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Figures
- Fig 1.
Representative views of OEFRs averaged over Destrieux parcellations, T1-anatomy, and cortical thickness on inflated surface maps. A–D, Four patients without infarction or hemorrhage were selected randomly from the patient cohort for visualization. E, This patient exemplifies the rationale for excluding infarcted hemispheres. Extensive encephalomalacia distorts cortical parcellations and confounds calculations on cortical and pial anatomy by FreeSurfer (arrows). F, This patient demonstrates paradoxically decreased OEFR around a region of infarction (arrows). The validity and significance of such decreases near infarcted areas are unknown. Consequently, all hemispheres ipsilateral to infarctions or hemorrhages were excluded. Modal color maps are identical for all subfigures and views.
- Fig 2.
A, Histogram of OEFR from Destrieux FreeSurfer regions within MCA vascular territories from 15 historically obtained healthy control subjects. Superimposed is the histogram of OEFR from anatomically corresponding regions from 35 patients with Moyamoya phenomenon. Following applying exclusion criteria, there are 900 regions from controls and 3420 regions from patients. B, Histogram of cortical thickness from the same 3420 MCA regions in patients with Moyamoya phenomenon.
- Fig 3.
Plots of data arranged by granularity of measurements (FreeSurfer regions, hemispheres, patients) in columns and mappings of predictors (OEFR, age, sex, and time from symptom onset to scanning) of cortical thickness in rows. For sex, male = 0 and female = 1. The color map indicates patient identities. Lines of regression between model parameters and cortical thickness correspond to significant predictors. ρ denotes the partial correlation coefficient between the plotted parameter and cortical thickness. The top-left panel excludes a data point with OEFR = 0.479 and 4 data points with an OEFR of >2 to clarify the distribution of regional data with respect to OEFR and thickness. All plots exclude regions and hemispheres ipsilateral to infarctions or hemorrhages as detailed in the Materials and Methods.
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