Index by author

The authors' hypothesis is that incorporating bidirectional contrast agent transport into the DSC MR imaging signal model will improve rCBV estimates in brain tumors. A unidirectional contrast agent extravasation model (Boxerman-Weisskoff) was compared with a bidirectional contrast agent exchange model. For both models, they compared the goodness of fit with the parent leakage-contaminated relaxation rate curves and the difference between modeled interstitial relaxation rate curves and dynamic contrast-enhanced MR imaging in 21 patients with glioblastoma. The authors conclude that the bidirectional model more accurately corrects for the T1 or T2* enhancement arising from contrast agent extravasation due to blood-brain barrier disruption in high-grade gliomas by incorporating interstitial washout rates into the DSC MR imaging relaxation rate model.

The authors explored the effect of multimodal imaging (CT perfusion and/or CT angiography) versus noncontrast CT alone on time to treatment and outcomes in the IMS III trial. Of 656 subjects enrolled in the trial, 90 (13.7%) received CTP and CTA, 216 (32.9%) received CTA (without CTP), and 342 (52.1%) received NCCT alone. Median times from stroke onset to IV tPA in the CTP+CTA, CTA, and NCCT groups were 120.5 vs 117.5 vs 120 minutes, respectively. They conclude that the use of CTA (with or without CTP) did not delay IV tPA or endovascular therapy compared with NCCT in the IMS III trial.