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Research ArticleAdult Brain
Open Access

Addition of Amide Proton Transfer Imaging to FDG-PET/CT Improves Diagnostic Accuracy in Glioma Grading: A Preliminary Study Using the Continuous Net Reclassification Analysis

A. Sakata, T. Okada, Y. Yamamoto, Y. Fushimi, T. Dodo, Y. Arakawa, Y. Mineharu, B. Schmitt, S. Miyamoto and K. Togashi
American Journal of Neuroradiology February 2018, 39 (2) 265-272; DOI: https://doi.org/10.3174/ajnr.A5503
A. Sakata
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (A.S., T.O., Y.F., T.D., K.T.)
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T. Okada
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (A.S., T.O., Y.F., T.D., K.T.)
bBrain Research Center (T.O.)
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Y. Yamamoto
dDepartment of Healthcare Epidemiology (Y.Y.), School of Public Health, Kyoto University Graduate School of Medicine, Kyoto, Japan
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Y. Fushimi
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (A.S., T.O., Y.F., T.D., K.T.)
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T. Dodo
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (A.S., T.O., Y.F., T.D., K.T.)
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Y. Arakawa
cDepartment of Neurosurgery (Y.A., Y.M., S.M.)
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Y. Mineharu
cDepartment of Neurosurgery (Y.A., Y.M., S.M.)
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B. Schmitt
eMagnetic Resonance (B.S.), Siemens Healthcare, Bayswater, Australia.
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S. Miyamoto
cDepartment of Neurosurgery (Y.A., Y.M., S.M.)
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K. Togashi
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (A.S., T.O., Y.F., T.D., K.T.)
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References

  1. 1.↵
    1. Yoon JH,
    2. Kim JH,
    3. Kang WJ, et al
    . Grading of cerebral glioma with multiparametric MR imaging and 18F-FDG-PET: concordance and accuracy. Eur Radiol 2014;24:380–89 doi:10.1007/s00330-013-3019-3 pmid:24078054
    CrossRefPubMed
  2. 2.↵
    1. Chung C,
    2. Metser U,
    3. Ménard C
    . Advances in magnetic resonance imaging and positron emission tomography imaging for grading and molecular characterization of glioma. Semin Radiat Oncol 2015;25:164–71 doi:10.1016/j.semradonc.2015.02.002 pmid:26050586
    CrossRefPubMed
  3. 3.↵
    1. Bai Y,
    2. Lin Y,
    3. Zhang W, et al
    . Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas. Oncotarget 2017;8:5834–42 doi:10.18632/oncotarget.13970 pmid:27992380
    CrossRefPubMed
  4. 4.↵
    1. Higano S,
    2. Yun X,
    3. Kumabe T, et al
    . Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology 2006;241:839–46 doi:10.1148/radiol.2413051276 pmid:17032910
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Murakami R,
    2. Hirai T,
    3. Sugahara T, et al
    . Grading astrocytic tumors by using apparent diffusion coefficient parameters: superiority of a one- versus two-parameter pilot method. Radiology 2009;251:838–45 doi:10.1148/radiol.2513080899 pmid:19318585
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. van Zijl PC,
    2. Yadav NN
    . Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med 2011;65:927–48 doi:10.1002/mrm.22761 pmid:21337419
    CrossRefPubMed
  7. 7.↵
    1. Zaiss M,
    2. Bachert P
    . Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods. Phys Med Biol 2013;58:R221–69 doi:10.1088/0031-9155/58/22/R221 pmid:24201125
    CrossRefPubMed
  8. 8.↵
    1. Vinogradov E,
    2. Sherry AD,
    3. Lenkinski RE
    . CEST: from basic principles to applications, challenges and opportunities. J Magn Reson 2013;229:155–72 doi:10.1016/j.jmr.2012.11.024 pmid:23273841
    CrossRefPubMed
  9. 9.↵
    1. Zhou J,
    2. Payen JF,
    3. Wilson DA, et al
    . Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 2003;9:1085–90 doi:10.1038/nm907 pmid:12872167
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Zhou J,
    2. Lal B,
    3. Wilson DA, et al
    . Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 2003;50:1120–26 doi:10.1002/mrm.10651 pmid:14648559
