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Research ArticleHEAD & NECK

Performance of CT in the Preoperative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis

C.H. Suh, J.H. Baek, Y.J. Choi and J.H. Lee
American Journal of Neuroradiology January 2017, 38 (1) 154-161; DOI: https://doi.org/10.3174/ajnr.A4967
C.H. Suh
aFrom the Department of Radiology and Research Institute of Radiology (C.H.S., J.H.B., Y.J.C., J.H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
bDepartment of Radiology (C.H.S.), Namwon Medical Center, Namwon-Si, Republic of Korea.
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J.H. Baek
aFrom the Department of Radiology and Research Institute of Radiology (C.H.S., J.H.B., Y.J.C., J.H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
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Y.J. Choi
aFrom the Department of Radiology and Research Institute of Radiology (C.H.S., J.H.B., Y.J.C., J.H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
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J.H. Lee
aFrom the Department of Radiology and Research Institute of Radiology (C.H.S., J.H.B., Y.J.C., J.H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
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    Fig 1.

    Flow diagram of the study selection process.

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    Fig 2.

    Quality Assessment of the Diagnostic Accuracy Studies-2 criteria for the included studies.

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    Fig 3.

    Coupled forest plots of the sensitivity and specificity of CT for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer. Horizontal lines indicate 95% CIs of the individual studies.

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    Fig 4.

    Hierarchic summary receiver operating characteristic curve of the performance of CT for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer.

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    Fig 5.

    The Deeks funnel plot to evaluate publication bias.

Tables

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  • Results of meta-analytic summary estimates of CT and US for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer by level-by-level analysis

    Meta-Analysis Summary Estimate
    Sensitivity (95% CI)P ValueSpecificity (95% CI)P Value
    All cervical lymph nodes
        US51% (42–60)91% (85–95)
        CT62% (52–70).127a87% (80–92).351a
        Combined CT/US69% (61–77).011b81% (74–87).074b
    Lateral cervical lymph nodes
        US71% (57–82)85% (64–95)
        CT70% (59–80).858a89% (81–94).792a
        Combined CT/US90% (80–95).029b70% (43–88).329b
    Central cervical lymph nodes
        US38% (27–52)91% (81–96)
        CT57% (43–69).088a85% (72–92).368a
        Combined CT/US57% (45–68).079b83% (75–89).281b
    • ↵a Comparison for CT vs US.

    • ↵b Comparison for combined CT/US vs US.

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American Journal of Neuroradiology: 38 (1)
American Journal of Neuroradiology
Vol. 38, Issue 1
1 Jan 2017
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Cite this article
C.H. Suh, J.H. Baek, Y.J. Choi, J.H. Lee
Performance of CT in the Preoperative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis
American Journal of Neuroradiology Jan 2017, 38 (1) 154-161; DOI: 10.3174/ajnr.A4967

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Performance of CT in the Preoperative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis
C.H. Suh, J.H. Baek, Y.J. Choi, J.H. Lee
American Journal of Neuroradiology Jan 2017, 38 (1) 154-161; DOI: 10.3174/ajnr.A4967
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  • Diagnostic accuracy of ultrasound, CT and their combination in detecting cervical lymph node metastasis in patients with papillary thyroid cancer: a systematic review and meta-analysis
  • A Scoring System for Prediction of Cervical Lymph Node Metastasis in Patients with Head and Neck Squamous Cell Carcinoma
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  • Meta-analysis of ultrasound for cervical lymph nodes in papillary thyroid cancer: Diagnosis of central and lateral compartment nodal metastases
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    European Journal of Radiology 2019 112
  • Long-Term Follow-Up Results of Ultrasound-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: More Than 5-Year Follow-Up for 84 Tumors
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    Thyroid 2020 30 12
  • US-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: Efficacy and Safety in a Large Population
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    Korean Journal of Radiology 2019 20 12
  • Application of deep learning to the diagnosis of cervical lymph node metastasis from thyroid cancer with CT
    Jeong Hoon Lee, Eun Ju Ha, Ju Han Kim
    European Radiology 2019 29 10
  • Application of deep learning to the diagnosis of cervical lymph node metastasis from thyroid cancer with CT: external validation and clinical utility for resident training
    Jeong Hoon Lee, Eun Ju Ha, DaYoung Kim, Yong Jun Jung, Subin Heo, Yong-ho Jang, Sung Hyun An, Kyungmin Lee
    European Radiology 2020 30 6
  • Contemporary Debates in Adult Papillary Thyroid Cancer Management
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    Endocrine Reviews 2019 40 6
  • Thyroid cancer neck lymph nodes metastasis: Meta-analysis of US and CT diagnosis
    Zhichao Xing, Yuxuan Qiu, Qianru Yang, Yang Yu, Jingyan Liu, Yuan Fei, Anping Su, Jingqiang Zhu
    European Journal of Radiology 2020 129
  • Using ultrasound features and radiomics analysis to predict lymph node metastasis in patients with thyroid cancer
    Fu Li, Denghua Pan, Yun He, Yuquan Wu, Jinbo Peng, Jiehua Li, Ye Wang, Hong Yang, Junqiang Chen
    BMC Surgery 2020 20 1
  • Deep Learning–Based Computer-Aided Diagnosis System for Localization and Diagnosis of Metastatic Lymph Nodes on Ultrasound: A Pilot Study
    Jeong Hoon Lee, Jung Hwan Baek, Ju Han Kim, Woo Hyun Shim, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
    Thyroid 2018 28 10

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