Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Review ArticleAdult Brain
Open Access

Gadolinium and Multiple Sclerosis: Vessels, Barriers of the Brain, and Glymphatics

C. Saade, R. Bou-Fakhredin, D.M. Yousem, K. Asmar, L. Naffaa and F. El-Merhi
American Journal of Neuroradiology December 2018, 39 (12) 2168-2176; DOI: https://doi.org/10.3174/ajnr.A5773
C. Saade
aFrom the Diagnostic Radiology Department (C.S., R.B.-F., K.A., L.N., F.E.-M.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Saade
R. Bou-Fakhredin
aFrom the Diagnostic Radiology Department (C.S., R.B.-F., K.A., L.N., F.E.-M.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Bou-Fakhredin
D.M. Yousem
bThe Russell H. Morgan Department of Radiology and Radiological Science (D.M.Y.), Neuroradiology Division, Johns Hopkins Hospital, Baltimore, Maryland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.M. Yousem
K. Asmar
aFrom the Diagnostic Radiology Department (C.S., R.B.-F., K.A., L.N., F.E.-M.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Asmar
L. Naffaa
aFrom the Diagnostic Radiology Department (C.S., R.B.-F., K.A., L.N., F.E.-M.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Naffaa
F. El-Merhi
aFrom the Diagnostic Radiology Department (C.S., R.B.-F., K.A., L.N., F.E.-M.), American University of Beirut Medical Center, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F. El-Merhi
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Information

vol. 39 no. 12 2168-2176
DOI 
https://doi.org/10.3174/ajnr.A5773
PubMed 
30385472

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received August 25, 2017
  • Accepted after revision June 5, 2018
  • Published online December 14, 2018.

Copyright & Usage 
© 2018 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. C. Saadea,
  2. R. Bou-Fakhredina,
  3. D.M. Yousemb,
  4. K. Asmara,
  5. L. Naffaaa and
  6. F. El-Merhia
  1. aFrom the Diagnostic Radiology Department (C.S., R.B.-F., K.A., L.N., F.E.-M.), American University of Beirut Medical Center, Beirut, Lebanon
  2. bThe Russell H. Morgan Department of Radiology and Radiological Science (D.M.Y.), Neuroradiology Division, Johns Hopkins Hospital, Baltimore, Maryland.
  1. Please address correspondence to Fadi El-Merhi, MD, ABR, Diagnostic Radiology Department, American University of Beirut Medical Center, Beirut, Lebanon, PO Box 11–0236 Riad El-Solh, Beirut, 1107 2020, Lebanon; e-mail: fe19{at}aub.edu.lb
View Full Text

Altmetrics

Cited By...

