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Research ArticleAdult Brain
Open Access

Diffusion-Weighted Imaging for Predicting and Monitoring Primary Central Nervous System Lymphoma Treatment Response

W.-Y. Huang, J.-B. Wen, G. Wu, B. Yin, J.-J. Li and D.-Y. Geng
American Journal of Neuroradiology November 2016, 37 (11) 2010-2018; DOI: https://doi.org/10.3174/ajnr.A4867
W.-Y. Huang
aFrom the Departments of Radiology (W.-Y.H., J.-J.L.)
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J.-B. Wen
cDepartment of Radiology (J.-B.W., B.Y., D.-Y.G.), Huashan Hospital, Fudan University, Shanghai, China.
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G. Wu
bRadiotherapy (G.W.), Hainan General Hospital, Haikou, Hainan, China
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B. Yin
cDepartment of Radiology (J.-B.W., B.Y., D.-Y.G.), Huashan Hospital, Fudan University, Shanghai, China.
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J.-J. Li
aFrom the Departments of Radiology (W.-Y.H., J.-J.L.)
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D.-Y. Geng
cDepartment of Radiology (J.-B.W., B.Y., D.-Y.G.), Huashan Hospital, Fudan University, Shanghai, China.
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References

  1. 1.↵
    1. Nakajima S,
    2. Okada T,
    3. Yamamoto A, et al
    . Differentiation between primary central nervous system lymphoma and glioblastoma: a comparative study of parameters derived from dynamic susceptibility contrast-enhanced perfusion-weighted MRI. Clin Radiol 2015;70:1393–99 doi:10.1016/j.crad.2015.08.004 pmid:26382744
    CrossRefPubMed
  2. 2.↵
    1. Bhagavathi S,
    2. Wilson JD
    . Primary central nervous system lymphoma. Arch Pathol Lab Med 2008;132:1830–34 pmid:18976024
    PubMedWeb of Science
  3. 3.↵
    1. Kansara R,
    2. Shenkier TN,
    3. Connors JM, et al
    . Rituximab with high dose methotrexate in primary central nervous system lymphoma. Am J Hematol 2015;90:1149–54 doi:10.1002/ajh.24204 pmid:26414492
    CrossRefPubMed
  4. 4.↵
    PDQ Adult Treatment Editorial Board. Primary CNS Lymphoma Treatment. Bethesda, Maryland: National Cancer Institute. Updated September 21, 2015. http://www.cancer.gov/types/lymphoma/patient/primary-cns-lymphoma-treatment-pdq. Accessed June 9, 2016. pmid:26389274
  5. 5.↵
    1. Barajas RF Jr.,
    2. Rubenstein JL,
    3. Chang JS, et al
    . Diffusion-weighted MR imaging derived apparent diffusion coefficient is predictive of clinical outcome in primary central nervous system lymphoma. AJNR Am J Neuroradiol 2010;31:60–66 doi:10.3174/ajnr.A1750 pmid:19729544
    Abstract/FREE Full Text
  6. 6.↵
    1. Wieduwilt MJ,
    2. Valles F,
    3. Issa S, et al
    . Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. Clin Cancer Res 2012;18:1146–55 doi:10.1158/1078-0432.CCR-11-0625 pmid:22228634
    Abstract/FREE Full Text
  7. 7.↵
    1. Lee EJ,
    2. Lee SK,
    3. Agid R, et al
    . Preoperative grading of presumptive low-grade astrocytomas on MR imaging: diagnostic value of minimum apparent diffusion coefficient. AJNR Am J Neuroradiol 2008;29:1872–77 doi:10.3174/ajnr.A1254 pmid:18719036
    Abstract/FREE Full Text
  8. 8.↵
    1. Guo AC,
    2. Cummings TJ,
    3. Dash RC, et al
    . Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 2002;224:177–83 doi:10.1148/radiol.2241010637 pmid:12091680
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Lee KC,
    2. Moffat BA,
    3. Schott AF, et al
    . Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy. Clin Cancer Res 2007;13:443–50 doi:10.1158/1078-0432.CCR-06-1888 pmid:17255264
    Abstract/FREE Full Text
  10. 10.↵
    1. Morris PG,
    2. Correa DD,
    3. Yahalom J, et al
    . Rituximab, methotrexate, procarbazine, and vincristine followed by consolidation reduced-dose whole-brain radiotherapy and cytarabine in newly diagnosed primary CNS lymphoma: final results and long-term outcome. J Clin Oncol 2013;31:3971–79 doi:10.1200/JCO.2013.50.4910 pmid:24101038
    Abstract/FREE Full Text
  11. 11.↵
    1. Abrey LE,
    2. Batchelor TT,
    3. Ferreri AJ, et al
    ; International Primary CNS Lymphoma Collaborative Group. Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol 2005;23:5034–43 doi:10.1200/JCO.2005.13.524 pmid:15955902
    Abstract/FREE Full Text
  12. 12.↵
