Comparison of Fine-Needle Aspiration and Core Needle Biopsy under Ultrasonographic Guidance for Detecting Malignancy and for the Tissue-Specific Diagnosis of Salivary Gland Tumors

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Fig 1.
The results of USFNA and USCNB in all patients.

Table 1:

Demographic data and results of US image analysis^{^a}

	Total (N = 412)	FNA (n = 155)	CNB (n = 257)	P Value
Age (yr)^{^b}	53 ± 16	55 ± 15	52 ± 16	.084
Size (cm)^{^b}	2.2 ± 1.1	2.2 ± 1.2	2.2 ± 1.1	.694
Sex				.374
Male	217	86 (55)	131 (51)
Female	195	69 (45)	126 (49)
Location				.637
Parotid gland	311	119 (77)	192 (75)
Submandibular gland	101	36 (23)	65 (25)
No. of needle passes				.052
1	267	112 (72)	155 (60)
2	132	37 (24)	95 (37)
3	13	6 (4)	7 (3)

↵a Unless otherwise indicated, data show the number of lesions, with percentages in parentheses.
↵b Data show means.

Table 3:

False-positive and false-negative results of USFNA and USCNB in salivary gland tumors

Biopsy Results	Final Pathologies
USFNA
False-negative
Warthin tumor	Mucoepidermoid carcinoma
Pleomorphic adenoma	Mucoepidermoid carcinoma
Pleomorphic adenoma	Mucoepidermoid carcinoma
Pleomorphic adenoma	Carcinoma ex pleomorphic adenoma
Basal cell adenoma	Basal cell adenocarcinoma
False-positive
Squamous cell carcinoma	Warthin tumor with squamous metaplasia
Acinic cell carcinoma	Oncocytoma
Acinic cell carcinoma	Oncocytoma
USCNB
False-negative
Pleomorphic adenoma	Epithelial-myoepithelial carcinoma
Pleomorphic adenoma	Carcinoma ex pleomorphic adenoma
Pleomorphic adenoma	Carcinoma ex pleomorphic adenoma
Basal cell adenoma	Basal cell adenocarcinoma
False-positive
Low-grade mucoepidermoid carcinoma	Pleomorphic adenoma

Table 4:

Comparison of diagnostic accuracies of USFNA and USCNB in salivary gland tumors^{^a}

Diagnostic Accuracy	USFNA	USCNB	P Value
Sensitivity	76 (16/21)	93 (52/56)	.057
Specificity	96 (71/74)	99 (173/174)	.081
Accuracy	92 (87/95)	98 (225/230)	.024^{^b}
Positive predictive value	84 (16/19)	98 (52/53)	.054
Negative predictive value	93 (71/76)	98 (173/177)	.133

Table 5:

Comparison of diagnostic accuracies of USFNA and USCNB in salivary gland tumors according to operator experience level^{^a}

Diagnostic Values	FNA (%)	CNB (%)	P Value
Sensitivity
Faculty	79 (15/19)	89 (32/36)	.426
Trainee	50 (1/2)	100 (20/20)	.091
Specificity
Faculty	97 (57/59)	99 (96/97)	.557
Trainee	93 (14/15)	100 (77/77)	.163
Accuracy
Faculty	92 (72/78)	96 (128/133)	.336
Trainee	88 (15/17)	100 (97/97)	.021^{^b}

Table 6:

Comparison of diagnostic accuracies of USFNA and USCNB according to the internal component of salivary gland tumors^{^a}

Diagnostic Values	FNA (%)	CNB (%)	P Value
Sensitivity
Solid/predominantly solid	82 (14/17)	94 (46/49)	.172
Cystic/predominantly cystic	50 (2/4)	86 (6/7)	.491
Specificity
Solid/predominantly solid	97 (66/68)	99 (154/155)	.221
Cystic/predominantly cystic	83 (5/6)	100 (19/19)	.240
Accuracy
Solid/predominantly solid	94 (80/85)	98 (200/204)	.130
Cystic/predominantly cystic	70 (7/10)	96 (25/26)	.057