T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell–Derived Experimental Glioblastomas

L.S. Politi; G. Brugnara; A. Castellano; M. Cadioli; L. Altabella; M. Peviani; S. Mazzoleni; A. Falini; R. Galli

doi:10.3174/ajnr.A4774

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T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell–Derived Experimental Glioblastomas

L.S. Politi, G. Brugnara, A. Castellano, M. Cadioli, L. Altabella, M. Peviani, S. Mazzoleni, A. Falini and R. Galli

American Journal of Neuroradiology June 2016, 37 (6) E49-E51; DOI: https://doi.org/10.3174/ajnr.A4774

L.S. Politi

aNeuroimaging Research, Hematology/Oncology Division Boston Children's Hospital/Dana Farber Cancer Institute Boston, Massachusetts

bRadiology Department University of Massachusetts Medical School Worcester, Massachusetts

cNeuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy

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G. Brugnara

dNeuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy

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A. Castellano

dNeuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy

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M. Cadioli

dNeuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy

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L. Altabella

dNeuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy

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M. Peviani

eNeuroimaging Research, Hematology/Oncology Division Boston Children's Hospital/Dana Farber Cancer Institute Boston, Massachusetts

fNeuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy

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S. Mazzoleni

gNeural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy IRCCS San Raffaele Scientific Institute Milan, Italy

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A. Falini

hNeuroradiology Unit and CERMAC Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute Milan, Italy

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R. Galli

iNeural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy IRCCS San Raffaele Scientific Institute, Milan, Italy

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1.↵
2. Arevalo-Perez J,
3. Thomas AA,
4. Kaley T, et al
. T1-weighted dynamic contrast-enhanced MRI as a noninvasive biomarker of epidermal growth factor receptor vIII status. AJNR Am J Neuroradiol 2015;36:2256–61 doi:10.3174/ajnr.A4484 pmid:26338913
Abstract/FREE Full Text
2.↵
2. Mazzoleni S,
3. Politi LS,
4. Pala M, et al
. Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis. Cancer Res 2010;70:7500–13 doi:10.1158/0008-5472.CAN-10-2353 pmid:20858720
Abstract/FREE Full Text

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L.S. Politi, G. Brugnara, A. Castellano, M. Cadioli, L. Altabella, M. Peviani, S. Mazzoleni, A. Falini, R. Galli

T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell–Derived Experimental Glioblastomas

American Journal of Neuroradiology Jun 2016, 37 (6) E49-E51; DOI: 10.3174/ajnr.A4774

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T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell–Derived Experimental Glioblastomas

L.S. Politi, G. Brugnara, A. Castellano, M. Cadioli, L. Altabella, M. Peviani, S. Mazzoleni, A. Falini, R. Galli

American Journal of Neuroradiology Jun 2016, 37 (6) E49-E51; DOI: 10.3174/ajnr.A4774

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[1] 1.↵

Arevalo-Perez J,
Thomas AA,
Kaley T, et al
. T1-weighted dynamic contrast-enhanced MRI as a noninvasive biomarker of epidermal growth factor receptor vIII status. AJNR Am J Neuroradiol 2015;36:2256–61 doi:10.3174/ajnr.A4484 pmid:26338913
Abstract/FREE Full Text

[3] Arevalo-Perez J,

[4] Thomas AA,

[5] Kaley T, et al

[6] 2.↵

Mazzoleni S,
Politi LS,
Pala M, et al
. Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis. Cancer Res 2010;70:7500–13 doi:10.1158/0008-5472.CAN-10-2353 pmid:20858720
Abstract/FREE Full Text

[8] Mazzoleni S,

[9] Politi LS,

[10] Pala M, et al

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T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell–Derived Experimental Glioblastomas

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