Article Figures & Data
Figures
- Fig 1.
A and B, Two examples of metastatic lymph nodes (white arrows) classified as cystic.
- Fig 2.
A and B, Two examples of metastatic lymph nodes (white arrows) classified as solid.
- Fig 3.
An example of radiographic extracapsular spread associated with a solid metastatic level II nodal mass (black asterisk) in a patient with right base of tongue oropharyngeal squamous cell carcinoma (black arrow).
- Fig 4.
Data flow chart of patient selection.
- Fig 5.
Kaplan-Meier survival curves. Overall disease-free survival was significantly lower among patients with cystic-versus-solid metastatic regional lymph nodes at staging (P = .013; hazard ratio = 2.21; 95% confidence interval, 1.18–4.14).
Tables
Characteristic All Patients (n = 183) (No.) (%) Solid Node Group (n = 78) (No.) (%) Cystic Node Group (n = 105) (No.) (%) Mean age (yr) 56.1 56.2 56.1 Male sex 168 (91.8) 75 (96.2) 93 (88.6) Smoking status Never smoked (<1 Py) 56 (30.6) 23 (29.4) 33 (31.4) Ever smoked 120 (65.6) 51 (65.3) 69 (65.7) <10 Py 14 (7.7) 4 (5.1) 10 (9.5) >10 Py 68 (37.1) 30 (38.5) 38 (36.2) Unknown Py 38 (20.7) 17 (21.8) 21 (20.0) Unknown 1 (0.5) 0 (0.0) 1 (0.95) Other tobacco 6 (3.3) 4(5.1) 2 (1.9) T classification T1 74 (40.4) 28 (35.9) 46 (43.8) T2 73 (39.9) 35 (44.9) 38 (36.2) T3 16 (8.7) 7(8.9) 9 (8.6) T4 17 (9.3) 7 (9.0) 10 (9.5) Unknown 3 (1.6) 1 (1.3) 2 (1.9) N classification N1 31 (16.9) 13 (16.7) 18 (17.1) N2a 24 (13.1) 11 (14.1) 13 (12.4) N2b 97 (53.0) 37 (47.4) 60 (57.1) N2c 26 (14.2) 14 (17.9) 12 (11.4) N3 5 (2.7) 3 (3.8) 2 (1.9) Overall stage Stage III 28 (15.3) 10 (12.8) 18 (17.1) Stage IV 155 (84.7) 68 (87.2) 87 (82.9) Primary tumor site Tonsil 103 (56.2) 41 (53.0) 62 (60.0) BOT 76 (41.5) 35 (44.9) 41 (39.0) Other 2 (1.1) 1 (1.3) 1 (0.95) Unknown 2 (1.1) 1 (1.3) 1 (0.95) Treatment CRT 132 (72.1) 57 (73.1) 75 (71.4) Operation 12 (6.6) 5 (6.4) 7 (6.7) Operation + MMT 39 (21.3) 16 (20.5) 23 (21.9) Note:—Py indicates pack-year; BOT, base of tongue; CRT, chemoradiotherapy; MMT, multimodality therapy.
↵a No statistically significant correlation was found among any of the listed clinical and demographic variables compared with solid/cystic nodal status.
Site (n = 42) No. (%) Local 3 (7.1) Regional 7 (16.7) Distant 19 (45.2) Local and regional 6 (14.3) Local and distant 1 (2.4) Regional and distant 3 (7.1) Local, regional, and distant 3 (7.1)
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