  • 28 Citations
  • 32 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Reviewing the Significance of Blood–Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment
    Rodica Balasa, Laura Barcutean, Oana Mosora, Doina Manu
    International Journal of Molecular Sciences 2021 22 16
  • From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
    Julie Ouellette, Baptiste Lacoste
    Frontiers in Aging Neuroscience 2021 13
  • Contrast-to-Dose Relationship of Gadopiclenol, an MRI Macrocyclic Gadolinium-based Contrast Agent, Compared with Gadoterate, Gadobenate, and Gadobutrol in a Rat Brain Tumor Model
    Philippe Robert, Véronique Vives, Anne-Laure Grindel, Stéphane Kremer, Guillaume Bierry, Gaelle Louin, Sébastien Ballet, Claire Corot
    Radiology 2020 294 1
  • Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine
    Shuangqing Wang, Bernhard Hesse, Marco Roman, Deborah Stier, Hiram Castillo-Michel, Marine Cotte, Jussi-Petteri Suuronen, Adrien Lagrange, Helena Radbruch, Friedemann Paul, Matthias Taupitz, Eyk Schellenberger, Ingolf Sack, Carmen Infante-Duarte
    Investigative Radiology 2019 54 10
  • Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound
    Seung-Schik Yoo, Hyun-Chul Kim, Jaeho Kim, Evgenii Kim, Kavin Kowsari, Jared Van Reet, Kyungho Yoon
    Scientific Reports 2022 12 1
  • Pediatric multiple sclerosis: from clinical basis to imaging spectrum and differential diagnosis
    Igor G. Padilha, Ana P. A. Fonseca, Ana L. M. Pettengill, Diego C. Fragoso, Felipe T. Pacheco, Renato H. Nunes, Antonio C. M. Maia, Antônio J. da Rocha
    Pediatric Radiology 2020 50 6
  • Use of gadolinium-based contrast agents in multiple sclerosis: a review by the ESMRMB-GREC and ESNR Multiple Sclerosis Working Group
    Àlex Rovira, Fabio M. Doniselli, Cristina Auger, Lukas Haider, Jerome Hodel, Mariasavina Severino, Mike P. Wattjes, Aart J. van der Molen, Bas Jasperse, Carlo A. Mallio, Tarek Yousry, Carlo C. Quattrocchi
    European Radiology 2023 34 3
  • Magnetic resonance imaging diagnosis of demyelinating diseases: An update
    Yukio Miki
    Clinical and Experimental Neuroimmunology 2019 10 S1
  • The glymphatic system and multiple sclerosis: An evolving connection
    Alaa Alghanimy, Lorraine M. Work, William M. Holmes
    Multiple Sclerosis and Related Disorders 2024 83
  • El sistema glinfático y su implicación en las enfermedades del sistema nervioso
    María Toriello, Vicente González-Quintanilla, Julio Pascual
    Medicina Clínica 2021 156 7
  • The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis
    Ingrid Anne Lie, Emma Kerklingh, Kristin Wesnes, David R. van Nederpelt, Iman Brouwer, Øivind Torkildsen, Kjell-Morten Myhr, Frederik Barkhof, Lars Bø, Hugo Vrenken
    European Radiology 2022 32 5
  • Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis
    Riccardo Nistri, Antonio Ianniello, Valeria Pozzilli, Costanza Giannì, Carlo Pozzilli
    Diagnostics 2024 14 11
  • Clinical applications, safety profiles, and future developments of contrast agents in modern radiology: A comprehensive review
    Reabal Najjar
    iRADIOLOGY 2024 2 5
  • Decreased Astrocytic CCL2 Accounts for BAF-312 Effect on PBMCs Transendothelial Migration Through a Blood Brain Barrier in Vitro Model
    Simona F. Spampinato, Sara Merlo, Giuseppe Costantino, Yasuteru Sano, Takashi Kanda, Maria Angela Sortino
    Journal of Neuroimmune Pharmacology 2022 17 3-4
  • Imaging of the meningeal lymphatic network in healthy adults: A 7T MRI study
    Lakir D. Patel, Prashant Raghavan, Shiyu Tang, Seongjin Choi, Daniel M. Harrison
    Journal of Neuroradiology 2023 50 4
  • Teriflunomide Promotes Blood–Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple Sclerosis
    Yipeng Zhao, Chen Chen, Xiuqing Xiao, Ling Fang, Xi Cheng, Yanyu Chang, Fuhua Peng, Jingqi Wang, Shishi Shen, Shilin Wu, Yiying Huang, Wei Cai, Linli Zhou, Wei Qiu
    Molecular Neurobiology 2024 61 4
  • Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease
    Juan F. Osuna-Ramos, Josué Camberos-Barraza, Laura E. Torres-Mondragón, Ángel R. Rábago-Monzón, Alejandro Camacho-Zamora, Marco A. Valdez-Flores, Carla E. Angulo-Rojo, Alma M. Guadrón-Llanos, Verónica J. Picos-Cárdenas, Loranda Calderón-Zamora, Javier A. Magaña-Gómez, Claudia D. Norzagaray-Valenzuela, Feliznando I. Cárdenas-Torres, Alberto K. De la Herrán-Arita
