Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleAdult Brain
Open Access

Comparison of Gadoterate Meglumine and Gadobutrol in the MRI Diagnosis of Primary Brain Tumors: A Double-Blind Randomized Controlled Intraindividual Crossover Study (the REMIND Study)

K.R. Maravilla, D. San-Juan, S.J. Kim, G. Elizondo-Riojas, J.R. Fink, W. Escobar, A. Bag, D.R. Roberts, J. Hao, C. Pitrou, A.J. Tsiouris, E. Herskovits and J.B. Fiebach
American Journal of Neuroradiology September 2017, 38 (9) 1681-1688; DOI: https://doi.org/10.3174/ajnr.A5316
K.R. Maravilla
aFrom the Department of Radiology (K.R.M., J.R.F.), University of Washington Medical Center, Seattle, Washington
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K.R. Maravilla
D. San-Juan
bClinical Research Department (D.S.-J.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. San-Juan
S.J. Kim
cDepartment of Radiology (S.J.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.J. Kim
G. Elizondo-Riojas
dUniversidad Autonoma de Nuevo Leon (G.E.-R.), Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey, Mexico
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Elizondo-Riojas
J.R. Fink
aFrom the Department of Radiology (K.R.M., J.R.F.), University of Washington Medical Center, Seattle, Washington
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.R. Fink
W. Escobar
eCentro Medico Imbanaco (W.E.), Cali, Colombia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W. Escobar
A. Bag
fDepartment of Radiology (A.B.), University of Alabama, Birmingham, Alabama
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Bag
D.R. Roberts
gMedical University of South Carolina (D.R.R.), Charleston, South Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.R. Roberts
J. Hao
hGuerbet (J.H., C.P.), Roissy–Charles de Gaulle, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Hao
C. Pitrou
hGuerbet (J.H., C.P.), Roissy–Charles de Gaulle, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Pitrou
A.J. Tsiouris
iDepartment of Radiology (A.J.T.), Weill Cornell Medical College, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.J. Tsiouris
E. Herskovits
jDepartment of Radiology (E.H.), University of Maryland, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Herskovits
J.B. Fiebach
kCenter for Stroke Research Berlin (J.B.F.), Charité-Universitätsmedizin, Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.B. Fiebach
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Rohrer M,
    2. Bauer H,
    3. Mintorovitch J, et al
    . Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005;40:715–24 doi:10.1097/01.rli.0000184756.66360.d3 pmid:16230904
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Anzalone N,
    2. Scarabino T,
    3. Venturi C, et al
    . Cerebral neoplastic enhancing lesions: multicenter, randomized, crossover intraindividual comparison between gadobutrol (1.0M) and gadoterate meglumine (0.5M) at 0.1 mmol Gd/kg body weight in a clinical setting. Eur J Radiol 2013;82:139–45 doi:10.1016/j.ejrad.2011.07.005 pmid:21890295
    CrossRefPubMed
  3. 3.↵
    1. Maravilla KR,
    2. Smith MP,
    3. Vymazal J, et al
    . Are there differences between macrocyclic gadolinium contrast agents for brain tumor imaging? Results of a multicenter intraindividual crossover comparison of gadobutrol with gadoteridol (the TRUTH study). AJNR Am J Neuroradiol 2015;36:14–23 doi:10.3174/ajnr.A4154 pmid:25300984
    Abstract/FREE Full Text
  4. 4.↵
    1. Katakami N,
    2. Inaba Y,
    3. Sugata S, et al
    . Magnetic resonance evaluation of brain metastases from systemic malignances with two doses of gadobutrol 1.0 m compared with gadoteridol: a multicenter, phase ii/iii study in patients with known or suspected brain metastases. Invest Radiol 2011;46:411–18 doi:10.1097/RLI.0b013e3182145a6c pmid:21467949
    CrossRefPubMed
  5. 5.↵
    1. Oudkerk M,
