Article Figures & Data
Figures
- Fig 1.
Flow diagram of the search strategy and study selection.
Tables
- Table 1:
Summary of studies evaluating the endovascular treatment of very small intracranial aneurysms
Study No. of Patients Patient Age Range (yr) Sex (M/F) IA Size (mm) (Mean) Follow-Up (mo) (Mean) No. of Ruptured IAs No. of Unruptured IAs Total No. of IAs Suzuki et al, 200622 21 31–86 5:16 2.6 25 21 0 21 Nguyen et al, 20084 60 24–92 – 2.7 – 60 0 60 Chen et al, 200823 11 26–73 8:3 2.7 5.3 10 1 11 van Rooji et al, 200910 187 11–78 51:136 ≤3 6 149 47 196 Yang et al, 200924 12 23–88 4:8 2.6 13.4 12 0 12 Brinjikji et al, 20107 71 37–86 10:61 2.7 10.6 24 47 71 Pierot et al, 201025 51 – 10:41 ≤3 – 0 51 51 Chae et al, 201026 30 28–81 11:19 ≤3 13.3 5 26 31 Ioannidis et al, 201015 94 27–80 27:67 ≤3 23 85 12 97 Fang et al, 201027 19 38–63 5:14 2.8 14.1 20 0 20 Zang et al, 201028 11 25–55 1:10 ≤3 7.4 10 1 11 Hwang et al, 201129 38 24–70 12:26 2.5 14.8 23 20 43 Hong et al, 201130 51 17–71 22:29 2.4 14 51 0 51 Iskandar and Nepper-Rasmussen, 20113 107 – 34:73 ≤3 9 87 24 111 Lu et al, 201211 46 27–83 22:24 2.5 46.7 29 23 52 Mohammadian et al, 201331 21 19–72 22:18 ≤3 15 21 0 21 Chung et al, 201332 72 – 24:48 2.8 – 72 0 72 Starke et al, 201214 91 – 26:65 2.8 9.5 91 0 91 Li et al, 201433 16 33–62 7:9 1.7 7.7 16 0 16 Dalfino et al, 201418 20 27–80 5:15 2.7 17 17 3 20 Jindal et al, 201534 12 19–70 2:10 2.25 9.25 6 6 12 Yu et al, 201517 35 41–68 23:12 2.6 12–24 35 0 35 Total 1076 844 261 1105 Unruptured Aneurysms, (%) (95% CI) I2 Ruptured Aneurysms, (%) (95% CI) I2 All Aneurysms, (%) (95% CI) I2 Complete angiographic occlusion Initial 85 (77–91) 40 88 (79–93) 71 85 (78–90) 76 Long-term 90 (44–99) 49 86 (80–90) 45 91 (87–94) 45 Periprocedural outcomes Rupture 6 (0–13) 0 9 (6–12) 0 7 (5–9) 0 Thromboembolism 4 (1–8) NA 4 (2–9) 0 4 (3–6) 0 Morbidity 2 (1–12) NA 3 (2–5) 0 2 (2–4) 0 Mortality 2 (1–13) NA 4 (2–7) 0 3 (2–5) 0 Long-term favorable neurologic outcome – – 74 (59–85) NA 79 (64–89) 83 Recanalization – – 9 (5–17) 28 6 (4–11) 54 Retreatment – – 7 (3–14) 12 7 (5–9) 14 Note:—NA indicates not available.
Time Period 1 % (95% CI) Time Period 2 % (95% CI) P Value Initial complete/near complete occlusion 89.0 (82.0–96.0) 85.0 (79.0–91.0) .004 Initial incomplete occlusion 9.0 (2.0–16.0) 15.0 (9.0–21.0) .002 Long-term complete/near complete occlusion 93.0 (90.0–97.0) 94.0 (90.0–97.0) .12 Long-term good neurologic outcome 85.0 (74.0–95.0) 77.0 (53.0–100.0) .12 Procedure-related morbidity 2.0 (0.0–3.0) 2.0 (1.0–3.0) .94 Procedure-related mortality 2.0 (0.0–3.0) 2.0 (0.0–3.0) .81 Procedure-related rupture 7.0 (4.0–10.0) 3.0 (2.0–4.0) .007 Procedure-related thromboembolism 1.0 (0.0–3.0) 3.0 (2.0–5.0) .06 Recanalization 2.0 (0.0–4.0) 5.0 (2.0–9.0) .004 Retreatment 5.0 (3.0–8.0) 4.0 (2.0–5.0) .93
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