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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research Article

Transverse Sinus Stenosis Is the Most Sensitive MR Imaging Correlate of Idiopathic Intracranial Hypertension

P.P. Morris, D.F. Black, J. Port and N. Campeau
American Journal of Neuroradiology March 2017, 38 (3) 471-477; DOI: https://doi.org/10.3174/ajnr.A5055
P.P. Morris
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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D.F. Black
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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J. Port
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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N. Campeau
aFrom the Department of Radiology, Mayo Clinic, Rochester, Minnesota.
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    Fig 1.

    A–C, Transverse sinus stenosis on coronal T1 postgadolinium MR imaging. A and B, Images from a 43-year-old female patient with idiopathic intracranial hypertension. CSF opening pressure was 380 mm H2O. Postgadolinium coronal 3D fast-spoiled gradient recalled images, section thickness = 2.4 mm, demonstrate stenosis of the transverse sinuses bilaterally (arrows). The expected Δ configuration is distorted and collapsed bilaterally (A). This is more easily appreciated on images from within the same study by comparing with the images of the same sinuses more posteriorly (B). C and D, Images from a 36-year-old female patient with IIH. CSF opening pressure was 370 mm H2O. Postgadolinium T1-weighted image (C) with coronal reformatting from a 3D acquisition, with a section thickness = 2 mm, TR = 650 ms, TE = 12 ms; and oblique projectional image from a gadolinium-bolused MRV sequence, with TR = 3.83 ms and TE = 1.39 ms. Stenoses of the transverse sinuses are evident on both images (arrows). E and F, Coronal T1-weighted image from a 32-year-old female patient with IIH. CSF opening pressure was 304 mm H2O. Virtually complete collapse of the transverse sinuses can be discerned bilaterally (arrows). A sagittal raw data image (F) from the gadolinium-bolused MRV, section thickness = 0.66 mm, suggests an appearance of herniation of the temporo-occipital tissues into the transverse sinus space. G, By contrast, an image from a control patient, a 49-year-old woman with multiple medical problems but no specific explanation for her symptoms of headache. A coronal postgadolinium T1-weighted image, section thickness = 4 mm, shows the expected Δ configuration (arrows) of the preserved transverse sinuses bilaterally.

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    Fig 2.

    Schema for scoring transverse sinus patency based on Farb et al (2003).13 Transverse sinuses were rated by using the MRV, MIP, and raw data images on a 5-point scale bilaterally between 0 (absent) and 4 (full expected contour of a normally sized transverse sinus). The scoring system does not discern etiologies of the narrowing, merely the degree of patency/stenosis on each side. A maximum possible score of 8 would, therefore, indicate full patency on each side. R indicates right; L, left.

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    Fig 3.

    Patency scores on MRV interpretation. A summation of left and right patency scores, maximal normal = 8, was performed on the blinded readings of the MRV images independent of clinical data or the MR imaging appearance. The scatter of scores shows a clear discernment between patients with IIH and controls. Almost all controls scored ≥5, while patients with IIH almost all scored ≤5.

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    Table 1:

    Clinical characteristics of patients with idiopathic intracranial hypertension and controls

    IIH (n = 63)Controls (n = 96)P Value
    Age (mean) (yr)31.6 ± 10.635.5 ± 9.8
    Female/male58:572:24
    BMI36.5 ± 8.227.5 ± 6.4<.0001
    Duration of symptoms (mean) (yr)4.9 ± 6.8
    CSF opening pressure (mm H2O) (mean)356.9 ± 89
    • Note:—BMI indicates body mass index.

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    Table 2:

    Results—MRI findings, interpreted independently of MRV findings

    Retrospective Study InterpretationIIH (n = 63)Controls (n = 96)
    Empty sella34 (53%)5 (5%)
    Dilated optic nerve sheath of >6 mm40 (63%)4 (4%)
    DWI bright spot at fundus6 (9%)1 (1%)
    Papilledema20 (34%)4 (4%)
    Bilateral TS stenosis on coronal T2 post gadolinium53 (83%)7 (7%)
    Internal cephalocele into the transverse sinus32 (50%)0
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    Table 3:

    Results—MRV cross-sectional area measurements on transverse sinuses

    Left TS Proximal (Mean) (mm2)Left TS DistalRight TS ProximalRight TS DistalLeft + Right ProximalLeft + Right Distal
    Controls24.7 ± 14.123.9 ± 10.737.5 ± 15.929.9 ± 11.462.2 ± 19.353.8 ± 15.4
    IIH19.2 ± 13.32.9 ± 2.128.4 ± 14.24.1 ± 4.147.5 ± 2.47.1 ± 4.8
    P value (1-way ANOVA)NS.0001.0003.0001.0001.0001
    • Note:—NS indicates not significant.

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American Journal of Neuroradiology: 38 (3)
American Journal of Neuroradiology
Vol. 38, Issue 3
1 Mar 2017
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P.P. Morris, D.F. Black, J. Port, N. Campeau
Transverse Sinus Stenosis Is the Most Sensitive MR Imaging Correlate of Idiopathic Intracranial Hypertension
American Journal of Neuroradiology Mar 2017, 38 (3) 471-477; DOI: 10.3174/ajnr.A5055

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Transverse Sinus Stenosis Is the Most Sensitive MR Imaging Correlate of Idiopathic Intracranial Hypertension
P.P. Morris, D.F. Black, J. Port, N. Campeau
American Journal of Neuroradiology Mar 2017, 38 (3) 471-477; DOI: 10.3174/ajnr.A5055
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