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Research ArticleNeurointervention

Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries

R. Doddasomayajula, B. Chung, F. Hamzei-Sichani, C.M. Putman and J.R. Cebral
American Journal of Neuroradiology March 2017, 38 (3) 570-576; DOI: https://doi.org/10.3174/ajnr.A5088
R. Doddasomayajula
aFrom the Bioengineering Department (R.D., B.C., J.R.C.), Volgenau School of Engineering, George Mason University, Fairfax, Virginia
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  • ORCID record for R. Doddasomayajula
B. Chung
aFrom the Bioengineering Department (R.D., B.C., J.R.C.), Volgenau School of Engineering, George Mason University, Fairfax, Virginia
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F. Hamzei-Sichani
bDepartment of Neurosurgery (F.H.-S.), Icahn School of Medicine at Mount Sinai, New York, New York
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C.M. Putman
cInterventional Neuroradiology (C.M.P.), Inova Fairfax Hospital, Falls Church, Virginia.
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J.R. Cebral
aFrom the Bioengineering Department (R.D., B.C., J.R.C.), Volgenau School of Engineering, George Mason University, Fairfax, Virginia
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    Fig 1.

    Ruptured-versus-unruptured aneurysms. Ratio of mean hemodynamic (A) and geometric (B) variables of ruptured over unruptured aneurysms for all aneurysms (red bars) and by location (green bars, BAtip; blue bars, ICAbif). Asterisks indicate statistically significant differences. Hemo indicates hemodynamic; geom indicates geometric; <taper>, mean taper; KE, kinetic energy; SR, shear rate; VO, vorticity; VD, viscous dissipation; <WSS>, mean WSS; podent, POD entropy; podenum, POD number of modes; <OSI>, mean OSI; A, aneurysm; N, neck; AR, aspect ratio.

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    Fig 2.

    BAtip-versus-ICAbif aneurysms. Ratio of mean hemodynamic (A) and geometric (B) variables of BAtip aneurysms over ICAbif aneurysms. Asterisks indicate statistically significant differences. KE indicates kinetic energy; SR, shear rate; VO, vorticity; VD, viscous dissipation; <WSS>, mean WSS; podent, POD entropy; podenum, POD number of modes; <OSI>, mean OSI; hemo, hemodynamic; geom, geometric; <taper>, mean taper; A, aneurysm; N, neck; AR, aspect ratio.

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    Fig 3.

    Comparison of hemodynamic variables across BAtip and ICAbif aneurysms grouped according to their sizes as small, medium, and large. KE indicates kinetic energy; SR, shear rate; VO, vorticitiy; VD, viscous dissipation; <WSS>, mean WSS; podent, POD entropy; podenum, POD number of modes; hemo, hemodynamic.

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    Fig 4.

    Examples of a ruptured (upper row) and an unruptured (lower row) BAtip aneurysm. Peak systole flow visualizations show the following: wall shear stress distribution (A and E), inflow jet (B and F), flow pattern (C and G), and vortex core lines (D and H). White lines indicate the aneurysm necks.

  • Fig 5.
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    Fig 5.

    Examples of a ruptured (upper row) and an unruptured (lower row) ICAbif aneurysm. Peak systole flow visualizations show the following: wall shear stress distribution (A and E), inflow jet (B and F), flow pattern (C and G), and vortex core lines (D and H). White lines indicate the aneurysm necks.

Tables

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  • Hemodynamic and geometric variables used in the study and the aspect of the aneurysm they characterize

    VariablesMetricsCharacterizes
    Hemodynamics
        Q, ICIInflow rate, inflow concentration indexInflow jet
        VE, KEMean velocity, kinetic energyFlow speed in aneurysm
        VO, SR, VDVorticity, shear rate, viscous dissipationFlow rotation deformation/dissipation in aneurysm
        <WSS>, WSSmin, WSSmax, SCI, LSAMean, min, and max WSS, shear concentration index, area under low WSSWSS distribution
        <OSI>, OSImaxMean, max oscillatory shear indexOscillatory flow/WSS
        CorelenLength of vortex core linesFlow complexity
        Podent, podenumPOD entropy and number of modesFlow stability
    Geometry
        Aneurysym size, volume, area, SizeRAneurysm diameter, volume, area, size ratioAneurysm size
        Neck size, areaNeck diameter, areaNeck size
        Depth, aspect ratioAneurysm depth, aspect ratioAneurysm shape elongation
        Artery, branch1, branch2Diameter parent and branch arteriesArtery sizes
        SymmetryRatio of branch diametersBifurcation symmetry
        <Taper>, taper1, taper2Mean taper, branch taperArtery tapering
    • Note:—POD indicates proper orthogonal decomposition; SizeR, size ratio.

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American Journal of Neuroradiology: 38 (3)
American Journal of Neuroradiology
Vol. 38, Issue 3
1 Mar 2017
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R. Doddasomayajula, B. Chung, F. Hamzei-Sichani, C.M. Putman, J.R. Cebral
Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries
American Journal of Neuroradiology Mar 2017, 38 (3) 570-576; DOI: 10.3174/ajnr.A5088

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Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries
R. Doddasomayajula, B. Chung, F. Hamzei-Sichani, C.M. Putman, J.R. Cebral
American Journal of Neuroradiology Mar 2017, 38 (3) 570-576; DOI: 10.3174/ajnr.A5088
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