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Research ArticleADULT BRAIN

Body Temperature Modulates Infarction Growth following Endovascular Reperfusion

S. Dehkharghani, M. Bowen, D.C. Haussen, T. Gleason, A. Prater, Q. Cai, J. Kang and R.G. Nogueira
American Journal of Neuroradiology January 2017, 38 (1) 46-51; DOI: https://doi.org/10.3174/ajnr.A4969
S. Dehkharghani
aFrom the Department of Radiology and Imaging Sciences (S.D., M.B., T.G., A.P.), Emory University Hospital, Atlanta, Georgia
bDepartment of Neurology (S.D., D.C.H., R.G.N.), Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Emory University Hospital, Atlanta, Georgia
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M. Bowen
aFrom the Department of Radiology and Imaging Sciences (S.D., M.B., T.G., A.P.), Emory University Hospital, Atlanta, Georgia
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D.C. Haussen
bDepartment of Neurology (S.D., D.C.H., R.G.N.), Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Emory University Hospital, Atlanta, Georgia
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T. Gleason
aFrom the Department of Radiology and Imaging Sciences (S.D., M.B., T.G., A.P.), Emory University Hospital, Atlanta, Georgia
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A. Prater
aFrom the Department of Radiology and Imaging Sciences (S.D., M.B., T.G., A.P.), Emory University Hospital, Atlanta, Georgia
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Q. Cai
cDepartment of Biostatistics (Q.C.), Emory University, Atlanta, Georgia
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J. Kang
dDepartment of Biostatistics (J.K.), University of Michigan, Ann Arbor, Michigan.
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R.G. Nogueira
bDepartment of Neurology (S.D., D.C.H., R.G.N.), Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Emory University Hospital, Atlanta, Georgia
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References

  1. 1.↵
    1. Wolfe KB
    . Effect of hypothermia on cerebral damage resulting from cardiac arrest. Am J Cardiol 1960;6:809–12 doi:10.1016/0002-9149(60)90231-9 pmid:13786308
    CrossRefPubMed
  2. 2.↵
    1. Azzimondi G,
    2. Bassein L,
    3. Nonino F, et al
    . Fever in acute stroke worsens prognosis: a prospective study. Stroke 1995;26:2040–43 doi:10.1161/01.STR.26.11.2040 pmid:7482646
    Abstract/FREE Full Text
  3. 3.↵
    1. Castillo J,
    2. Davalos A,
    3. Marrugat J, et al
    . Timing for fever-related brain damage in acute ischemic stroke. Stroke 1998;29:2455–60 doi:10.1161/01.STR.29.12.2455 pmid:9836750
    Abstract/FREE Full Text
  4. 4.↵
    1. Hajat C,
    2. Hajat S,
    3. Sharma P
    . Effects of poststroke pyrexia on stroke outcome: a meta-analysis of studies in patients. Stroke 2000;31:410–14 doi:10.1161/01.STR.31.2.410 pmid:10657414
    Abstract/FREE Full Text
  5. 5.↵
    1. Kammersgaard LP,
    2. Jorgensen HS,
    3. Rungby JA, et al
    . Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study. Stroke 2002;33:1759–62 doi:10.1161/01.STR.0000019910.90280.F1 pmid:12105348
    Abstract/FREE Full Text
  6. 6.↵
    1. Reith J,
    2. Jorgensen HS,
    3. Pedersen PM, et al
    . Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 1996;347:422–25 doi:10.1016/S0140-6736(96)90008-2 pmid:8618482
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Busto R,
    2. Dietrich WD,
    3. Globus MY, et al
    . Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 1987;7:729–38 pmid:3693428
    Abstract/FREE Full Text
  8. 8.↵
    1. Dehkharghani S,
    2. Bammer R,
    3. Straka M, et al
    . Performance and predictive value of a user-independent platform for CT perfusion analysis: threshold-derived automated systems outperform examiner-driven approaches in outcome prediction of acute ischemic stroke. AJNR Am J Neuroradiol 2015;36:1419–25 doi:10.3174/ajnr.A4363 pmid:25999410
    Abstract/FREE Full Text
  9. 9.↵
    1. Straka M,
    2. Albers G,
    3. Bammer R
    . Real-time diffusion-perfusion mismatch analysis in acute stroke. J Magn Reson Imaging 2010:1024–37 doi:10.1002/jmri.22338 pmid:21031505
    CrossRefPubMed
  10. 10.↵
    1. Axelrod YK,
    2. Diringer MN
    . Temperature management in acute neurologic disorders. Neurol Clin 2008;26:585–603, xi doi:10.1016/j.ncl.2008.02.005 pmid:18514828
    CrossRefPubMed
  11. 11.↵
    1. Dumitrascu OM,
    2. Lamb J,
    3. Lyden PD
    . Still cooling after all these years: meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke. J Cereb Blood Flow Metab 2016;36:1157–64 doi:10.1177/0271678X16645112 pmid:27089911
    Abstract/FREE Full Text
  12. 12.↵
    1. Hong JM,
    2. Lee JS,
    3. Song HJ, et al
    . Therapeutic hypothermia after recanalization in patients with acute ischemic stroke. Stroke 2014;45:134–40 doi:10.1161/STROKEAHA.113.003143 pmid:24203846
    Abstract/FREE Full Text
  13. 13.↵
    1. Lansberg MG,
    2. Cereda CW,
    3. Mlynash M, et al
    ; Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 (DEFUSE 2) Study Investigators. Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue. Neurology 2015;85:708–14 doi:10.1212/WNL.0000000000001853 pmid:26224727
    Abstract/FREE Full Text
  14. 14.↵
    1. Boysen G,
    2. Christensen H
    . Stroke severity determines body temperature in acute stroke. Stroke 2001;32:413–17 doi:10.1161/01.STR.32.2.413 pmid:11157175
    Abstract/FREE Full Text
  15. 15.↵
    1. Kim Y,
    2. Busto R,
    3. Dietrich WD, et al
    . Delayed postischemic hyperthermia in awake rats worsens the histopathological outcome of transient focal cerebral ischemia. Stroke 1996;27:2274–80; discussion 2281 doi:10.1161/01.STR.27.12.2274 pmid:8969793
    Abstract/FREE Full Text
  16. 16.↵
    1. Krieger DW,
    2. De Georgia MA,
    3. Abou-Chebl A, et al
    . Cooling for acute ischemic brain damage (COOL AID): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke 2001;32:1847–54 doi:10.1161/01.STR.32.8.1847 pmid:11486115
    Abstract/FREE Full Text
  17. 17.↵
    1. De Georgia MA,
    2. Krieger DW,
    3. Abou-Chebl A, et al
    . Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 2004;63:312–17 doi:10.1212/01.WNL.0000129840.66938.75 pmid:15277626
    Abstract/FREE Full Text
  18. 18.↵
    1. Aiyagari V,
    2. Diringer MN
    . Fever control and its impact on outcomes: what is the evidence? J Neurol Sci 2007;261:39–46 doi:10.1016/j.jns.2007.04.030 pmid:17537459
    CrossRefPubMed
  19. 19.↵
    1. Karaszewski B,
    2. Carpenter TK,
    3. Thomas RG, et al
    . Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke. J Cereb Blood Flow Metab 2013;33:1083–89 doi:10.1038/jcbfm.2013.52 pmid:23571281
    Abstract/FREE Full Text
  20. 20.↵
    1. Whiteley WN,
    2. Thomas RG,
    3. Lowe G, et al
    . Do acute phase markers explain body temperature and brain temperature after ischemic stroke? Neurology 2012;79:152–58 doi:10.1212/WNL.0b013e31825f04d8 pmid:22744672
    Abstract/FREE Full Text
  21. 21.↵
    1. Cady EB,
    2. D'Souza PC,
    3. Penrice J, et al
    . The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy. Magn Reson Med 1995;33:862–67 doi:10.1002/mrm.1910330620 pmid:7651127
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Dehkharghani S,
    2. Mao H,
    3. Howell L, et al
    . Proton resonance frequency chemical shift thermometry: experimental design and validation toward high-resolution noninvasive temperature monitoring and in vivo experience in a nonhuman primate model of acute ischemic stroke. AJNR Am J Neuroradiol 2015;36:1128–35 doi:10.3174/ajnr.A4241 pmid:25655874
    Abstract/FREE Full Text
  23. 23.↵
    1. Marshall I,
    2. Karaszewski B,
    3. Wardlaw JM, et al
    . Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke. Magn Reson Imaging 2006;24:699–706 doi:10.1016/j.mri.2006.02.002 pmid:16824964
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Lansberg MG,
    2. Straka M,
    3. Kemp S, et al
    ; DEFUSE 2 study investigators. MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012;11:860–67 doi:10.1016/S1474-4422(12)70203-X pmid:22954705
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Campbell BC,
    2. Mitchell PJ,
    3. Yan B, et al
    ; EXTEND-IA investigators. A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA). Int J Stroke 2014;9:126–32 doi:10.1111/ijs.12206 pmid:24207098
    Abstract/FREE Full Text
  26. 26.↵
    1. Saver JL,
    2. Goyal M,
    3. Bonafe A, et al
    ; SWIFT PRIME Investigators. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 2015;372:2285–95 doi:10.1056/NEJMoa1415061 pmid:25882376
    CrossRefPubMed
  27. 27.↵
    1. Christensen H,
    2. Boysen G
    . Acceptable agreement between tympanic and rectal temperatures in acute stroke patients. Int J Clin Pract 2002:56:82–84 pmid:11926710
    PubMed
  28. 28.↵
    1. den Hertog HM,
    2. van der Worp HB,
    3. van Gemert HM, et al
    . An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study. J Neurol 2011;258:302–07 doi:10.1007/s00415-010-5756-4 pmid:20878419
    CrossRefPubMed
  29. 29.↵
    1. Zhu M,
    2. Nehra D,
    3. Ackerman JH, et al
    . On the role of anesthesia on the body/brain temperature differential in rats. J Therm Biol 2004:29:599–603
    PubMed
  30. 30.↵
    1. Ritzl A,
    2. Meisel S,
    3. Wittsack HJ, et al
    . Development of brain infarct volume as assessed by magnetic resonance imaging (MRI): follow-up of diffusion-weighted MRI lesions. J Magn Reson Imaging 2004;20:201–07 doi:10.1002/jmri.20096 pmid:15269944
    CrossRefPubMed
  31. 31.↵
    1. Kim SM,
    2. Kwon SU,
    3. Kim JS, et al
    . Early infarct growth predicts long-term clinical outcome in ischemic stroke. J Neurol Sci 2014;347:205–09 doi:10.1016/j.jns.2014.09.048 pmid:25304056
    CrossRefPubMed
  32. 32.↵
    1. Parry-Jones AR,
    2. Liimatainen T,
    3. Kauppinen RA, et al
    . Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat. Magn Reson Med 2008;59:1239–49 doi:10.1002/mrm.21531 pmid:18421691
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Karaszewski B,
    2. Wardlaw JM,
    3. Marshall I, et al
    . Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke. Brain 2009;132:955–64 pmid:19346327
    Abstract/FREE Full Text
  34. 34.↵
    1. Haussen DC,
    2. Nogueira RG,
    3. Elhammady MS, et al
    . Infarct growth despite full reperfusion in endovascular therapy for acute ischemic stroke. J Neurointerv Surg 2016;8:117–21 doi:10.1136/neurintsurg-2014-011497 pmid:25540178
    Abstract/FREE Full Text
  35. 35.↵
    1. Schlaug G,
    2. Benfield A,
    3. Baird AE, et al
    . The ischemic penumbra operationally defined. Neurology 1999;53
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S. Dehkharghani, M. Bowen, D.C. Haussen, T. Gleason, A. Prater, Q. Cai, J. Kang, R.G. Nogueira
Body Temperature Modulates Infarction Growth following Endovascular Reperfusion
American Journal of Neuroradiology Jan 2017, 38 (1) 46-51; DOI: 10.3174/ajnr.A4969

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Body Temperature Modulates Infarction Growth following Endovascular Reperfusion
S. Dehkharghani, M. Bowen, D.C. Haussen, T. Gleason, A. Prater, Q. Cai, J. Kang, R.G. Nogueira
American Journal of Neuroradiology Jan 2017, 38 (1) 46-51; DOI: 10.3174/ajnr.A4969
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