    International Journal of Molecular Sciences 2023 24 24
  • Ultra-High Contrast MRI: Using Divided Subtracted Inversion Recovery (dSIR) and Divided Echo Subtraction (dES) Sequences to Study the Brain and Musculoskeletal System
    Daniel Cornfeld, Paul Condron, Gil Newburn, Josh McGeown, Miriam Scadeng, Mark Bydder, Mark Griffin, Geoffrey Handsfield, Meeghage Randika Perera, Tracy Melzer, Samantha Holdsworth, Eryn Kwon, Graeme Bydder
    Bioengineering 2024 11 5
  • Evaluation of sleep-related respiratory disorders in patients with multiple sclerosis
    Hikmet Saçmacı, Nermin Tanık, Seda Sabah Özcan, Yavuz Selim İntepe, Tülin Aktürk, Bülent Çiftçi, Levent Ertuğrul İnan
    Acta Neurologica Belgica 2020 120 5
  • Impact of post-contrast MRI in the definition of active multiple sclerosis
    Lucia Gentili, Rocco Capuano, Lorenzo Gaetani, Andrea Fiacca, Alvino Bisecco, Alessandro d'Ambrosio, Andrea Mancini, Giorgio Guercini, Gioacchino Tedeschi, Lucilla Parnetti, Antonio Gallo, Massimiliano Di Filippo
    Journal of the Neurological Sciences 2022 440
  • Investigating the feasibility of differentiating MS active lesions from inactive ones using texture analysis and machine learning methods in DWI images
    Farshad Shekari, Alireza Vard, Iman Adibi, Safieh Danesh-Mobarhan
    Multiple Sclerosis and Related Disorders 2024 82
  • Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review
    Hibba Yousef, Brigitta Malagurski Tortei, Filippo Castiglione
    Journal of Neurology 2024 271 10
  • Research Progress on Intracranial Lymphatic Circulation and Its Involvement in Disorders
    Fan Chen, Xuan Xie, Liang Wang
    Frontiers in Neurology 2022 13
  • Automatic Active Lesion Tracking in Multiple Sclerosis Using Unsupervised Machine Learning
    Jason Uwaeze, Ponnada Narayana, Arash Kamali, Vladimir Braverman, Michael Jacobs, Alireza Akhbardeh
    Diagnostics 2024 14 6
  • The glymphatic system and its involvement in disorders of the nervous system
    María Toriello, Vicente González-Quintanilla, Julio Pascual
    Medicina Clínica (English Edition) 2021 156 7
  • Treatment Monitoring in Multiple Sclerosis — Efficacy and Safety
    Nima Mahmoudi, Mike P. Wattjes
    Neuroimaging Clinics of North America 2024 34 3
  • Changes of brain parenchyma free water fraction reflect tissue damage and impaired processing speed in multiple sclerosis
    Alessandra Stella Caporale, Antonio Maria Chiarelli, Emma Biondetti, Alessandro Villani, Ilona Lipp, Davide Di Censo, Valentina Tomassini, Richard Geoffrey Wise
    Human Brain Mapping 2024 45 9
  • Diffusion-Weighted Images and Contrast-Enhanced MRI in the Diagnosis of Different Stages of Multiple Sclerosis of the Central Nervous System
    Mashael A Ismail, Naglaa M Elsayed
    Cureus 2023
  • Efficacy and safety of peginterferon beta-1a compared to interferon beta-1a in relapsing remitting multiple sclerosis patients: A phase 3, randomized, non-inferiority clinical trial (PEGINTEGRITY)
    Vahid Shaygannejad, Fereshteh Ashtari, Morteza Saeidi, Nahid Beladi Moghadam, Hamidreza Ghalyanchi Langroodi, Seyed Mohammad Baghbanian, Roya Abolfazli, Masoud Ghiasian, Hormoz Ayromlou, Elnaz Asadollahzadeh, Araz Sabzvari, Hamidreza Kafi, Amirreza Azimi Saeen
    Multiple Sclerosis and Related Disorders 2024 90
  • Multiple Sclerosis
    Phuong Nguyen, Torge Rempe, Reza Forghani
    Magnetic Resonance Imaging Clinics of North America 2024 32 2
  • Neuroimmunology
    Jordon Dunham, Kedar R. Mahajan
    2021
  • WITHDRAWN: The effect of macrocyclic ionic and non-ionic gadolinium agents on neuronal injury and myelin loss in the spinal cords of rats with and without diabetes mellitus
    Sarah H. Al Moussawi, Youssef Ghosn, Lina Karout, Yara Jabbour, Assad A. Eid, Charbel Saade
    Magnetic Resonance Imaging 2024
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 39 (12)
American Journal of Neuroradiology
Vol. 39, Issue 12
1 Dec 2018
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Gadolinium and Multiple Sclerosis: Vessels, Barriers of the Brain, and Glymphatics
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
C. Saade, R. Bou-Fakhredin, D.M. Yousem, K. Asmar, L. Naffaa, F. El-Merhi
Gadolinium and Multiple Sclerosis: Vessels, Barriers of the Brain, and Glymphatics
American Journal of Neuroradiology Dec 2018, 39 (12) 2168-2176; DOI: 10.3174/ajnr.A5773

