Article Figures & Data
Figures
- Fig 1.
Image-processing workflow. The coregistration of different sequences allows the extraction of multimodal parameters from an ROI.
- Fig 2.
Box-and-whisker plots of volumes, FA, and MD of the right and left SCPs in patients and controls.
Tables
- Table 1:
Demographic, clinical, and neuroimaging features in patients with PSP-P, PSP-RS, PD, and healthy controls
PSP-P (n = 9) PSP-RS (n = 21) PD (n = 20) HC (n = 30) Age (mean) (yr) 70.1 ± 4.8 71.9 ± 5.9 66.2 ± 3.0 67.2 ± 7.2 Sex, % male 100% 57% 50% 47% Disease duration (mean) (yr) 6.3 ± 3.7 3.1 ± 1.4 7.5 ± 3.7 – MMSE (mean) 22.1 ± 3.6 19.0 ± 5.4 23.2 ± 3.3 – UPDRS-III (mean) 22.8 ± 17.7 39.3 ± 7.7 27.1 ± 9.1 – HY (mean) 2.9 ± 0.7 3.4 ± 0.8 2.2 ± 0.5 – SCP right Volume (No. of voxels) (mean) 5652 ± 1172 5282 ± 753 6907 ± 1306 6569 ± 944 FA (mean) 0.44 ± 0.05 0.40 ± 0.05 0.48 ± 0.04 0.45 ± 0.02 MD (×10−3 mm2/s) (mean) 0.873 ± 0.06 0.949 ± 0.170 0.851 ± 0.089 0.833 ± 0.031 SCP left Volume (No. of voxels) (mean) 5315 ± 1121 4812 ± 701 6369 ± 1205 5961 ± 894 FA (mean) 0.44 ± 0.04 0.39 ± 0.05 0.47 ± 0.04 0.45 ± 0.02 MD (×10−3 mm2/s (mean) 0.895 ± 0.061 0.974 ± 0.074 0.874 ± 0.066 0.857 ± 0.023 Note:—HC indicates healthy controls; MMSE, Mini-Mental State Examination; UPDRS-III, Unified Parkinson's Disease Rating Scale–Motor Examination; HY, Hohen and Yahr score.
- Table 2:
P values from the statistical tests among different groups after correction for multiple comparisons (Tukey test)a
PD vs HC PSP-P vs HC PSP-RS vs HC PSP-P vs PD PSP-RS vs PD PSP-P vs PSP-RS Age 1 1 .02b 0.1 .01b 1 Sex .1 .0001b .1 .008b 1 .01b Disease duration – – – 1 .0001b .02b MMSE – – – 1 .01b 1 UPDRS-III – – – 1 .0022b .002b HY – – – .0004b .94 .001b SCP right Volume .66 .008b .00005b .001b .000004b .95 FA .01b .66 .0005b .004b 1.45 × 10−8b .16 MD .89 .38 .0003b .77 .01b .31 SCP left Volume .44 .03b .00008b .002b .000002b .81 FA .15 .58 .0000005b .03b 9.33 × 10−10b .007b MD .70 .16 9.30 × 10−10b .67 .000001b .003b Note:— HC indicates healthy controls; MMSE, Mini-Mental State Examination; UPDRS-III, Unified Parkinson's Disease Rating Scale-Motor Examination; HY, Hohen and Yahr score.
↵a Sex differences were assessed with χ2 tests. Age differences were assessed with ANOVA. Disease duration differences were assessed using ANCOVA, with age and sex as covariates. Other clinical and imaging differences were assessed with ANCOVA, with age, sex, and disease duration, as covariates. Correction for multiple comparisons was performed with the Tukey honest significant difference test.
↵b Significant.
