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Research ArticlePediatric Neuroimaging

Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study

C. Cesaretti, M. Nanni, T. Ghi, C. Parazzini, G. Conte, E. Contro, G. Grisolia and A. Righini
American Journal of Neuroradiology March 2016, 37 (3) 521-527; DOI: https://doi.org/10.3174/ajnr.A4570
C. Cesaretti
aFrom the Radiology and Neuroradiology Department (C.C., C.P., G.C., A.R.), Children's Hospital V. Buzzi, Milan, Italy
bMedical Genetics Unit (C.C.), Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy
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M. Nanni
cFetal Medicine Unit (M.N., T.G., E.C.), S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
dObstetrics and Gynecology Department (M.N., G.G.), Carlo Poma Hospital, Mantova, Italy
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T. Ghi
cFetal Medicine Unit (M.N., T.G., E.C.), S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
eObstetrics Department (T.G.), Ospedale Maggiore, University of Parma, Parma, Italy
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C. Parazzini
aFrom the Radiology and Neuroradiology Department (C.C., C.P., G.C., A.R.), Children's Hospital V. Buzzi, Milan, Italy
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G. Conte
aFrom the Radiology and Neuroradiology Department (C.C., C.P., G.C., A.R.), Children's Hospital V. Buzzi, Milan, Italy
fDepartment of Health Sciences (G.C.), University of Milan, Milan, Italy.
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E. Contro
cFetal Medicine Unit (M.N., T.G., E.C.), S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
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G. Grisolia
dObstetrics and Gynecology Department (M.N., G.G.), Carlo Poma Hospital, Mantova, Italy
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A. Righini
aFrom the Radiology and Neuroradiology Department (C.C., C.P., G.C., A.R.), Children's Hospital V. Buzzi, Milan, Italy
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    Fig 1.

    A scheme showing 4 sagittal view examples of the corpus callosum putative region, reporting the 4 groups on the basis of forebrain commissures. IA indicates interthalamic adhesion.

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    Fig 2.

    Group 1 fetuses. A–C, Sagittal, coronal, and axial single-shot fast spin-echo 3-mm-thick T2-weighted sections from a 32-week-GA study with no visible AC or HC. White arrows show the fornical crura. D–F, Sagittal T1 and coronal and axial T2-weighted sections from a postnatal study confirm the prenatal findings. White arrows show the fornical crura with no HC connecting them.

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    Fig 3.

    Group 2 fetuses. A–E, Sagittal, coronal, and axial single-shot fast spin-echo 3-mm-thick T2-weighted sections from a 30-week-GA study with a visible AC (black arrows) but no HC. White arrows show the fornical crura. F–I, Sagittal T1 and coronal and axial T2-weighted sections from a postnatal study confirm prenatal findings: the presence of only the AC (black arrows). White arrows show the fornical crura with no HC connecting them.

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    Fig 4.

    Group 3 fetuses. A–C, Sagittal, coronal, and axial single-shot fast spin-echo 3-mm-thick T2-weighted sections from a 27-week-GA study with a visible vestigial HC (yellow arrows). Black arrows show the AC. D–F, Sagittal T1 and coronal and axial T2-weighted sections from the postnatal study confirm the prenatal findings: the presence of the AC (black arrow) and a vestigial HC (yellow arrows), connecting the fornical crura (white arrows).

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    Fig 5.

    Group 4 fetuses. A–C, Sagittal, coronal, and axial single-shot fast spin-echo 3-mm-thick T2-weighted sections from a 25-week-GA study with a visible AC (black arrow) and a putative HS composed of a vestigial HC and an early rudiment of the CC body (red arrows). This putative HS seems to be located slightly more cranially compared with the simple vestigial HC shown in Fig 3. D–F, Sagittal and coronal T2 and axial T1-weighted sections from a postnatal study confirm prenatal findings: the presence of the AC (black arrow) and a putative HS (red arrows). White arrows show the fornical crura; the dotted line in D intersects the mammillary body and the AC, according to the method reported by Kier and Truwit.15 G and H, Fiber-tracking images from the same study show fibers forming the putative HS (red arrows indicate yellow fibers apparently connecting the cerebral hemispheres and also the fornical crura). Arrowheads indicate Probst bundles (blue and violet fibers), and white arrows show the fornical crura (green and red fibers).

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American Journal of Neuroradiology: 37 (3)
American Journal of Neuroradiology
Vol. 37, Issue 3
1 Mar 2016
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C. Cesaretti, M. Nanni, T. Ghi, C. Parazzini, G. Conte, E. Contro, G. Grisolia, A. Righini
Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study
American Journal of Neuroradiology Mar 2016, 37 (3) 521-527; DOI: 10.3174/ajnr.A4570

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Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study
C. Cesaretti, M. Nanni, T. Ghi, C. Parazzini, G. Conte, E. Contro, G. Grisolia, A. Righini
American Journal of Neuroradiology Mar 2016, 37 (3) 521-527; DOI: 10.3174/ajnr.A4570
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