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Togao O,
    2. Yoshiura T,
    3. Keupp J, et al
    . Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Neuro Oncol 2014;16:441–48 doi:10.1093/neuonc/not158 pmid:24305718
    CrossRefPubMed
  12. 12.↵
    1. Park JE,
    2. Kim HS,
    3. Park KJ, et al
    . Histogram analysis of amide proton transfer imaging to identify contrast-enhancing low-grade brain tumor that mimics high-grade tumor: increased accuracy of MR perfusion. Radiology 2015;277:151–61 doi:10.1148/radiol.2015142347 pmid:25910226
    CrossRefPubMed
  13. 13.↵
    1. Togao O,
    2. Hiwatashi A,
    3. Yamashita K, et al
    . Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. Eur Radiol 2017;27:578–88 doi:10.1007/s00330-016-4328-0 pmid:27003139
    CrossRefPubMed
  14. 14.↵
    1. Park JE,
    2. Kim HS,
    3. Park KJ, et al
    . Pre- and posttreatment glioma: comparison of amide proton transfer imaging with MR spectroscopy for biomarkers of tumor proliferation. Radiology 2016;278:514–23 doi:10.1148/radiol.2015142979 pmid:26491847
    CrossRefPubMed
  15. 15.↵
    1. Sakata A,
    2. Okada T,
    3. Yamamoto A, et al
    . Grading glial tumors with amide proton transfer MR imaging: different analytical approaches. J Neurooncol 2015;122:339–48 doi:10.1007/s11060-014-1715-8 pmid:25559689
    CrossRefPubMed
  16. 16.↵
    1. Choi YS,
    2. Ahn SS,
    3. Lee SK, et al
    . Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume. Eur Radiol 2017;27:3181–89 doi:10.1007/s00330-017-4732-0 pmid:28116517
    CrossRefPubMed
  17. 17.↵
    1. Ma B,
    2. Blakeley JO,
    3. Hong X, et al
    . Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas. J Magn Reson Imaging 2016;44:456–62 doi:10.1002/jmri.25159 pmid:26788865
    CrossRefPubMed
  18. 18.↵
    1. Park KJ,
    2. Kim HS,
    3. Park JE, et al
    . Added value of amide proton transfer imaging to conventional and perfusion MR imaging for evaluating the treatment response of newly diagnosed glioblastoma. Eur Radiol 2016;26:4390–403 doi:10.1007/s00330-016-4261-2 pmid:26883333
    CrossRefPubMed
  19. 19.↵
    1. Sagiyama K,
    2. Mashimo T,
    3. Togao O, et al
    . In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci U S A 2014;111:4542–47 doi:10.1073/pnas.1323855111 pmid:24616497
    Abstract/FREE Full Text
  20. 20.↵
    1. Pencina MJ,
    2. D'Agostino RB Sr.,
    3. D'Agostino RB Jr., et al
    . Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 2008;27:157–72; discussion 207–12 doi:10.1002/sim.2929 pmid:17569110
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Louis DN,
    2. Ohgaki H,
    3. Wiestler OD, et al
    . The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97–109 doi:10.1007/s00401-007-0243-4 pmid:17618441
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Sakata A,
    2. Fushimi Y,
    3. Okada T, et al
    . Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors. J Magn Reson Imaging 2017;46:732–39 doi:10.1002/jmri.25597 pmid:28252822
    CrossRefPubMed
  23. 23.↵
    1. Schmitt B,
    2. Zaiss M,
    3. Zhou J, et al
    . Optimization of pulse train presaturation for CEST imaging in clinical scanners. Magn Reson Med 2011;65:1620–29 doi:10.1002/mrm.22750 pmid:21337418
    CrossRefPubMed
  24. 24.↵
    1. Yamashita K,
    2. Yoshiura T,
    3. Hiwatashi A, et al
    . Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion-weighted imaging, and 18F-fluorodeoxyglucose positron emission tomography. Neuroradiology 2013;55:135–43 doi:10.1007/s00234-012-1089-6 pmid:22961074
    CrossRefPubMed
  25. 25.↵
    1. Manabe O,
    2. Hattori N,
    3. Yamaguchi S, et al
    . Oligodendroglial component complicates the prediction of tumour grading with metabolic imaging. Eur J Nucl Med Mol Imaging 2015;42:896–904 doi:10.1007/s00259-015-2996-7 pmid:25647076
    CrossRefPubMed
  26. 26.↵
    1. Landis JR,
    2. Koch GG
    . The measurement of observer agreement for categorical data. Biometrics 1977;33:159–74 doi:10.2307/2529310 pmid:843571
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. DeLong ER,
    2. DeLong DM,
    3. Clarke-Pearson DL
    . Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988;44:837–45 doi:10.2307/2531595 pmid:3203132
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Schmidt H,
    2. Schwenzer NF,
    3. Gatidis S, et al
    . Systematic evaluation of amide proton chemical exchange saturation transfer at 3T: effects of protein concentration, pH, and acquisition parameters. Invest Radiol 2016;51:635–46 doi:10.1097/RLI.0000000000000292 pmid:27272542
    CrossRefPubMed
  29. 29.↵
    1. Sun PZ,
    2. Wang E,
    3. Cheung JS
    . Imaging acute ischemic tissue acidosis with pH-sensitive endogenous amide proton transfer (APT) MRI: correction of tissue relaxation and concomitant RF irradiation effects toward mapping quantitative cerebral tissue pH. Neuroimage 2012;60:1–6 doi:10.1016/j.neuroimage.2011.11.091 pmid:22178815
    CrossRefPubMed
  30. 30.↵
    1. Fudaba H,
    2. Shimomura T,
    3. Abe T, et al
    . Comparison of multiple parameters obtained on 3T pulsed arterial spin-labeling, diffusion tensor imaging, and MRS and the Ki-67 labeling index in evaluating glioma grading. AJNR Am J Neuroradiol 2014;35:2091–98 doi:10.3174/ajnr.A4018 pmid:24994829
    Abstract/FREE Full Text
  31. 31.↵
    1. Server A,
    2. Kulle B,
    3. Gadmar ØB, et al
    . Measurements of diagnostic examination performance using quantitative apparent diffusion coefficient and proton MR spectroscopic imaging in the preoperative evaluation of tumor grade in cerebral gliomas. Eur J Radiol 2011;80:462–70 doi:10.1016/j.ejrad.2010.07.017 pmid:20708868
    CrossRefPubMed
  32. 32.↵
    1. Nguyen TB,
    2. Cron GO,
    3. Perdrizet K, et al
    . Comparison of the diagnostic accuracy of DSC- and dynamic contrast-enhanced MRI in the preoperative grading of astrocytomas. AJNR Am J Neuroradiol 2015;36:2017–22 doi:10.3174/ajnr.A4398 pmid:26228886
    Abstract/FREE Full Text
  33. 33.↵
    1. Halligan S,
    2. Altman DG,
    3. Mallett S
    . Disadvantages of using the area under the receiver operating characteristic curve to assess imaging tests: a discussion and proposal for an alternative approach. Eur Radiol 2015;25:932–39 doi:10.1007/s00330-014-3487-0 pmid:25599932
    CrossRefPubMed
  34. 34.↵
    1. Rutjes A,
    2. Reitsma J,
    3. Coomarasamy A, et al
    . Evaluation of diagnostic tests when there is no gold standard: a review of methods. Health Technol Assess 2007;11:iii, ix–51 pmid:18021577
    PubMed
  35. 35.↵
    1. Collins VP,
    2. Jones DT,
    3. Giannini C
    . Pilocytic astrocytoma: pathology, molecular mechanisms and markers. Acta Neuropathol 2015;129:775–88 doi:10.1007/s00401-015-1410-7 pmid:25792358
    CrossRefPubMed
  36. 36.↵
    1. de Fatima Vasco Aragao M,
    2. Law M,
    3. Batista de Almeida D, et al
    . Comparison of perfusion, diffusion, and MR spectroscopy between low-grade enhancing pilocytic astrocytomas and high-grade astrocytomas. AJNR Am J Neuroradiol 2014;35:1495–502 doi:10.3174/ajnr.A3905 pmid:24699088
    Abstract/FREE Full Text
  37. 37.↵
    1. Eckel-Passow JE,
    2. Lachance DH,
    3. Molinaro AM, et al
    . Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med 2015;372:2499–508 doi:10.1056/NEJMoa1407279 pmid:26061753
    CrossRefPubMed
  38. 38.↵
    1. Koschmann C,
    2. Calinescu AA,
    3. Nunez FJ, et al
    . ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. Sci Transl Med 2016;8:328ra28 doi:10.1126/scitranslmed.aac8228 pmid:26936505
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 39 (2)
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A. Sakata, T. Okada, Y. Yamamoto, Y. Fushimi, T. Dodo, Y. Arakawa, Y. Mineharu, B. Schmitt, S. Miyamoto, K. Togashi
Addition of Amide Proton Transfer Imaging to FDG-PET/CT Improves Diagnostic Accuracy in Glioma Grading: A Preliminary Study Using the Continuous Net Reclassification Analysis
American Journal of Neuroradiology Feb 2018, 39 (2) 265-272; DOI: 10.3174/ajnr.A5503

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Addition of Amide Proton Transfer Imaging to FDG-PET/CT Improves Diagnostic Accuracy in Glioma Grading: A Preliminary Study Using the Continuous Net Reclassification Analysis
A. Sakata, T. Okada, Y. Yamamoto, Y. Fushimi, T. Dodo, Y. Arakawa, Y. Mineharu, B. Schmitt, S. Miyamoto, K. Togashi
American Journal of Neuroradiology Feb 2018, 39 (2) 265-272; DOI: 10.3174/ajnr.A5503
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