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Gadolinium and Multiple Sclerosis: Vessels, Barriers of the Brain, and Glymphatics
C. Saade, R. Bou-Fakhredin, D.M. Yousem, K. Asmar, L. Naffaa, F. El-Merhi
American Journal of Neuroradiology Dec 2018, 39 (12) 2168-2176; DOI: 10.3174/ajnr.A5773
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Glymphatic Insights in Glioblastoma
  • Crossref (32)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Reviewing the Significance of Blood–Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment
    Rodica Balasa, Laura Barcutean, Oana Mosora, Doina Manu
    International Journal of Molecular Sciences 2021 22 16
  • From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
    Julie Ouellette, Baptiste Lacoste
    Frontiers in Aging Neuroscience 2021 13
  • Contrast-to-Dose Relationship of Gadopiclenol, an MRI Macrocyclic Gadolinium-based Contrast Agent, Compared with Gadoterate, Gadobenate, and Gadobutrol in a Rat Brain Tumor Model
    Philippe Robert, Véronique Vives, Anne-Laure Grindel, Stéphane Kremer, Guillaume Bierry, Gaelle Louin, Sébastien Ballet, Claire Corot
    Radiology 2020 294 1
  • Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine
    Shuangqing Wang, Bernhard Hesse, Marco Roman, Deborah Stier, Hiram Castillo-Michel, Marine Cotte, Jussi-Petteri Suuronen, Adrien Lagrange, Helena Radbruch, Friedemann Paul, Matthias Taupitz, Eyk Schellenberger, Ingolf Sack, Carmen Infante-Duarte
    Investigative Radiology 2019 54 10
  • Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound
    Seung-Schik Yoo, Hyun-Chul Kim, Jaeho Kim, Evgenii Kim, Kavin Kowsari, Jared Van Reet, Kyungho Yoon
    Scientific Reports 2022 12 1
  • Pediatric multiple sclerosis: from clinical basis to imaging spectrum and differential diagnosis
    Igor G. Padilha, Ana P. A. Fonseca, Ana L. M. Pettengill, Diego C. Fragoso, Felipe T. Pacheco, Renato H. Nunes, Antonio C. M. Maia, Antônio J. da Rocha
    Pediatric Radiology 2020 50 6
  • Use of gadolinium-based contrast agents in multiple sclerosis: a review by the ESMRMB-GREC and ESNR Multiple Sclerosis Working Group
    Àlex Rovira, Fabio M. Doniselli, Cristina Auger, Lukas Haider, Jerome Hodel, Mariasavina Severino, Mike P. Wattjes, Aart J. van der Molen, Bas Jasperse, Carlo A. Mallio, Tarek Yousry, Carlo C. Quattrocchi
    European Radiology 2023 34 3
  • Magnetic resonance imaging diagnosis of demyelinating diseases: An update
    Yukio Miki
    Clinical and Experimental Neuroimmunology 2019 10 S1
  • The glymphatic system and multiple sclerosis: An evolving connection
    Alaa Alghanimy, Lorraine M. Work, William M. Holmes
    Multiple Sclerosis and Related Disorders 2024 83
  • El sistema glinfático y su implicación en las enfermedades del sistema nervioso
    María Toriello, Vicente González-Quintanilla, Julio Pascual
    Medicina Clínica 2021 156 7

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • ML for Glioma Molecular Subtype Prediction
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire