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Index by author

November 01, 2016; Volume 37,Issue 11

  1. Treiman, G.S.

    1. FELLOWS' JOURNAL CLUBEXTRACRANIAL VASCULAR
      Open Access
      Vitamin D and Vulnerable Carotid Plaque
      J.S. McNally, T.M. Burton, B.W. Aldred, S.-E. Kim, M.S. McLaughlin, L.B. Eisenmenger, G.J. Stoddard, J.J. Majersik, D.V. Miller, G.S. Treiman and D.L. Parker
      American Journal of Neuroradiology November 2016, 37 (11) 2092-2099; DOI: https://doi.org/10.3174/ajnr.A4849

      Angiotensin II stimulates intraplaque hemorrhage in animal models, and the angiotensin system is highly regulated by vitamin D. The authors' purpose was to determine whether low vitamin D levels predict carotid intraplaque hemorrhage (IPH). In this cross-sectional study, 65 patients with carotid disease underwent carotid MR imaging and blood draw. Systemic clinical confounders and local lumen imaging markers were recorded. They performed multivariable Poisson regression by using generalized estimating equations to account for up to 2 carotid arteries per patient and backward elimination of confounders. The authors found that low vitamin D levels (<30 ng/mL) were a significant predictor of MRI-detected IPH, along with plaque thickness. They conclude that vitamin D insufficiency was associated with both the presence and volume of carotid IPH in patients with carotid atherosclerosis and that these results link low vitamin D levels with plaque vulnerability.

  2. Tsarfaty, G.

    1. EDITOR'S CHOICEADULT BRAIN
      Early Biomarkers from Conventional and Delayed-Contrast MRI to Predict the Response to Bevacizumab in Recurrent High-Grade Gliomas
      D. Daniels, D. Guez, D. Last, C. Hoffmann, D. Nass, A. Talianski, G. Tsarfaty, S. Salomon, A.A. Kanner, D.T. Blumenthal, F. Bokstein, S. Harnof, D. Yekutieli, S. Zamir, Z.R. Cohen, L. Zach and Y. Mardor
      American Journal of Neuroradiology November 2016, 37 (11) 2003-2009; DOI: https://doi.org/10.3174/ajnr.A4866

      Twenty-four patients with recurrent high-grade gliomas were scanned before and during bevacizumab treatment with standard and delayed-contrast MRI. The mean change in lesion volumes of responders (overall survival, >1 year) and nonresponders (overall survival, <1 year) was evaluated. Treatment-response-assessment maps (TRAMs) were calculated by subtracting conventional T1WI (acquired a few minutes postcontrast) from delayed T1WI (acquired with a delay of >1 hour postcontrast). These maps depict the spatial distribution of contrast accumulation and clearance. At progression, the increase in lesion volumes in delayed-contrast MR imaging was 37.5% higher than the increase in conventional T1WI. The authors conclude that the benefit of standard and delayed-contrast MRI for assessing and predicting the response to bevacizumab was demonstrated and that the increased sensitivity of delayed-contrast MRI reflects its potential contribution to the management of bevacizumab-treated patients with recurrent HGG.

  3. Tu, R.

    1. Current Procedural Terminology: History, Structure, and Relationship to Valuation for the Neuroradiologist
      T.M. Leslie-Mazwi, J.A. Bello, R. Tu, G.N. Nicola, W.D. Donovan, R.M. Barr and J.A. Hirsch
      American Journal of Neuroradiology November 2016, 37 (11) 1972-1976; DOI: https://doi.org/10.3174/ajnr.A4863

  4. Turk, A.S.

    1. INTERVENTIONAL
      Geographic Differences in Endovascular Treatment and Retreatment of Cerebral Aneurysms
      A.S. Turk, S.C. Johnston, S. Hetts, J. Mocco, J. English, Y. Murayama, C.J. Prestigiacomo, D. Lopes, Y.P. Gobin, K. Carroll and C. McDougall
      American Journal of Neuroradiology November 2016, 37 (11) 2055-2059; DOI: https://doi.org/10.3174/ajnr.A4857
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