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Research ArticleAdult Brain

Quantitative MRI for Rapid and User-Independent Monitoring of Intracranial CSF Volume in Hydrocephalus

J. Virhammar, M. Warntjes, K. Laurell and E.-M. Larsson
American Journal of Neuroradiology May 2016, 37 (5) 797-801; DOI: https://doi.org/10.3174/ajnr.A4627
J. Virhammar
aFrom the Departments of Neuroscience, Neurology (J.V.)
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M. Warntjes
cCenter for Medical Imaging Science and Visualization (M.W.), Linköping University, Linköping, Sweden
dSyntheticMR (M.W.), Linköping, Sweden
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K. Laurell
eDepartment of Pharmacology and Clinical Neuroscience (K.L.), Umeå University, Umeå, Sweden.
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E.-M. Larsson
bSurgical Sciences, Radiology (E.-M.L.), Uppsala University, Uppsala, Sweden
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    Fig 1.

    A, Fully automatic calculation of total intracranial CSF by using SyMRI. The green line is an intracranial mask used to automatically calculate the intracranial volume (the line was originally red but was colored green in external graphics-editing software to increase clarity). B, Manual segmentation of the lateral ventricles by using SyMRI.

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    Fig 2.

    Baseline brain parenchymal fraction for all subjects as a function of age.

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    Fig 3.

    A, The mean difference in manually segmented lateral ventricular volume with respect to the baseline value (solid line) and the mean difference in automatically calculated total CSF volume with respect to the baseline value (dotted line) plotted at the 5 different time points. B, The mean difference of brain parenchymal fraction with respect to the baseline value at the same time points. Time point 1 and 2 are baseline investigations and the lumbar puncture with CSF removal was performed right after time point 2. The error bars indicate 1 SD.

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    Fig 4.

    A, Correlation plot between the difference in ventricular volume and the difference in total CSF volume for all subjects at all time points. The line indicates a slope of 1.67 and intercept of 0.37. B, Correlation plot between the difference in ventricular volume and the difference in brain parenchymal fraction for all subjects at all time points. The line indicates a slope of −0.104 and an intercept of 0.008.

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American Journal of Neuroradiology: 37 (5)
American Journal of Neuroradiology
Vol. 37, Issue 5
1 May 2016
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Cite this article
J. Virhammar, M. Warntjes, K. Laurell, E.-M. Larsson
Quantitative MRI for Rapid and User-Independent Monitoring of Intracranial CSF Volume in Hydrocephalus
American Journal of Neuroradiology May 2016, 37 (5) 797-801; DOI: 10.3174/ajnr.A4627

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Quantitative MRI for Rapid and User-Independent Monitoring of Intracranial CSF Volume in Hydrocephalus
J. Virhammar, M. Warntjes, K. Laurell, E.-M. Larsson
American Journal of Neuroradiology May 2016, 37 (5) 797-801; DOI: 10.3174/ajnr.A4627
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