    1. Iwadate Y,
    2. Suganami A,
    3. Ikegami S, et al
    . Non-deep-seated primary CNS lymphoma: therapeutic responses and a molecular signature. J Neurooncol 2014;117:261–68 doi:10.1007/s11060-014-1379-4 pmid:24488444
    CrossRefPubMed
  13. 13.↵
    1. Prasad SR,
    2. Jhaveri KS,
    3. Saini S, et al
    . CT tumor measurement for therapeutic response assessment: comparison of unidimensional, bidimensional, and volumetric techniques initial observations. Radiology 2002;225:416–19 doi:10.1148/radiol.2252011604 pmid:12409574
    CrossRefPubMed
  14. 14.↵
    1. Liua Y,
    2. Baia R,
    3. Suna H, et al
    . Diffusion-weighted imaging in predicting and monitoring the response of uterine cervical cancer to combined chemoradiation. Clin Radiol 2009;64:1067–74 doi:10.1016/j.crad.2009.07.010 pmid:19822239
    CrossRefPubMed
  15. 15.↵
    1. Server A,
    2. Kulle B,
    3. Maehlen J, et al
    . Quantitative apparent diffusion coefficients in the characterization of brain tumors and associated peritumoral edema. Acta Radiol 2009;6:683–89 doi:10.1080/02841850902933123 pmid:19449234
    CrossRefPubMed
  16. 16.↵
    1. Zacharia TT,
    2. Law M,
    3. Naidich TP, et al
    . Central nervous system lymphoma characterization by diffusion-weighted imaging and MR spectroscopy. J Neuroimaging 2008;18:411–17 doi:10.1111/j.1552-6569.2007.00231.x pmid:18494774
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Africa E,
    2. Pauciulo A,
    3. Vadalà R, et al
    . Primary central nervous system lymphoma: role of DWI in the differential diagnosis. Rays 2005;30:221–26 pmid:16512067
    PubMed
  18. 18.↵
    1. Wu X,
    2. Kellokumpu-Lehtinen PL,
    3. Pertovaara H, et al
    . Diffusion-weighted MRI in early chemotherapy response evaluation of patients with diffuse large B-cell lymphoma: a pilot study—comparison with 2-deoxy-2-fluoro-D-glucose-positron emission tomography/computed tomography. NMR Biomed 2011;24:1181–90 doi:10.1002/nbm.1689 pmid:21387451
    CrossRefPubMed
  19. 19.↵
    1. Valles FE,
    2. Perez-Valles CL,
    3. Regalado S, et al
    . Combined diffusion and perfusion MR imaging as biomarkers of prognosis in immunocompetent patients with primary central nervous system lymphoma. AJNR Am J Neuroradiol 2013;34:35–40 doi:10.3174/ajnr.A3165 pmid:22936096
    Abstract/FREE Full Text
  20. 20.↵
    1. Fujimoto H,
    2. Kazama T,
    3. Nagashima T, et al
    . Diffusion-weighted imaging reflects pathological therapeutic response and relapse in breast cancer. Breast Cancer 2014;21:724–31 doi:10.1007/s12282-013-0449-3 pmid:23400545
    CrossRefPubMed
  21. 21.↵
    1. Chenevert TL,
    2. Stegman LD,
    3. Taylor JM, et al
    . Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors. J Natl Cancer Inst 2000;92:2029–36 doi:10.1093/jnci/92.24.2029 pmid:11121466
    Abstract/FREE Full Text
  22. 22.↵
    1. Chenevert TL,
    2. McKeever PE,
    3. Ross BD
    . Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res 1997;3:1457–66 pmid:9815831
    Abstract
  23. 23.↵
    1. Moffat BA,
    2. Chenevert TL,
    3. Lawrence TS, et al
    . Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci U S A 2005;102:5524–29 doi:10.1073/pnas.0501532102 pmid:15805192
    Abstract/FREE Full Text
  24. 24.↵
    1. Moffat BA,
    2. Hall DE,
    3. Stojanovska J, et al
    . Diffusion imaging for evaluation of tumor therapies in preclinical animal models. MAGMA 2004;17:249–59 doi:10.1007/s10334-004-0079-z pmid:15580371
    CrossRefPubMed
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American Journal of Neuroradiology: 37 (11)
American Journal of Neuroradiology
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W.-Y. Huang, J.-B. Wen, G. Wu, B. Yin, J.-J. Li, D.-Y. Geng
Diffusion-Weighted Imaging for Predicting and Monitoring Primary Central Nervous System Lymphoma Treatment Response
American Journal of Neuroradiology Nov 2016, 37 (11) 2010-2018; DOI: 10.3174/ajnr.A4867

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Diffusion-Weighted Imaging for Predicting and Monitoring Primary Central Nervous System Lymphoma Treatment Response
W.-Y. Huang, J.-B. Wen, G. Wu, B. Yin, J.-J. Li, D.-Y. Geng
American Journal of Neuroradiology Nov 2016, 37 (11) 2010-2018; DOI: 10.3174/ajnr.A4867
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