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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Liquid Embolic Agents for Endovascular Embolization: Evaluation of an Established (Onyx) and a Novel (PHIL) Embolic Agent in an In Vitro AVM Model

D.F. Vollherbst, C.M. Sommer, C. Ulfert, J. Pfaff, M. Bendszus and M.A. Möhlenbruch
American Journal of Neuroradiology July 2017, 38 (7) 1377-1382; DOI: https://doi.org/10.3174/ajnr.A5203
D.F. Vollherbst
aFrom the Department of Neuroradiology (D.F.V., C.U., J.P., M.B., M.A.M.)
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C.M. Sommer
bClinic for Diagnostic and Interventional Radiology (C.M.S.), University Hospital Heidelberg, Heidelberg, Germany
cClinic for Diagnostic and Interventional Radiology (C.M.S.), Klinikum Stuttgart, Stuttgart, Germany.
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C. Ulfert
aFrom the Department of Neuroradiology (D.F.V., C.U., J.P., M.B., M.A.M.)
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J. Pfaff
aFrom the Department of Neuroradiology (D.F.V., C.U., J.P., M.B., M.A.M.)
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M. Bendszus
aFrom the Department of Neuroradiology (D.F.V., C.U., J.P., M.B., M.A.M.)
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M.A. Möhlenbruch
aFrom the Department of Neuroradiology (D.F.V., C.U., J.P., M.B., M.A.M.)
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References

  1. 1.↵
    1. Friedlander RM
    . Clinical practice. Arteriovenous malformations of the brain. N Engl J Med 2007;356:2704–12 doi:10.1056/NEJMcp067192 pmid:17596605
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Pierot L,
    2. Cognard C,
    3. Herbreteau D, et al
    . Endovascular treatment of brain arteriovenous malformations using a liquid embolic agent: results of a prospective, multicentre study (BRAVO). Eur Radiol 2013;23:2838–45 doi:10.1007/s00330-013-2870-6 pmid:23652849
    CrossRefPubMed
  3. 3.↵
    1. van Rooij WJ,
    2. Sluzewski M,
    3. Beute GN
    . Brain AVM embolization with Onyx. AJNR Am J Neuroradiol 2007;28:172–77; discussion 178 pmid:17213451
    Abstract/FREE Full Text
  4. 4.↵
    1. Gross BA,
    2. Du R
    . Diagnosis and treatment of vascular malformations of the brain. Curr Treat Options Neurol 2014;16:279 doi:10.1007/s11940-013-0279-9 pmid:24318447
    CrossRefPubMed
  5. 5.↵
    1. Taki W,
    2. Yonekawa Y,
    3. Iwata H, et al
    . A new liquid material for embolization of arteriovenous malformations. AJNR Am J Neuroradiol 1990;11:163–68 pmid:2105599
    Abstract/FREE Full Text
  6. 6.↵
    1. Bruno CA Jr.,
    2. Meyers PM
    . Endovascular management of arteriovenous malformations of the brain. Interv Neurol 2013;1:109–23 doi:10.1159/000346927 pmid:25187772
    CrossRefPubMed
  7. 7.↵
    1. Hu YC,
    2. Newman CB,
    3. Dashti SR, et al
    . Cranial dural arteriovenous fistula: transarterial Onyx embolization experience and technical nuances. J Neurointerv Surg 2011;3:5–13 doi:10.1136/jnis.2010.003707 pmid:21990779
    Abstract/FREE Full Text
  8. 8.↵
    1. Elsenousi A,
    2. Aletich VA,
    3. Alaraj A
    . Neurological outcomes and cure rates of embolization of brain arteriovenous malformations with n-butyl cyanoacrylate or Onyx: a meta-analysis. J Neurointerv Surg 2016;8:265–72 doi:10.1136/neurintsurg-2014-011427 pmid:25540177
    Abstract/FREE Full Text
  9. 9.↵
    1. Ayad M,
    2. Eskioglu E,
    3. Mericle RA
    . Onyx: a unique neuroembolic agent. Expert Rev Med Devices 2006;3:705–15 doi:10.1586/17434440.3.6.705 pmid:17280535
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Kocer N,
    2. Hanımoğlu H,
    3. Batur Ş, et al
    . Preliminary experience with precipitating hydrophobic injectable liquid in brain arteriovenous malformations. Diagn Interv Radiol 2016;22:184–89 doi:10.5152/dir.2015.15283 pmid:26782157
    CrossRefPubMed
  11. 11.↵
    1. Samaniego EA,
    2. Kalousek V,
    3. Abdo G, et al
    . Preliminary experience with Precipitating Hydrophobic Injectable Liquid (PHIL) in treating cerebral AVMs. J Neurointerv Surg 2016 Jan 27. [Epub ahead of print] doi:10.1136/neurintsurg-2015-012210 pmid:26819446
    CrossRefPubMed
  12. 12.↵
    1. Leyon JJ,
    2. Chavda S,
    3. Thomas A, et al
    . Preliminary experience with the liquid embolic material agent PHIL (precipitating hydrophobic injectable liquid) in treating cranial and spinal dural arteriovenous fistulas: technical note. J Neurointerv Surg 2016;8:596–602 doi:10.1136/neurintsurg-2015-011684 pmid:25994938
    Abstract/FREE Full Text
  13. 13.↵
    1. Ishikawa M,
    2. Horikawa M,
    3. Yamagami T, et al
    . Embolization of arteriovenous malformations: effect of flow control and composition of n-butyl-2 cyanoacrylate and iodized oil mixtures with and without ethanol in an in vitro model. Radiology 2016;279:910–16 doi:10.1148/radiol.2015142583 pmid:26690906
    CrossRefPubMed
  14. 14.↵
    1. Inagawa S,
    2. Isoda H,
    3. Kougo H, et al
    . In-vitro simulation of NBCA embolization for arteriovenous malformation. Interv Neuroradiol 2003;9:351–58 doi:10.1177/159101990300900404 pmid:20591314
    CrossRefPubMed
  15. 15.↵
    1. Chang W,
    2. Loecher MW,
    3. Wu Y, et al
    . Hemodynamic changes in patients with arteriovenous malformations assessed using high-resolution 3D radial phase-contrast MR angiography. AJNR Am J Neuroradiol 2012;33:1565–72 doi:10.3174/ajnr.A3010 pmid:22499844
    Abstract/FREE Full Text
  16. 16.↵
    1. Nornes H,
    2. Grip A
    . Hemodynamic aspects of cerebral arteriovenous malformations. J Neurosurg 1980;53:456–64 doi:10.3171/jns.1980.53.4.0456 pmid:7420165
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Rossitti S
    . Pathophysiology of increased cerebrospinal fluid pressure associated to brain arteriovenous malformations: the hydraulic hypothesis. Surg Neurol Int 2013;4:42 doi:10.4103/2152-7806.109657 pmid:23607064
    CrossRefPubMed
  18. 18.↵
    1. Frontera JA,
    2. Moatti J,
    3. de los Reyes KM, et al
    . Safety and cost of stent-assisted coiling of unruptured intracranial aneurysms compared with coiling or clipping. J Neurointerv Surg 2014;6:65–71 doi:10.1136/neurintsurg-2012-010544 pmid:23223396
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 38 (7)
American Journal of Neuroradiology
Vol. 38, Issue 7
1 Jul 2017
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Cite this article
D.F. Vollherbst, C.M. Sommer, C. Ulfert, J. Pfaff, M. Bendszus, M.A. Möhlenbruch
Liquid Embolic Agents for Endovascular Embolization: Evaluation of an Established (Onyx) and a Novel (PHIL) Embolic Agent in an In Vitro AVM Model
American Journal of Neuroradiology Jul 2017, 38 (7) 1377-1382; DOI: 10.3174/ajnr.A5203

