Article Figures & Data
Figures
- Fig 1.
Tract-based spatial statistics analysis of the correlation between gestational age at birth and DTI parameters (FA, MD, AD, and RD) in term infants. Background images are FA maps; major white matter tracts are green; voxels in the tract with significant positive correlations (P < .05, corrected) are red; voxels with significant negative correlations (P < .05, corrected) are blue. Widespread positive correlations between FA and gestational age at birth and negative correlations between MD, AD, and RD and gestational age at birth were observed.
- Fig 2.
Scatterplots for correlation analyses between gestational age at birth and DTI parameters in white matter ROIs of term infants and children. Data for term infants are in red, and data for 8-year-old children are in blue. Least-square fit lines are also shown. Units for DTI parameters are: FA (no unit); MD, AD, and RD (μm2/ms). Positive correlations (P < .05) between gestational age and FA were observed in many ROIs (marked with an asterisk) for the term infants, but not in any ROI for the 8-year-old children. Likewise, negative correlations (P < .05) between gestational age and MD, AD, and RD were observed for most ROIs (marked with an asterisk) for the term infants, but none were observed for any ROI for the 8-year-old children. (Details of correlation statistics are provided in Table 3.)
Tables
- Table 1:
Demographic information for the healthy term infants and 8-year-old term-born children
Demographics Infants Children No. of patients 44 63 Gestational age at birth, wks (mean ± SD [min, max]) 39.3 ± 1.0 [37.3, 40.7] 39.4 ± 1.2 [37.0, 42.1] Age at MRI (mean ± SD [min, max])a 14.3 ± 1.6 [11, 19] 7.90 ± 0.25 [7.52, 8.51] Gender (M, F) 23, 21 28, 35 RIAS IQ (mean ± SD [min, max]) N/A 110.8 ± 12.5 [82, 147] Note:—IQ indicates intelligence quotient; max, maximum; min, minimum; RIAS, Reynolds Intellectual Assessment Scales.
↵a Unit for infant ages is weeks; for children, years.
- Table 2:
Percentage of imaging voxels in major white matter tracts that showed significant correlation (P < .05, corrected) between DTI parameters (FA, MD, AD, and RD) and gestational age at birth
Infantsa Childrena FA 80, all positive 0 MD 91, all negative 0 AD 87, all negative 0 RD 91, all negative 0 ↵a Information presented as percentage of voxels, correlation type.
- Table 3:
Correlation coefficients (r values) and correlation statistics (P values) between gestational age at birth and DTI parameters in white matter ROIs for the term infants and children
FA Correlation MD Correlation AD Correlation RD Correlation r Value P Value r Value P Value r Value P Value r Value P Value Infants GN 0.28 .07 −0.24 .13 −0.06 .72 −0.29 .06 SP −0.02 .90 0.06 .73 −0.05 .78 0.06 .69 BCC −0.06 .70 −0.15 .34 −0.25 .10 −0.08 .60 PLIC 0.29 .06 −0.67 <.001a −0.54 <.001a −0.59 <.001a ALIC 0.18 .25 −0.72 <.001a −0.59 <.001a −0.61 <.001a EC 0.45 .003a −0.71 <.001a −0.65 <.001a −0.69 <.001a CG 0.32 .04a −0.63 <.001a −0.51 <.001a −0.62 <.001a SCR 0.48 .001a −0.63 <.001a −0.54 <.001a −0.63 <.001a SLF 0.59 <.001a −0.65 <.001a −0.63 <.001a −0.66 <.001a AWM 0.60 <.001a −0.69 <.001a −0.66 <.001a −0.67 <.001a PWM 0.23 .13 −0.59 <.001a −0.61 <.001a −0.52 <.001a OR 0.28 .07 −0.52 <.011a −0.49 .001a −0.47 .001a IFO 0.66 <.001a −0.72 <.001a −0.70 <.001a −0.70 <.001a ILF 0.24 .13 −0.71 <.001a −0.69 <.001a −0.68 <.001a Children GN −0.25 .05 0.16 .21 −0.15 .25 0.22 .08 SP −0.05 .68 0.04 .78 −0.03 .79 0.04 .78 BCC −0.13 .33 0.03 .81 0.00 .99 0.06 .63 PLIC −0.03 .81 −0.02 .88 −0.04 .73 0.01 .93 ALIC 0.08 .54 −0.05 .68 0.09 .51 −0.10 .46 EC −0.05 .69 −0.00 .95 −0.07 .61 0.01 .93 CG −0.08 .53 −0.19 .14 −0.02 .10 −0.16 .21 SCR −0.17 .18 −0.02 .91 −0.24 .06 0.04 .77 SLF 0.01 .95 −0.01 .94 −0.02 .84 −0.02 .89 AWM −0.01 .91 −0.10 .44 −0.06 .64 −0.09 .49 PWM −0.19 .14 −0.00 .97 −0.18 .17 0.08 .52 OR −0.04 .76 −0.05 .72 −0.00 .99 −0.04 .77 IFO −0.21 .10 −0.04 .77 −0.22 .09 0.05 .71 ILF −0.21 .10 0.00 .98 −0.24 .06 0.10 .43 Note:—ALIC indicates anterior limb of internal capsule; AWM, anterior white matter; BCC, body of corpus callosum; CG, cingulum; EC, external capsule; GN, genu of corpus callosum; IFO, inferior frontal occipital fasciculus; ILF, inferior longitudinal fasciculus; OR, optic radiation; PLIC, posterior limb of internal capsule; PWM, posterior white matter; SCR, superior corona radiata; SLF, superior longitudinal fasciculus; SP, splenium of corpus callosum.
↵a Indicates P values for significant correlations.
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