Article Figures & Data
Figures
- Fig 1.
ROI placements in supraventricular levels on ASL and SPECT. We drew the ROIs in the bilateral anterior cerebral artery territories and anterior and posterior MCA territories in TCF (A), ATT (B), baseline SPECT (C), and acetazolamide challenge SPECT (D). We also drew an ROI in the ipsilateral cerebellum with the highest uptake on visual assessment for normalization of SPECT values.
- Fig 2.
A representative case of the use of the TCF and ATT maps in depicting CVR impairment. TOF MRA (A) demonstrates left proximal MCA occlusion. Basal/acetazolamide Tc99m-HMPAO SPECT images (B and C) show normal perfusion on basal SPECT and decreased perfusion in the left frontal lobe (MCA M2, superior division territory) on acetazolamide challenge SPECT, which indicates impairment of the CVR in this region. In ASL without a time correction (D), there is no hypoperfusion; however, TCF from MP-ASL (E) demonstrates decreased perfusion and delayed ATT (F).
- Fig 3.
Scatterplots and Pearson correlation coefficients between values of ASL and SPECT of MCA territories (the asterisk indicates P < .001; double asterisks, P = .007).
Tables
ASL Parameters Absolute Values Contralateral Unaffected ROIs Ipsilateral Affected ROIs P TCF (mL/100 g/min) 46.00 ± 8.89 34.81 ± 14.58 <.001 ATT (ms) 1235.49 ± 142.40 1643.71 ± 240.03 <.001 ↵a Values are means.
Mean Area under ROC Curve Associated Criterion Sensitivity Specificity P TCF (mL/100 g/min) 40.40 ± 13.27a 0.822 (0.747–0.882)b ≤33.00 62.00 93.02 <.001 Percentage change of TCF (%) 12.55 ± 21.86a 0.905 (0.843–0.949)b >7.14 84.00 97.67 <.001 ATT (ms) 1439.59 ± 283.95a 0.891 (0.826–0.938)b >1527 82.00 88.37 <.001 Percentage change of ATT (%) −17.57 ± 26.24a 0.889 (0.823–0.936)b ≤−8.86 94.00 87.21 <.001
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