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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

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Research ArticleAdult Brain
Open Access

Dynamic Susceptibility Contrast-Enhanced MR Perfusion Imaging in Assessing Recurrent Glioblastoma Response to Superselective Intra-Arterial Bevacizumab Therapy

R. Singh, K. Kesavabhotla, S.A. Kishore, Z. Zhou, A.J. Tsiouris, C.G. Filippi, J.A. Boockvar and I. Kovanlikaya
American Journal of Neuroradiology October 2016, 37 (10) 1838-1843; DOI: https://doi.org/10.3174/ajnr.A4823
R. Singh
aFrom the Departments of Neurological Surgery (R.S., Z.Z.)
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K. Kesavabhotla
cDepartment of Neurological Surgery (K.K.), Northwestern University Feinberg School of Medicine, Chicago, Illinois
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S.A. Kishore
bRadiology (S.A.K., A.J.T., I.K.), Weill Cornell Medical College, New York, New York
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Z. Zhou
aFrom the Departments of Neurological Surgery (R.S., Z.Z.)
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A.J. Tsiouris
bRadiology (S.A.K., A.J.T., I.K.), Weill Cornell Medical College, New York, New York
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C.G. Filippi
dDepartments of Radiology (C.G.F.)
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J.A. Boockvar
eNeurological Surgery (J.A.B.), Lenox Hill Hospital, Hofstra–North Shore-LIJ School of Medicine, New York, New York.
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I. Kovanlikaya
bRadiology (S.A.K., A.J.T., I.K.), Weill Cornell Medical College, New York, New York
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    Fig 1.

    ROI selection. A, Precontrast T1-weighted images are used to select the ROI in the normal-appearing white matter on the side contralateral to the lesion (black circle). B, Postcontrast T1-weighted images are compared with the precontrast T1-weighted images to select the ROI representing the area of max contrast enhancement (black circle). C, Region of max rCBV is selected by using rCBV maps (white circle). D, T2-FLAIR images are used to select areas representing the nonenhancing T2 hyperintense signal abnormality surrounding the tumor (black circle).

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    Fig 2.

    MR imaging changes from SIACI BV treatment. Imaging from 2 patients (study patients 8 and 25) demonstrates a decrease in contrast enhancement, T2 signal abnormalities, rCBV, and rCBF following SIACI BV.

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American Journal of Neuroradiology: 37 (10)
American Journal of Neuroradiology
Vol. 37, Issue 10
1 Oct 2016
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R. Singh, K. Kesavabhotla, S.A. Kishore, Z. Zhou, A.J. Tsiouris, C.G. Filippi, J.A. Boockvar, I. Kovanlikaya
Dynamic Susceptibility Contrast-Enhanced MR Perfusion Imaging in Assessing Recurrent Glioblastoma Response to Superselective Intra-Arterial Bevacizumab Therapy
American Journal of Neuroradiology Oct 2016, 37 (10) 1838-1843; DOI: 10.3174/ajnr.A4823

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Dynamic Susceptibility Contrast-Enhanced MR Perfusion Imaging in Assessing Recurrent Glioblastoma Response to Superselective Intra-Arterial Bevacizumab Therapy
R. Singh, K. Kesavabhotla, S.A. Kishore, Z. Zhou, A.J. Tsiouris, C.G. Filippi, J.A. Boockvar, I. Kovanlikaya
American Journal of Neuroradiology Oct 2016, 37 (10) 1838-1843; DOI: 10.3174/ajnr.A4823
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