    2. Sijens PE,
    3. Van Beek EJ, et al
    . Safety and efficacy of Dotarem (Gd-DOTA) versus Magnevist (Gd-DTPA) in magnetic resonance imaging of the central nervous system. Invest Radiol 1995;30:75–78 doi:10.1097/00004424-199502000-00002 pmid:7782190
    CrossRefPubMed
  6. 6.↵
    1. Desché P
    . Re: cerebral neoplastic enhancing lesions—multicenter, randomized, crossover intraindividual comparison between gadobutrol (1.0M) and gadoterate meglumine (0.5M) at 0.1 mmol Gd/kg body weight in a clinical setting. Eur J Radiol 2012;81:e967; author reply 2925–26 doi:10.1016/j.ejrad.2012.04.015 pmid:22578838
    CrossRefPubMed
  7. 7.↵
    1. de Kerviler E,
    2. Maravilla K,
    3. Meder JF, et al
    . Adverse reactions to gadoterate meglumine: review of over 25 years of clinical use and more than 50 million doses. Invest Radiol 2016;51:544–51 doi:10.1097/RLI.0000000000000276 pmid:27504794
    CrossRefPubMed
  8. 8.↵
    1. Endrikat J,
    2. Vogtlaender K,
    3. Dohanish S, et al
    . Safety of gadobutrol: results from 42 clinical phase II to IV studies and postmarketing surveillance after 29 million applications. Invest Radiol 2016;51:537–43 doi:10.1097/RLI.0000000000000270 pmid:26964075
    CrossRefPubMed
  9. 9.↵
    1. Grobner T
    . Gadolinium–a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Nephrol Dial Transplant 2006;21:1104–08 pmid:16431890
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Marckmann P,
    2. Skov L,
    3. Rossen K, et al
    . Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging. J Am Soc Nephrol 2006;17:2359–62 doi:10.1681/ASN.2006060601 pmid:16885403
    Abstract/FREE Full Text
  11. 11.↵
    1. Kanda T,
    2. Ishii K,
    3. Kawaguchi H, et al
    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270:834–41 doi:10.1148/radiol.13131669 pmid:24475844
    CrossRefPubMed
  12. 12.↵
    1. Kanda T,
    2. Fukusato T,
    3. Matsuda M, et al
    . Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy. Radiology 2015;276:228–32 doi:10.1148/radiol.2015142690 pmid:25942417
    CrossRefPubMed
  13. 13.↵
    1. McDonald RJ,
    2. McDonald JS,
    3. Kallmes DF, et al
    . Intracranial gadolinium deposition after contrast-enhanced MR imaging. Radiology 2015;275:772–82 doi:10.1148/radiol.15150025 pmid:25742194
    CrossRefPubMed
  14. 14.↵
    1. Radbruch A,
    2. Weberling LD,
    3. Kieslich PJ, et al
    . Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 2015;275:783–91 doi:10.1148/radiol.2015150337 pmid:25848905
    CrossRefPubMed
  15. 15.↵
    1. Radbruch A,
    2. Haase R,
    3. Kieslich PJ, et al
    . No signal intensity increase in the dentate nucleus on unenhanced T1-weighted MR images after more than 20 serial injections of macrocyclic gadolinium-based contrast agents. Radiology 2017;282:699–707 doi:10.1148/radiol.2016162241 pmid:27925871
    CrossRefPubMed
  16. 16.↵
    1. Cao Y,
    2. Huang DQ,
    3. Shih G, et al
    . Signal change in the dentate nucleus on T1-weighted MR images after multiple administrations of gadopentetate dimeglumine versus gadobutrol. AJR Am J Roentgenol 2016;206:414–19 doi:10.2214/AJR.15.15327 pmid:26700156
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 38 (9)
American Journal of Neuroradiology
Vol. 38, Issue 9
1 Sep 2017
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Comparison of Gadoterate Meglumine and Gadobutrol in the MRI Diagnosis of Primary Brain Tumors: A Double-Blind Randomized Controlled Intraindividual Crossover Study (the REMIND Study)
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
K.R. Maravilla, D. San-Juan, S.J. Kim, G. Elizondo-Riojas, J.R. Fink, W. Escobar, A. Bag, D.R. Roberts, J. Hao, C. Pitrou, A.J. Tsiouris, E. Herskovits, J.B. Fiebach
Comparison of Gadoterate Meglumine and Gadobutrol in the MRI Diagnosis of Primary Brain Tumors: A Double-Blind Randomized Controlled Intraindividual Crossover Study (the REMIND Study)
American Journal of Neuroradiology Sep 2017, 38 (9) 1681-1688; DOI: 10.3174/ajnr.A5316

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Comparison of Gadoterate Meglumine and Gadobutrol in the MRI Diagnosis of Primary Brain Tumors: A Double-Blind Randomized Controlled Intraindividual Crossover Study (the REMIND Study)
K.R. Maravilla, D. San-Juan, S.J. Kim, G. Elizondo-Riojas, J.R. Fink, W. Escobar, A. Bag, D.R. Roberts, J. Hao, C. Pitrou, A.J. Tsiouris, E. Herskovits, J.B. Fiebach
American Journal of Neuroradiology Sep 2017, 38 (9) 1681-1688; DOI: 10.3174/ajnr.A5316
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Impact of Kidney Function on CNS Gadolinium Deposition in Patients Receiving Repeated Doses of Gadobutrol
  • Comparison of Dynamic Contrast-Enhancement Parameters between Gadobutrol and Gadoterate Meglumine in Posttreatment Glioma: A Prospective Intraindividual Study
  • Crossref (19)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Current and Future MR Contrast Agents
    Eric Lancelot, Jean-Sébastien Raynaud, Pierre Desché
    Investigative Radiology 2020 55 9
  • Gadobutrol: A Review in Contrast-Enhanced MRI and MRA
    Lesley J. Scott
    Clinical Drug Investigation 2018 38 8
  • 20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease
    Ezekiel Gonzalez-Fernandez, Daniel Staursky, Kathryn Lucas, Bond V. Nguyen, Man Li, Yedan Liu, Chad Washington, Lique M. Coolen, Fan Fan, Richard J. Roman
    Frontiers in Neurology 2020 11
  • Patterns of use, effectiveness and safety of gadolinium contrast agents: a European prospective cross-sectional multicentre observational study
    Jarl Åsbjørn Jakobsen, Carlo Cosimo Quattrocchi, Frank H. H. Müller, Olivier Outteryck, Andrés Alcázar, Wolfgang Reith, Patricia Fraga, Valeria Panebianco, Alexis Sampedro, Radoslaw Pietura
    BMC Medical Imaging 2021 21 1
  • Endohedral Gd-Containing Fullerenol: Toxicity, Antioxidant Activity, and Regulation of Reactive Oxygen Species in Cellular and Enzymatic Systems
    Ekaterina S. Sushko, Natalia G. Vnukova, Grigoriy N. Churilov, Nadezhda S. Kudryasheva
    International Journal of Molecular Sciences 2022 23 9
  • An overview of the intracellular localization of high-Z nanoradiosensitizers
    Mohammad Varzandeh, Sheyda Labbaf, Jaleh Varshosaz, Sophie Laurent
    Progress in Biophysics and Molecular Biology 2022 175
  • Synthesis, Mass Spectroscopy Detection, and Density Functional Theory Investigations of the Gd Endohedral Complexes of C82 Fullerenols
    Anastasia A. Shakirova, Felix N. Tomilin, Vladimir A. Pomogaev, Natalia G. Vnukova, Grigory N. Churilov, Nadezhda S. Kudryasheva, Olga N. Tchaikovskaya, Sergey G. Ovchinnikov, Pavel V. Avramov
    Computation 2021 9 5
  • Gadolinium-based contrast agents for imaging of the central nervous system: A multicenter European prospective study
    Ashkan Heshmatzadeh Behzadi, Jennifer McDonald
    Medicine 2022 101 34
  • Image quality of late gadolinium enhancement in cardiac magnetic resonance with different doses of contrast material in patients with chronic myocardial infarction
    Caterina Beatrice Monti, Marina Codari, Andrea Cozzi, Marco Alì, Lorenzo Saggiante, Francesco Sardanelli, Francesco Secchi
    European Radiology Experimental 2020 4 1
  • Effects of Endohedral Gd-Containing Fullerenols with a Different Number of Oxygen Substituents on Bacterial Bioluminescence
    Evsei A. Stepin, Ekaterina S. Sushko, Natalia G. Vnukova, Grigoriy N. Churilov, Anastasia V. Rogova, Felix N. Tomilin, Nadezhda S. Kudryasheva
    International Journal of Molecular Sciences 2024 25 2

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Segmentation of Brain Metastases with BLAST
  • NCCT vs. MRI for Brain Atrophy in Acute Stroke
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire