903–09
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Clatterbuck RE,
    2. Eberhart CG,
    3. Crain BJ, et al
    . Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations. J Neurol Neurosurg Psychiatry 2001;71:188–92
    Abstract/FREE Full Text
  20. 20.↵
    1. Hart BL,
    2. Taheri S,
    3. Rosenberg GA, et al
    . Dynamic contrast-enhanced MRI evaluation of cerebral cavernous malformations. Trans Stroke Res 2013;4:500–06
    CrossRef
  21. 21.↵
    1. Young VG,
    2. Halliday GM,
    3. Kril JJ
    . Neuropathologic correlates of white matter hyperintensities. Neurology 2008;71:804–11
    CrossRef
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 36 (5)
American Journal of Neuroradiology
Vol. 36, Issue 5
1 May 2015
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Increased Number of White Matter Lesions in Patients with Familial Cerebral Cavernous Malformations
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M.J. Golden, L.A. Morrison, H. Kim, B.L. Hart
Increased Number of White Matter Lesions in Patients with Familial Cerebral Cavernous Malformations
American Journal of Neuroradiology May 2015, 36 (5) 899-903; DOI: 10.3174/ajnr.A4200

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Increased Number of White Matter Lesions in Patients with Familial Cerebral Cavernous Malformations
M.J. Golden, L.A. Morrison, H. Kim, B.L. Hart
American Journal of Neuroradiology May 2015, 36 (5) 899-903; DOI: 10.3174/ajnr.A4200
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
  • Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire