Article Figures & Data
Figures
- Fig 1.
Comparison of the functional connectivity of the right caudate nucleus between patients with vascular parkinsonism and those with Parkinson disease. Contrast is generated as a 2-tailed t test (scale: t = 0.1–5) with a combination of a voxelwise threshold (uncorrected P < .001) and a cluster-extent threshold (family-wise error rate–corrected P < .05), while controlling for age. Increased functional connectivity of the right caudate nucleus to the perigenual anterior cingulate cortex (MNI coordinates: x = 2, y = 44, z = 2) in axial (A), sagittal (B), and coronal (C) planes is observed. Functional connectivity of the right caudate nucleus to the perigenual anterior cingulate cortex positively correlates with normalized caudate nucleus volumes (D).
- Fig 2.
Comparison of the functional connectivity of the right caudate nucleus between patients with vascular parkinsonism and controls. Contrast is generated as a 2-tailed t test (scale: t = 0.1–5) with a combination of a voxelwise threshold (uncorrected P < .001) and a cluster-extent threshold (family-wise error rate–corrected P < .05), while controlling for age. Decreased functional connectivity of the right caudate nucleus to the posterior cingulate cortex (MNI coordinates: x = 2, y = −42, z = 36) in the axial (A), sagittal (B), and coronal (C) planes is observed. Functional connectivity of the right caudate nucleus to the posterior cingulate cortex negatively correlates with the number of errors during the Stroop Task (D).
Tables
Basal ganglia functional connectivity with the cingulate cortex in patients with VP
Seeds Regions Cluster MNI Coordinates Cluster Size (Voxels) Cluster Uncorrected P Value Cluster FWE-Corrected P Value X Y Z Functional connectivity significantly increased in patients with VP Comparison with controls Right caudate Anterior cingulate gyrus 6 22 12 54 <.0001 <.0001 Left caudate Anterior cingulate gyrus −18 10 32 15 .000003 .00004 Comparison with patients with PD Right caudate Anterior cingulate gyrus, right paracingulate gyrus, left paracingulate gyrus 2 44 2 226 .0019 .026 Functional connectivity significantly decreased in patients with VP Comparison with controls Right caudate Posterior cingulate gyrus, precuneus cortex 2 −42 36 658 .000004 .00006 Left caudate Posterior cingulate gyrus, precuneus cortex 2 −60 52 520 .00002 .0002 Note:—FWE indicates family-wise error.
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