Article Figures & Data
Figures
- Fig 1.
Flow chart showing the patient-selection criteria. PFT indicates posterior fossa tumor.
- Fig 2.
T1-weighted images acquired before (A and C) and after 20 gadobenate injections (B and D) in a patient with follow-up for optic glioma without radiation or chemotherapy (A and B) and a patient with medulloblastoma after an operation and radiochemotherapy (C and D). Subtle signal changes of the dentate (arrows) can be seen in the patient without any therapy, while the patient with RCTX shows distinct T1 signal changes of the dentate and perifocal edema.
- Fig 3.
T1-weighted images acquired before (A and C) and after 10 gadobenate injections (B and D) in a patient being followed for a mass at the craniocervical junction with only surgical therapy (A and B) and a patient with medulloblastoma after an operation and radiochemotherapy (C and D). No signal change can be seen in the dentate for the patient without RCTX, while the patient with RCTX already shows signal changes after 10 injections.
- Fig 4.
Distribution of the signal ratio change of the globus pallidus compared with the thalamus (globus pallidus to thalamus) in children with no treatment variables (gray bars) and children with radiochemotherapy (black bars) shows a shift/tendency to higher ratio changes in children with posterior fossa tumors under therapy.
- Fig 5.
Scatterplot showing the correlation between cumulative gadolinium doses and signal ratio change for patients with and without therapy.
Tables
Patient characteristicsa
Unconfounded Cases Posterior Fossa Tumors P Value Total No. of patients 60 16 Age (yr) 8.7 (6–14) 7.8 (4–10) .095 Sex: female 30 (50.0%) 6 (37.5%) .543 Contrast-enhanced MRIs 7 (5–9) 14.5 (11.2–16) <.001 First-to-last MRI with contrast (yr) 3.1 (1.3–4.7) 3.4 (1.4–4.7) .794 Accumulated dose of gadoterate dimeglumine (mL) 48.5 (31.1–87.2) 63.8 (49.8–130.5) .161 Mean ratio change of dentate to pons 0.028 (0.007–0.049) 0.090 (0.049–0.132) <.001 Mean ratio change of globus pallidus to thalamus 0.034 (0.013–0.055) 0.130 (0.091–0.168) <.001 Note:—min indicates minimum; max, maximum.
↵a Data are presented as means with 95% confidence intervals in parentheses.
