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Demographic and clinical characteristics of healthy controls and patients with active, remitted, and cured CSa
Healthy Controls Patients with Active CS Patients with Remitted CS Patients with Cured CS F/χ2 P Value Age (yr) 42.3 ± 10.4 41.9 ± 8.7 47.1 ± 10.0 41.4 ± 10.0 5.9 NS Sex (M/F) 6:29 1:7 1:6 4:16 0.3 NS Years of education 13.5 ± 3.4 14.4 ± 3.0 12.9 ± 2.3 13.4 ± 3.1 0.3 NS 24-Hour urinary free cortisol 133 ± 52 543 ± 307 152 ± 74 122 ± 75 26.3 <.001b Smoking status (nonsmoker/smoker/ex-smoker) 12/12/11 7/1/0 2/4/1 9/5/6 10.4 NS Disease duration (mo) NA 77.6 ± 77.4 44.6 ± 21.9 64.6 ± 34.0 0.99 NS Origin (pituitary/adrenal/ectopic/AIMAH) NA 5/3/0/0 3/2/1/1 17/2/0/0 10.8 NS Hypertension (no/yes) 35/0 4/4 3/4 13/7 20.9 <.001c Hypercholesterolemia (no/yes) 31/4 7/1 7/0 17/3 1.2 NS Hypertriglyceridemia (no/yes) 29/6 6/2 3/4 9/11 10.5 .015d Central obesity (no/yes) 25/10 2/6 0/7 9/11 15.6 .001e Body mass indexg (no/overweight/obesity) 22/11/2 2/5/1 1/3/3 8/9/3 12.6 .049f Note:—NS indicates not significant; AIMAH, ACTH-independent macronodular adrenal hyperplasia.
↵a Data are expressed as mean ± SD.
↵b Healthy controls vs active CS (<.001); active CS vs remitted CS (<.001); active CS vs cured CS (<.001).
↵c Healthy controls vs active CS (<.001); healthy controls vs remitted CS (<.001); healthy controls vs cured CS (<.001).
↵d Healthy controls vs remitted CS (.043); healthy controls vs cured CS (.006).
↵e Healthy controls vs active CS (.015); healthy controls vs remitted CS (.001).
↵f Healthy controls vs remitted CS (.015).
↵g Body mass index: normal, ≤25; overweight, 25–30; obesity, >30.
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