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Liquid Embolic Agents for Endovascular Embolization: Evaluation of an Established (Onyx) and a Novel (PHIL) Embolic Agent in an In Vitro AVM Model
D.F. Vollherbst, C.M. Sommer, C. Ulfert, J. Pfaff, M. Bendszus, M.A. Möhlenbruch
American Journal of Neuroradiology Jul 2017, 38 (7) 1377-1382; DOI: 10.3174/ajnr.A5203
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  • Brain Arteriovenous Malformation In Vitro Model for Transvenous Embolization Using 3D Printing and Real Patient Data
  • Experimental investigation of transvenous embolization of arteriovenous malformations using different in vivo models
  • Experimental investigation of transvenous embolization of arteriovenous malformations using different in vivo models
  • Imaging Artifacts of Liquid Embolic Agents on Conventional CT in an Experimental in Vitro Model
  • Intermixed Dimethyl-Sulfoxide-Based Nonadhesive Liquid Embolic Agents Delivered Serially via the Same Microcatheter for Cerebral AVM Treatment
  • Extra-small dual-lumen micro-balloon catheters can improve endovascular embolization: an experimental in vivo and in vitro study
  • Assessment of human placenta as an ex-vivo vascular model for testing of liquid embolic agent injections with adjunctive techniques
  • Investigation of a New Version of the Liquid Embolic Agent PHIL with Extra-Low-Viscosity in an Endovascular Embolization Model
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