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Research ArticleAdult Brain
Open Access

Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy

L.L. Gramegna, A. Pisano, C. Testa, D.N. Manners, R. D'Angelo, E. Boschetti, F. Giancola, L. Pironi, L. Caporali, M. Capristo, M.L. Valentino, G. Plazzi, C. Casali, M.T. Dotti, G. Cenacchi, M. Hirano, C. Giordano, P. Parchi, R. Rinaldi, R. De Giorgio, R. Lodi, V. Carelli and C. Tonon
American Journal of Neuroradiology March 2018, 39 (3) 427-434; DOI: https://doi.org/10.3174/ajnr.A5507
L.L. Gramegna
aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
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A. Pisano
eDepartments of Radiology, Oncology, and Pathology (A.P., C.G.)
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C. Testa
aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)
bNeurology Unit (R.D., R.R.), S.Orsola-Malpighi Hospital, Bologna, Italy
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
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D.N. Manners
aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
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R. D'Angelo
bNeurology Unit (R.D., R.R.), S.Orsola-Malpighi Hospital, Bologna, Italy
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E. Boschetti
dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy
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F. Giancola
dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy
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L. Pironi
dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy
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L. Caporali
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy
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M. Capristo
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy
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M.L. Valentino
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy
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G. Plazzi
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy
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C. Casali
fMedico-Surgical Sciences and Biotechnologies (C.C.), Sapienza, University of Rome, Rome, Italy
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M.T. Dotti
hDepartment of Medicine, Surgery, and Neuroscience (M.T.D.), University of Siena, Siena, Italy
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G. Cenacchi
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
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M. Hirano
iDepartment of Neurology (M.H.), Columbia University Medical Centre, New York, New York.
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C. Giordano
eDepartments of Radiology, Oncology, and Pathology (A.P., C.G.)
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P. Parchi
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy
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R. Rinaldi
bNeurology Unit (R.D., R.R.), S.Orsola-Malpighi Hospital, Bologna, Italy
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R. De Giorgio
dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy
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R. Lodi
aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
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V. Carelli
cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)
gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy
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C. Tonon
aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)
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American Journal of Neuroradiology: 39 (3)
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Cite this article
L.L. Gramegna, A. Pisano, C. Testa, D.N. Manners, R. D'Angelo, E. Boschetti, F. Giancola, L. Pironi, L. Caporali, M. Capristo, M.L. Valentino, G. Plazzi, C. Casali, M.T. Dotti, G. Cenacchi, M. Hirano, C. Giordano, P. Parchi, R. Rinaldi, R. De Giorgio, R. