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Research ArticlePediatric Neuroimaging

Choroid Plexus Neoplasms: Toward a Distinction between Carcinoma and Papilloma Using Arterial Spin-Labeling

V. Dangouloff-Ros, D. Grevent, M. Pagès, T. Blauwblomme, R. Calmon, C. Elie, S. Puget, C. Sainte-Rose, F. Brunelle, P. Varlet and N. Boddaert
American Journal of Neuroradiology September 2015, 36 (9) 1786-1790; DOI: https://doi.org/10.3174/ajnr.A4332
V. Dangouloff-Ros
aFrom the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.)
eU1000 (V.D.-R., D.G., R.C., F.B., N.B.)
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  • ORCID record for V. Dangouloff-Ros
D. Grevent
aFrom the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.)
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
eU1000 (V.D.-R., D.G., R.C., F.B., N.B.)
gInserm UMR1163 - Institut Imagine (D.G., R.C., F.B., N.B.), Université Paris Descartes-Sarbonne Paris Cité, Paris, France
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M. Pagès
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
hDepartment of Neuropathology (M.P., P.V.), Centre Hospitalier Sainte Anne, Paris, France.
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T. Blauwblomme
bPediatric Neurosurgery (T.B., S.P., C.S.-R.)
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
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R. Calmon
aFrom the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.)
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
eU1000 (V.D.-R., D.G., R.C., F.B., N.B.)
gInserm UMR1163 - Institut Imagine (D.G., R.C., F.B., N.B.), Université Paris Descartes-Sarbonne Paris Cité, Paris, France
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C. Elie
cClinical Research Unit (C.E.), Hôpital Necker–Enfants Malades, Assistance-Publique Hôpitaux de Paris, Paris, France
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S. Puget
bPediatric Neurosurgery (T.B., S.P., C.S.-R.)
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
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C. Sainte-Rose
bPediatric Neurosurgery (T.B., S.P., C.S.-R.)
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
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F. Brunelle
aFrom the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.)
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
eU1000 (V.D.-R., D.G., R.C., F.B., N.B.)
gInserm UMR1163 - Institut Imagine (D.G., R.C., F.B., N.B.), Université Paris Descartes-Sarbonne Paris Cité, Paris, France
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P. Varlet
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
hDepartment of Neuropathology (M.P., P.V.), Centre Hospitalier Sainte Anne, Paris, France.
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N. Boddaert
aFrom the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.)
dUniversity René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France
eU1000 (V.D.-R., D.G., R.C., F.B., N.B.)
fU781 (N.B.), Institut national de la santé et de la recherche médicale, Paris, France
gInserm UMR1163 - Institut Imagine (D.G., R.C., F.B., N.B.), Université Paris Descartes-Sarbonne Paris Cité, Paris, France
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    Fig 1.

    Measurement of ASL and DSC-PWI of a choroid plexus carcinoma (patient 8). Top left: 3D T1-weighted MR imaging. Top right: 3D T1-weighted MR imaging with gadolinium injection. Bottom left: arterial spin-labeling. ROIs are drawn around the whole tumor and in the contralateral gray matter. Bottom right: dynamic susceptibility contrast perfusion-weighted imaging. ROIs are drawn around the whole tumor and in the contralateral white matter.

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    Fig 2.

    Measurement of ASL and DSC-PWI of a choroid plexus papilloma (patient 1). Top left: 3D T1-weighted MR imaging. Top right: 3D T1-weighted MR imaging with gadolinium injection. Bottom left: arterial spin-labeling. ROIs are drawn around the whole tumor and in the contralateral gray matter. Bottom right: dynamic susceptibility contrast perfusion-weighted imaging. ROIs are drawn around the whole tumor and in the contralateral white matter.

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    Fig 3.

    Histopathology. Hematoxylin-eosin staining (top) and CD34 immunostaining (bottom) of 1 representative patient with papilloma (case 3, on the left) and 1 representative patient with carcinoma (case 8, on the right), showing the differences in the microvascular architecture. (Magnification × 250.)

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    Fig 4.

    Number of microvessels per square millimeter for papillomas, atypical papillomas, and carcinomas. The gray point in the papillomas corresponds to patient 4, in whom microvessels are probably overestimated due to crushing artifacts.

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    Fig 5.

    Relative cerebral blood flow of papillomas, atypical papillomas, and carcinomas by using ASL. rCBF is normalized to the contralateral gray matter. Two atypical papillomas had the same value and share the same point (0.4).

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    Fig 6.

    Relative cerebral blood volume of papillomas, atypical papillomas, and carcinomas by using DSC-PWI. rCBV is normalized to the contralateral white matter.

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    Fig 7.

    Bland-Altman plots comparing the 2 observers. Difference versus average of rCBF by using ASL (top) and DSC-PWI (bottom). Solid lines and adjacent numbers indicate the difference between observers and mean values between observers, while dashed lines indicate the limits of agreement.

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American Journal of Neuroradiology: 36 (9)
American Journal of Neuroradiology
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1 Sep 2015
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V. Dangouloff-Ros, D. Grevent, M. Pagès, T. Blauwblomme, R. Calmon, C. Elie, S. Puget, C. Sainte-Rose, F. Brunelle, P. Varlet, N. Boddaert
Choroid Plexus Neoplasms: Toward a Distinction between Carcinoma and Papilloma Using Arterial Spin-Labeling
American Journal of Neuroradiology Sep 2015, 36 (9) 1786-1790; DOI: 10.3174/ajnr.A4332

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Choroid Plexus Neoplasms: Toward a Distinction between Carcinoma and Papilloma Using Arterial Spin-Labeling
V. Dangouloff-Ros, D. Grevent, M. Pagès, T. Blauwblomme, R. Calmon, C. Elie, S. Puget, C. Sainte-Rose, F. Brunelle, P. Varlet, N. Boddaert
American Journal of Neuroradiology Sep 2015, 36 (9) 1786-1790; DOI: 10.3174/ajnr.A4332
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