Article Figures & Data
Figures
- Fig 1.
As an example, in patient 5, a conventional DSA sequence at 5 time instances shows the course of CM passing through the aortic arch and its major branching arteries (A). In the generated CCQ-DSA image, ROIs are defined on bilateral CCAs as red (ROI-R) and green (ROI-L) rectangles (B). Corresponding TDCs were extracted from the defined ROI, showing good correlation between the 2 curves (C). On the CBV maps (D), 3 planes were selected (upper panel). The lower panel corresponded to the above planes (left, plane 1; middle, plane 2; right, plane 3), with ROIs defined in pairs (ROI-R on the right hemisphere and ROI-L on the left hemisphere) on each plane covering characteristic anatomic structures to examine rCBV on 2 hemispheres: the frontal and parietal lobes in plane 1; frontal lobe and basal ganglia region in plane 2; and temporal lobe in plane 3.
- Fig 2.
As an example, in patient 11, conventional DSA sequence at 5 time instances shows the course of CM passing through the aortic arch and its major branching arteries (A). In the generated CCQ-DSA image, ROIs were defined on bilateral CCAs (B). Corresponding TDCs were extracted from the defined ROIs, showing large deviations in magnitude between the 2 curves (C). CBV maps evidently show low perfusion levels in plane 1 (lower panel, left) in the parietal lobe, in plane 2 (lower panel, middle) in both the frontal lobe and basal ganglia region, and in plane 3 (lower panel, right) in the temporal lobe (D).
- Fig 3.
Linear regression analysis shows that rAUC and rCBV with the most asymmetry have approximately a linear relationship.
Tables
Patient No. Age (yr) Sex DSA Diagnosis Treatment 1 35 Female Left internal carotid artery aneurysm Stent-assisted coiling 2 49 Male Left internal carotid artery aneurysm Medication 3 46 Male Sagittal sinus thrombus Medication 4 43 Male Sellar mass – 5 54 Female Subarachnoid hemorrhage Medication 6 47 Male Further investigation needed Medication 7 50 Male Mild stenosis on right vertebral artery – 8 49 Male Further investigation needed – 9 37 Male Further investigation needed Medication 10 67 Male Hemorrhage on left occipital lobe Medication 11 51 Female Further investigation needed – 12 64 Female Glomus jugulare tumor Medication + lumbar puncture - Table 2:
From the CCQ-DSA images, AUC values calculated for TDCs extracted from ROIs on bilateral CCAs and the AUC ratio between left and right sides
Patient No. AUC-ROI-R (Reference) AUC-ROI-L rAUC 1 1 1.02 1.02 2 1 1.01 1.01 3 1 1.01 1.01 4 1 0.98 0.98 5 1 1.01 1.01 6 1 1.03 1.03 7 1 0.98 0.98 8 1 0.76 0.76 9 1 0.83 0.83 10 1 0.80 0.80 11 1 0.76 0.76 12 1 0.97 0.97 Note:—R indicates right; L, left.
Planes Patient No. 1 2 3 4 5 6 7 8 9 10 11 12 Plane 1 ROI1-R 29 26 27 26 16 18 18 20 23 23 26 20 ROI1-L 28 25 27 24 15 19 18 19 19 22 22 18 rCBV 0.97 0.96 1.00 0.92 0.94 1.06 1.00 0.95 0.83 0.96 0.85 0.90 ROI2-R 22 21 23 19 20 20 17 22 25 16 25 17 ROI2-L 23 20 20 17 20 20 17 15 21 14 28 18 rCBV 1.05 0.95 0.87 0.89 1.00 1.00 1.00 0.68 0.84 0.88 0.72 1.06 Plane 2 ROI1-R 14 25 20 19 10 13 16 22 24 15 23 18 ROI1-L 14 23 22 20 10 12 16 20 20 14 16 19 rCBV 1.00 0.92 1.10 1.05 1.00 0.92 1.00 0.91 0.83 0.93 0.70 1.06 ROI2-R 29 27 33 34 14 28 28 35 30 34 33 31 ROI2-L 27 24 31 30 13 26 29 27 23 26 27 28 rCBV 0.93 0.89 0.94 0.88 0.93 0.93 1.04 0.77 0.77 0.76 0.82 0.90 Plane 3 ROI1-R 17 25 24 25 14 21 20 20 20 24 25 23 ROI1-L 17 23 22 23 14 20 19 16 17 20 20 22 rCBV 1.00 0.92 0.92 0.92 1.00 0.95 0.95 0.80 0.85 0.83 0.80 0.96 rCBV with most asymmetry 0.93 0.89 0.87 0.88 0.93 0.92 0.95 0.68a 0.77a 0.76a 0.70a 0.90 ↵a Significant asymmetric perfusion was detected.
