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Research ArticleNeurointervention

Associations between Cerebral Embolism and Carotid Intraplaque Hemorrhage during Protected Carotid Artery Stenting

G.H. Chung, J.Y. Jeong, H.S. Kwak and S.B. Hwang
American Journal of Neuroradiology April 2016, 37 (4) 686-691; DOI: https://doi.org/10.3174/ajnr.A4576
G.H. Chung
aFrom the Radiology and Research Institute, Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeollabuk-do, Republic of Korea.
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  • ORCID record for G.H. Chung
J.Y. Jeong
aFrom the Radiology and Research Institute, Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeollabuk-do, Republic of Korea.
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H.S. Kwak
aFrom the Radiology and Research Institute, Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeollabuk-do, Republic of Korea.
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S.B. Hwang
aFrom the Radiology and Research Institute, Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeollabuk-do, Republic of Korea.
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    Figure.

    A 77-year-old man with a left acute embolic infarction due to severe stenosis of the left proximal internal carotid artery. A, Axial DWI at admission shows multiple areas of diffusion restriction in the left centrum semiovale (arrow). B, MPRAGE image shows isointensity of the left carotid plaque (arrows). This finding indicates a necrotic core without IPH. C, Lateral projection of left carotid angiography shows moderate stenosis in the proximal cervical portion of the left internal carotid artery (arrows). D, Carotid artery angiogram after protected CAS shows complete recanalization without residual stenosis. E, Axial DWI after CAS shows the new embolic lesions in the left frontal lobe (arrows).

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    Table 1:

    Baseline data for patients with MR-positive IPH or without IPH after carotid stenosis

    MR-Positive IPH (n = 43)No IPH (n = 51)P
    Mean age, y74.3 ± 6.572.9 ± 6.8.324
    Men, no. (%)34 (79.1)31 (60.8).074
    Right side, no. (%)15 (34.9)23 (45.1).400
    Symptomatic event, no. (%)22 (51.2)19 (37.3).213
    Mean degree of stenosis, %78.9 ± 12.475.9 ± 12.3.247
    Cerebrovascular history, no. (%)
        Previous stroke8 (18.6)17 (33.3).159
        Previous cardiac disease10 (23.3)8 (9.8).433
    Cerebrovascular risk factors, no. (%)
        Hypertension26 (60.5)32 (62.7).835
        Diabetes mellitus22 (51.2)22 (41.5).535
        Hyperlipidemia9 (20.9)8 (15.7).595
        Current smoking16 (37.2)20 (39.2)1.000
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    Table 2:

    Postprocedural complications in patients with or without MR-positive IPH

    MR-Positive IPH, no. (%) (n = 43)No IPH, no. (%) (n = 51)P
    Hyperperfusion syndrome3 (7.0)8 (15.7).218
    Ipsilateral ischemic lesions9 (20.9)16 (31.4).349
    Minor stroke00
    Major stroke2 (4.7)0.207
    MI or death00
    • Note:—MI indicates myocardial infarction.

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    Table 3:

    Characteristics of symptomatic and asymptomatic groups in patients with carotid stenosis

    Symptomatic (n = 41)Asymptomatic (n = 53)P
    Mean age, y74.5 ± 5.572.8 ± 7.5.214
    Mean degree of stenosis, %79.0 ± 13.976.0 ± 10.9.258
    MR-positive IPH, no. (%)22 (53.7)19 (35.8).213
    Ipsilateral ischemic lesions, no. (%)17 (41.5)8 (15.1).005a
    Hyperperfusion syndrome, no. (%)5 (12.2)6 (11.3)1.000
    Major stroke, no. (%)1 (2.4)1 (1.9).685
    • ↵a Fisher exact test.

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American Journal of Neuroradiology: 37 (4)
American Journal of Neuroradiology
Vol. 37, Issue 4
1 Apr 2016
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G.H. Chung, J.Y. Jeong, H.S. Kwak, S.B. Hwang
Associations between Cerebral Embolism and Carotid Intraplaque Hemorrhage during Protected Carotid Artery Stenting
American Journal of Neuroradiology Apr 2016, 37 (4) 686-691; DOI: 10.3174/ajnr.A4576

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Associations between Cerebral Embolism and Carotid Intraplaque Hemorrhage during Protected Carotid Artery Stenting
G.H. Chung, J.Y. Jeong, H.S. Kwak, S.B. Hwang
American Journal of Neuroradiology Apr 2016, 37 (4) 686-691; DOI: 10.3174/ajnr.A4576
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