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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Diffusion-Weighted Imaging–Detected Ischemic Lesions following Endovascular Treatment of Cerebral Aneurysms: A Systematic Review and Meta-Analysis

K.M. Bond, W. Brinjikji, M.H. Murad, D.F. Kallmes, H.J. Cloft and G. Lanzino
American Journal of Neuroradiology February 2017, 38 (2) 304-309; DOI: https://doi.org/10.3174/ajnr.A4989
K.M. Bond
aFrom the Mayo Medical School (K.M.B.)
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W. Brinjikji
bDepartment of Radiology (W.B., D.F.K., H.J.C.)
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M.H. Murad
cCenter for Science of Healthcare Delivery (M.H.M.)
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D.F. Kallmes
bDepartment of Radiology (W.B., D.F.K., H.J.C.)
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H.J. Cloft
bDepartment of Radiology (W.B., D.F.K., H.J.C.)
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G. Lanzino
dDepartment of Neurologic Surgery (G.L.), Mayo Clinic, Rochester, Minnesota.
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    Fig 1.

    Flow chart illustrating study selection.

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    Fig 2.

    Forest plot demonstrating the overall rate of silent infarcts following endovascular aneurysm treatment.

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    Fig 3.

    Forest plot demonstrating the overall rate of silent infarcts following treatment with coiling and flow diversion.

Tables

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    Table 1:

    Summary of studies included in meta-analysis

    StudyDesignNo. of PatientsMean AgeSexAneurysmsCirculationTreatmentTime until Imaging (hr)Risk of Bias
    MFRupturedUnrupturedTotalAnteriorPosterior
    Altay et al, 201112R18458.844154a6513319814751C, SAC, BAC<72M
    Biondi et al, 200025R205051511920164C2–4 and 24–48M
    Brasiliense et al, 201616P59591148700706010FD24M
    Cronqvist et al, 200532P4049.41327163046388C18–52M
    Hahnemann et al, 20147R7552.62154075753540SAC<120H
    Heller et al, 201317P765611656810785325SAC24–48H
    Iosif et al, 201518P3853731––49481FD<48H
    Ishibashi et al, 200615R74–––2945746311C, BAC<48H
    Kang et al, 20136R343–99283a038238232359C, SAC, BAC–M
    Kang et al, 201324P4054.8132704040337C, SAC<24M
    Kim et al, 201311R90582072a092927814C<24M
    Kim et al, 201410R58–233506262––C, SAC23–46M
    Kim et al, 201627R309–84225033833830632C, SAC24–48M
    McGuinness et al, 201533P315642782533303FD48–240H
    Nagahata et al, 201134R1458.611301414140C, BAC<96M
    Nishikawa et al, 20134R15458.837117015715710849C, SAC, BAC48–120M
    Park et al, 20165R27157.268203027127122645C, SAC, BAC24L
    Rordorf et al, 20019P1457.241001414140C, BAC<48M
    Sim and Shin, 20128P3957.71128261339327C, SAC, BAC<48M
    Soeda et al, 200313R266081802626026C, BAC48–120M
    Takigawa et al, 201414R11962.9308901191199524SAC, BAC24M
    Tan et al, 201519R74601262074745816FD<24M
    • Note:—R indicates retrospective; P, prospective; C, coiling only; SAC, stent-assisted coiling; BAC, balloon-assisted coiling; FD, flow diversion; H, high; M, moderate; L, low; –, data was not available.

    • ↵a Authors reported sex distribution by number of aneurysms.

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    Table 2:

    Incidence of ischemic strokes as measured by restricted diffusion with DWI

    % DWI+ (95% CI)I2P Value
    Overall49 (42–56)90–
    Location
        Anterior35 (25–47)76.83
        Posterior31 (9–59)87
    Treatment type
        Coiling alone45 (33–56)86Ref
        Balloon-assisted coiling44 (29–60)54.99
        Stent-assisted coiling43 (24–63)93.89
        Flow diversion67 (46–85)87.07
    Sex
        Male32 (17–48)58.47
        Female41 (28–54)84
    Rupture status
        Ruptured42 (17–69)90.87
        Unruptured44 (35–53)87
    Size
        Small52 (39–65)62.55
        Large61 (34–86)38
    • Note:—Ref indicates reference.

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American Journal of Neuroradiology: 38 (2)
American Journal of Neuroradiology
Vol. 38, Issue 2
1 Feb 2017
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K.M. Bond, W. Brinjikji, M.H. Murad, D.F. Kallmes, H.J. Cloft, G. Lanzino
Diffusion-Weighted Imaging–Detected Ischemic Lesions following Endovascular Treatment of Cerebral Aneurysms: A Systematic Review and Meta-Analysis
American Journal of Neuroradiology Feb 2017, 38 (2) 304-309; DOI: 10.3174/ajnr.A4989

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Diffusion-Weighted Imaging–Detected Ischemic Lesions following Endovascular Treatment of Cerebral Aneurysms: A Systematic Review and Meta-Analysis
K.M. Bond, W. Brinjikji, M.H. Murad, D.F. Kallmes, H.J. Cloft, G. Lanzino
American Journal of Neuroradiology Feb 2017, 38 (2) 304-309; DOI: 10.3174/ajnr.A4989
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  • Suspected Metallic Embolization Distal to Coiled Intracranial Aneurysms Detectable by Susceptibility-Weighted MR Imaging
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