Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleFunctional
Open Access

Real-Time Motor Cortex Mapping for the Safe Resection of Glioma: An Intraoperative Resting-State fMRI Study

T.-m. Qiu, F.-y. Gong, X. Gong, J.-s. Wu, C.-p. Lin, B.B. Biswal, D.-x. Zhuang, C.-j. Yao, X.-l. Zhang, J.-f. Lu, F.-p. Zhu, Y. Mao and L.-f. Zhou
American Journal of Neuroradiology November 2017, 38 (11) 2146-2152; DOI: https://doi.org/10.3174/ajnr.A5369
T.-m. Qiu
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.-m. Qiu
F.-y. Gong
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F.-y. Gong
X. Gong
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for X. Gong
J.-s. Wu
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.-s. Wu
C.-p. Lin
bCenter for Computational Systems Biology (C.-p.L.), Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C.-p. Lin
B.B. Biswal
cDepartment of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark, New Jersey.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B.B. Biswal
D.-x. Zhuang
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.-x. Zhuang
C.-j. Yao
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C.-j. Yao
X.-l. Zhang
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for X.-l. Zhang
J.-f. Lu
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.-f. Lu
F.-p. Zhu
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F.-p. Zhu
Y. Mao
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Mao
L.-f. Zhou
aFrom the Department of Neurological Surgery (T.-m.Q., F.-y.G., X.G., J.-s.W., D.-x.Z., C.-j.Y., X.-l.Z., J.-f.L., F.-p.Z., Y.M., L.-f.Z.), Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L.-f. Zhou
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Validation of iR-fMRI with DCS. A, The pR-fMRI scan shows the motor cortex located posterior to the tumor. B, DCS locates positive sites in the hand area (H) and positive sites in the mouth area (M). The green and blue dots in A represent the positive sites in the hand and mouth areas, respectively, located by intraoperative DCS. C, iR-fMRI reveals that the motor cortex is behind the tumor cavity. D, Intact motor cortex after tumor resection. The green and blue dots represent the positive sites in the hand and mouth areas, respectively, located by intraoperative DCS. Pre-op indicates preoperative; Post-op, postoperative; L, left; R, right.

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Procedure for iR-fMRI- and DCS-assisted tumor resection. A, pR-fMRI scan reveals that the motor cortex is located behind the left frontal lesion. B, Direct cortical stimulation locates 2 positive sites in the hand area (H), 1 positive site in the foot area (L), and 2 positive sites in the language area (1 and 2). C, The iR-fMRI scan displays the motor cortex behind the tumor cavity at a distance from the tumor residue (green arrow). D, Intraoperative MR image suggests a small amount of tumor residue closer to the deep motor area behind the tumor cavity (green arrow). E, The final iR-fMRI scan shows that the motor cortex located behind the tumor cavity is well-protected. F, The final MR imaging scan reveals complete tumor resection. L indicates left; R, right.

Tables

  • Figures
  • Comparison of the results from iR-fMRI and DCS for 14 of the 30 patients

    No.Intraoperative R-fMRI
    TPTNFPFN
    29700
    53830
    812210
    121813
    1801901
    1921903
    204803
    2111420
    224310
    252403
    2631021
    2731201
    292804
    302604
    • Note:—TP indicates true-positive; TN, true-negative; FP, false-positive; FN, false-negative.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 38 (11)
American Journal of Neuroradiology
Vol. 38, Issue 11
1 Nov 2017
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Real-Time Motor Cortex Mapping for the Safe Resection of Glioma: An Intraoperative Resting-State fMRI Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
T.-m. Qiu, F.-y. Gong, X. Gong, J.-s. Wu, C.-p. Lin, B.B. Biswal, D.-x. Zhuang, C.-j. Yao, X.-l. Zhang, J.-f. Lu, F.-p. Zhu, Y. Mao, L.-f. Zhou
Real-Time Motor Cortex Mapping for the Safe Resection of Glioma: An Intraoperative Resting-State fMRI Study
American Journal of Neuroradiology Nov 2017, 38 (11) 2146-2152; DOI: 10.3174/ajnr.A5369

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Real-Time Motor Cortex Mapping for the Safe Resection of Glioma: An Intraoperative Resting-State fMRI Study
T.-m. Qiu, F.-y. Gong, X. Gong, J.-s. Wu, C.-p. Lin, B.B. Biswal, D.-x. Zhuang, C.-j. Yao, X.-l. Zhang, J.-f. Lu, F.-p. Zhu, Y. Mao, L.-f. Zhou
American Journal of Neuroradiology Nov 2017, 38 (11) 2146-2152; DOI: 10.3174/ajnr.A5369
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Resting State fMRI for Motor Cortex Mapping in Children with Epilepsy
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire