Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleHead and Neck Imaging
Open Access

Apparent Diffusion Coefficient Histograms of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Squamous Cell Carcinoma: Assessment of Tumor Heterogeneity and Comparison with Histopathology

T. de Perrot, V. Lenoir, M. Domingo Ayllón, N. Dulguerov, M. Pusztaszeri and M. Becker
American Journal of Neuroradiology November 2017, 38 (11) 2153-2160; DOI: https://doi.org/10.3174/ajnr.A5370
T. de Perrot
aFrom the Division of Radiology, Department of Imaging and Medical Informatics (T.d.P., V.L., M.D.A., M.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T. de Perrot
V. Lenoir
aFrom the Division of Radiology, Department of Imaging and Medical Informatics (T.d.P., V.L., M.D.A., M.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V. Lenoir
M. Domingo Ayllón
aFrom the Division of Radiology, Department of Imaging and Medical Informatics (T.d.P., V.L., M.D.A., M.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Domingo Ayllón
N. Dulguerov
bDivision of Head and Neck Surgery, Department of Clinical Neurosciences (N.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Dulguerov
M. Pusztaszeri
cDivision of Clinical Pathology, Department of Genetic and Laboratory Medicine (M.P.), Geneva University Hospitals, Geneva, Switzerland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Pusztaszeri
M. Becker
aFrom the Division of Radiology, Department of Imaging and Medical Informatics (T.d.P., V.L., M.D.A., M.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Becker
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Rampias T,
    2. Sasaki C,
    3. Psyrri A
    . Molecular mechanisms of HPV induced carcinogenesis in head and neck. Oral Oncol 2014;50:356–63 doi:10.1016/j.oraloncology.2013.07.011 pmid:23953776
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Bishop JA,
    2. Lewis JS Jr.,
    3. Rocco JW, et al
    . HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice. Semin Diagn Pathol 2015;32:344–51 doi:10.1053/j.semdp.2015.02.013 pmid:25724476
    CrossRefPubMed
  3. 3.↵
    1. Amin MB,
    2. Edge S,
    3. Greene F, et al
    . AJCC Cancer Staging Manual, 8th ed. New York: Springer-Verlag; 2017
  4. 4.↵
    1. Salazar CR,
    2. Smith RV,
    3. Garg MK, et al
    . Human papillomavirus-associated head and neck squamous cell carcinoma survival: a comparison by tumor site and initial treatment. Head Neck Pathol 2014;8:77–87 doi:10.1007/s12105-013-0486-4 pmid:24002971
    CrossRefPubMed
  5. 5.↵
    1. Hansson BG,
    2. Rosenquist K,
    3. Antonsson A, et al
    . Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol 2005;125:1337–44 doi:10.1080/00016480510043945 pmid:16303684
    CrossRefPubMed
  6. 6.↵
    1. Duray A,
    2. Descamps G,
    3. Decaestecker C, et al
    . Human papillomavirus DNA strongly correlates with a poorer prognosis in oral cavity carcinoma. Laryngoscope 2012;122:1558–65 doi:10.1002/lary.23298 pmid:22532307
    CrossRefPubMed
  7. 7.↵
    1. Goldenberg D,
    2. Begum S,
    3. Westra WH, et al
    . Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck 2008;30:898–903 doi:10.1002/hed.20796 pmid:18383529
    CrossRefPubMed
  8. 8.↵
    1. Byrd JK,
    2. Wilhoit CS,
    3. Fordham MT, et al
    . Predicting HPV status in head and neck cancer: the predictive value of sociodemographic and disease characteristics. Arch Otolaryngol Head Neck Surg 2012;138:1155–59 doi:10.1001/jamaoto.2013.850 pmid:23247234
    CrossRefPubMed
  9. 9.↵
    1. Varoquaux A,
    2. Rager O,
    3. Dulguerov P, et al
    . Diffusion-weighted and PET/MR imaging after radiation therapy for malignant head and neck tumors. Radiographics 2015;35:1502–27 doi:10.1148/rg.2015140029 pmid:26252192
    CrossRefPubMed
  10. 10.↵
    1. Varoquaux A,
    2. Rager O,
    3. Lovblad KO, et al
    . Functional imaging of head and neck squamous cell carcinoma with diffusion-weighted MRI and FDG PET/CT: quantitative analysis of ADC and SUV. Eur J Nucl Med Mol Imaging 2013;40:842–52 doi:10.1007/s00259-013-2351-9 pmid:23436068
    CrossRefPubMed
  11. 11.↵
    1. Thoeny HC,
    2. De Keyzer F,
    3. King AD
    . Diffusion-weighted MR imaging in the head and neck. Radiology 2012;263:19–32 doi:10.1148/radiol.11101821 pmid:22438440
    CrossRefPubMed
  12. 12.↵
    1. Nakahira M,
    2. Saito N,
    3. Yamaguchi H, et al
    . Use of quantitative diffusion-weighted magnetic resonance imaging to predict human papilloma virus status in patients with oropharyngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol 2014;271:1219–25 doi:10.1007/s00405-013-2641-7 pmid:23880924
    CrossRefPubMed
  13. 13.↵
    1. Kim S,
    2. Loevner L,
    3. Quon H, et al
    . Diffusion-weighted magnetic resonance imaging for predicting and detecting early response to chemoradiation therapy of squamous cell carcinomas of the head and neck. Clin Cancer Res 2009;15:986–94 doi:10.1158/1078-0432.CCR-08-1287 pmid:19188170
    Abstract/FREE Full Text
  14. 14.↵
    1. Schouten CS,
    2. de Graaf P,
    3. Bloemena E, et al
    . Quantitative diffusion-weighted MRI parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma. AJNR Am J Neuroradiol 2015;36:763–67 doi:10.3174/ajnr.A4271 pmid:25721078
    Abstract/FREE Full Text
  15. 15.↵
    1. Just N
    . Improving tumour heterogeneity MRI assessment with histograms. Br J Cancer 2014;111:2205–13 doi:10.1038/bjc.2014.512 pmid:25268373
    CrossRefPubMed
  16. 16.↵
    1. King AD,
    2. Chow KK,
    3. Yu KH, et al
    . Head and neck squamous cell carcinoma: diagnostic performance of diffusion-weighted MR imaging for the prediction of treatment response. Radiology 2013;266:531–38 doi:10.1148/radiol.12120167 pmid:23151830
    CrossRefPubMed
  17. 17.↵
    1. Srinivasan A,
    2. Chenevert TL,
    3. Dwamena BA, et al
    . Utility of pretreatment mean apparent diffusion coefficient and apparent diffusion coefficient histograms in prediction of outcome to chemoradiation in head and neck squamous cell carcinoma. J Comput Assist Tomogr 2012;36:131–37 doi:10.1097/RCT.0b013e3182405435 pmid:22261783
    CrossRefPubMed
  18. 18.↵
    1. Westra WH
    . The pathology of HPV-related head and neck cancer: implications for the diagnostic pathologist. Semin Diagn Pathol 2015;32:42–53 doi:10.1053/j.semdp.2015.02.023 pmid:25804343
    CrossRefPubMed
  19. 19.↵
    1. Chernock RD
    . Morphologic features of conventional squamous cell carcinoma of the oropharynx: ‘keratinizing’ and ‘nonkeratinizing’ histologic types as the basis for a consistent classification system. Head Neck Pathol 2012;6 Suppl 1:S41–47 doi:10.1007/s12105-012-0373-4 pmid:22782222
    CrossRefPubMed
  20. 20.↵
    R Core Team. R: A Language and Environment for Statistical Computing. The R Foundation for Statistical Computing. 2017. Available at: https://www.r-project.org/. Accessed January 24, 2017.
  21. 21.↵
    1. Thomas J,
    2. Primeaux T
    . Is p16 immunohistochemistry a more cost-effective method for identification of human papilloma virus-associated head and neck squamous cell carcinoma? Ann Diagn Pathol 2012;16:91–99 doi:10.1016/j.anndiagpath.2011.09.002 pmid:22197546
    CrossRefPubMed
  22. 22.↵
    1. Driessen JP,
    2. van Bemmel AJ,
    3. van Kempen PM, et al
    . Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion-weighted MRI in head and neck squamous cell carcinomas. Head Neck 2016;38 Suppl 1:E613–18 doi:10.1002/hed.24051 pmid:25783872
    CrossRefPubMed
  23. 23.↵
    1. Le Bihan D,
    2. Breton E,
    3. Lallemand D, et al
    . Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 1988;168:497–505 doi:10.1148/radiology.168.2.3393671 pmid:3393671
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Kim H,
    2. Choi SH,
    3. Kim JH, et al
    . Gliomas: application of cumulative histogram analysis of normalized cerebral blood volume on 3 T MRI to tumor grading. PloS One 2013;8:e63462 doi:10.1371/journal.pone.0063462 pmid:23704910
    CrossRefPubMed
  25. 25.↵
    1. Ahn SJ,
    2. Choi SH,
    3. Kim YJ, et al
    . Histogram analysis of apparent diffusion coefficient map of standard and high B-value diffusion MR imaging in head and neck squamous cell carcinoma: a correlation study with histological grade. Acad Radiol 2012;19:1233–40 doi:10.1016/j.acra.2012.04.019 pmid:22818788
    CrossRefPubMed
  26. 26.↵
    1. Shukla-Dave A,
    2. Lee NY,
    3. Jansen JF, et al
    . Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases. Int J Radiat Oncol Biol Phys 2012;82:1837–44 doi:10.1016/j.ijrobp.2011.03.006 pmid:21601373
    CrossRefPubMed
  27. 27.↵
    1. Porz N,
    2. Bauer S,
    3. Pica A, et al
    . Multi-modal glioblastoma segmentation: man versus machine. PloS One 2014;9:e96873 doi:10.1371/journal.pone.0096873 pmid:24804720
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 38 (11)
American Journal of Neuroradiology
Vol. 38, Issue 11
1 Nov 2017
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Apparent Diffusion Coefficient Histograms of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Squamous Cell Carcinoma: Assessment of Tumor Heterogeneity and Comparison with Histopathology
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
T. de Perrot, V. Lenoir, M. Domingo Ayllón, N. Dulguerov, M. Pusztaszeri, M. Becker
Apparent Diffusion Coefficient Histograms of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Squamous Cell Carcinoma: Assessment of Tumor Heterogeneity and Comparison with Histopathology
American Journal of Neuroradiology Nov 2017, 38 (11) 2153-2160; DOI: 10.3174/ajnr.A5370

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Apparent Diffusion Coefficient Histograms of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Squamous Cell Carcinoma: Assessment of Tumor Heterogeneity and Comparison with Histopathology
T. de Perrot, V. Lenoir, M. Domingo Ayllón, N. Dulguerov, M. Pusztaszeri, M. Becker
American Journal of Neuroradiology Nov 2017, 38 (11) 2153-2160; DOI: 10.3174/ajnr.A5370
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Diffusion-Weighted Imaging to Assess HPV-Positive versus HPV-Negative Oropharyngeal Squamous Cell Carcinoma: The Importance of b-Values
  • Pretreatment DWI with Histogram Analysis of the ADC in Predicting the Outcome of Advanced Oropharyngeal Cancer with Known Human Papillomavirus Status Treated with Chemoradiation
  • MRI with DWI for the Detection of Posttreatment Head and Neck Squamous Cell Carcinoma: Why Morphologic MRI Criteria Matter
  • CT Texture Analysis: Defining and Integrating New Biomarkers for Advanced Oncologic Imaging in Precision Medicine: A Comment on "CT Texture Analysis Potentially Predicts Local Failure in Head and Neck Squamous Cell Carcinoma Treated with Chemoradiotherapy"
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Hydrops Herniation into the Semicircular Canals
  • ASL Sensitivity for Head and Neck Paraganglioma
  • Post SRS Peritumoral Hyperintense Signal of VSs
Show more HEAD AND NECK IMAGING

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire