Article Figures & Data
Figures
- Fig 1.
Probabilistic independent component analysis of presurgical DSC-MR imaging of a patient undergoing EDAS. Probability maps of arterial (left) and venous (right) components are shown on an axial section. The respective time courses show a delayed response in the venous component. The color bar indicates local probability. Note the high probability for the venous component in the left hemispheric cortex, which is the symptomatic side.
- Fig 2.
Temporal changes in the mean local probability of the tissue to belong to either the arterial (red), venous (blue), or capillary (green) component. The dominance of the venous component at baseline in the symptomatic hemisphere indicates delayed perfusion. Note the normalization in dominance with time, suggesting an accelerated perfusion of the surgical region.
- Fig 3.
Comparison between the results from probabilistic ICA and the postoperative DSA studies in 2 sample patients. The results for the arterial and venous component are shown on the left, with the arterial component in red and the venous component in blue. The sagittal view of the respective postoperative DSA study is depicted directly to the right side of these graphs. Upper part: Note that this patient did not exhibit the pattern of an inversion of the probabilities as presented in Fig 2 for the whole sample. The respective postoperative DSA study does not show any new anastomoses between the donor artery and the intracranial vasculature. Lower part: This patient exhibited an inversion of the probabilities on the surgical side with a postoperative decrease of the venous component. The newly formed anastomoses with the intracranial arteries are indicated with a red arrow.
Tables
- Table 1:
Study participants—characteristics, history of TIA, and stroke and imaging data at the time of the first and last scan relative to the operation and the number of observations
ID Age (yr) Sex Diagnosis Events Pre- and Postoperation Imaging Data Pre- Post- Time Range (days) Time Points 1 55 F ICAS TIA −19–373 5 2 65 F ICAS Stroke TIA −14–364 4 3 75 F ICAS Stroke 107–365 4 4 66 F ICAS TIA + Stroke 99–372 4 5 63 M ICAS Stroke −14–370 4 6 55 F MMD Stroke −71–172 3 7 23 F MMD Stroke −4–94 2 8 67 M ICAS TIA −7–190 2 9 56 F MMD TIA −7–135 2 10 47 F ICAS Stroke −3–186 3 11 70 F ICAS TIA + Stroke −15 1 12 35 F MMD TIA + Stroke 116 1 13 35 F MMD TIA 437 1 Note:—ID indicates identification.
- Table 2:
Significance of the association between the time after the operation and the measurements of interest within the surgical side, the contralateral side, and their interaction
P Interaction r Surgical Side P Surgical Side r Control Side P Control Side Artery .258 0.024 .418 −0.109 .194 Vein .001a −0.426 .002a 0.051 .281 Capillary .009 −0.332 .020 −0.003 .489 rCBF .270 −0.017 .444 −0.116 .226 rCBV .404 0.157 .121 0.113 .192 TTP .120 0.181 .151 0.260 .039 Note:—P indicates probability; r, correlation coefficient.
↵a Significant results after correction for multiple comparisons using a Bonferroni correction.
