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Research ArticleAdult Brain
Open Access

Computer-Extracted Texture Features to Distinguish Cerebral Radionecrosis from Recurrent Brain Tumors on Multiparametric MRI: A Feasibility Study

P. Tiwari, P. Prasanna, L. Wolansky, M. Pinho, M. Cohen, A.P. Nayate, A. Gupta, G. Singh, K.J. Hatanpaa, A. Sloan, L. Rogers and A. Madabhushi
American Journal of Neuroradiology December 2016, 37 (12) 2231-2236; DOI: https://doi.org/10.3174/ajnr.A4931
P. Tiwari
aFrom the Department of Biomedical Engineering (P.T., P.P., G.S., A.M.), Case Western Reserve University, Cleveland, Ohio
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  • ORCID record for P. Tiwari
P. Prasanna
aFrom the Department of Biomedical Engineering (P.T., P.P., G.S., A.M.), Case Western Reserve University, Cleveland, Ohio
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L. Wolansky
bUniversity Hospitals Case Medical Center (A.P.N., A.G., L.W., M.C., A.S., L.R.), Cleveland, Ohio
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M. Pinho
cUniversity of Texas Southwestern Medical Center (M.P., K.J.H.), Dallas, Texas.
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M. Cohen
bUniversity Hospitals Case Medical Center (A.P.N., A.G., L.W., M.C., A.S., L.R.), Cleveland, Ohio
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A.P. Nayate
bUniversity Hospitals Case Medical Center (A.P.N., A.G., L.W., M.C., A.S., L.R.), Cleveland, Ohio
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A. Gupta
bUniversity Hospitals Case Medical Center (A.P.N., A.G., L.W., M.C., A.S., L.R.), Cleveland, Ohio
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G. Singh
aFrom the Department of Biomedical Engineering (P.T., P.P., G.S., A.M.), Case Western Reserve University, Cleveland, Ohio
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K.J. Hatanpaa
cUniversity of Texas Southwestern Medical Center (M.P., K.J.H.), Dallas, Texas.
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A. Sloan
bUniversity Hospitals Case Medical Center (A.P.N., A.G., L.W., M.C., A.S., L.R.), Cleveland, Ohio
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L. Rogers
bUniversity Hospitals Case Medical Center (A.P.N., A.G., L.W., M.C., A.S., L.R.), Cleveland, Ohio
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A. Madabhushi
aFrom the Department of Biomedical Engineering (P.T., P.P., G.S., A.M.), Case Western Reserve University, Cleveland, Ohio
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    Fig 1.

    A representative 2D FLAIR section for RN (A) and tumor recurrence (E) shown for 2 different primary brain tumor studies. B and F, The original FLAIR images corresponding to RN (A) and tumor recurrence (E). C, D, G, and H, The top 2 texture features corresponding to RN (A) and tumor recurrence (E), respectively. Red represents high feature value, while blue represents a low feature value for a given pixel.

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    Table 1:

    Summary of study population

    CharacteristicPatient Cohort
    TrainingHoldout
    PrimaryMetastaticPrimaryMetastatic
    No. of patients2221114
    Women12722
    Men91592
    Mean age (yr)52.849.556.352
    Age range (yr)(33–75)(37–65)(43–75)(43–58)
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    Table 2:

    Classifier and blinded-reader detection accuracy on the holdout set using FLAIR or FLAIR, Gd-T1WI, and T2WI protocols when availablea

    Detection Accuracy (Primary Cases, n = 11)Detection Accuracy (Metastatic Cases, n = 4)Overall Accuracy (n = 15)
    Expert 1Expert 2Radiomics ClassifierExpert 1Expert 2Radiomics ClassifierExpert 1Expert 2Radiomics Classifier
    36%54%91%50%50%50%47%53%80%
    • ↵a The ground truth was established on the basis of the true histopathologic diagnosis of the cases on the holdout set.

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American Journal of Neuroradiology: 37 (12)
American Journal of Neuroradiology
Vol. 37, Issue 12
1 Dec 2016
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P. Tiwari, P. Prasanna, L. Wolansky, M. Pinho, M. Cohen, A.P. Nayate, A. Gupta, G. Singh, K.J. Hatanpaa, A. Sloan, L. Rogers, A. Madabhushi
Computer-Extracted Texture Features to Distinguish Cerebral Radionecrosis from Recurrent Brain Tumors on Multiparametric MRI: A Feasibility Study
American Journal of Neuroradiology Dec 2016, 37 (12) 2231-2236; DOI: 10.3174/ajnr.A4931

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Computer-Extracted Texture Features to Distinguish Cerebral Radionecrosis from Recurrent Brain Tumors on Multiparametric MRI: A Feasibility Study
P. Tiwari, P. Prasanna, L. Wolansky, M. Pinho, M. Cohen, A.P. Nayate, A. Gupta, G. Singh, K.J. Hatanpaa, A. Sloan, L. Rogers, A. Madabhushi
American Journal of Neuroradiology Dec 2016, 37 (12) 2231-2236; DOI: 10.3174/ajnr.A4931
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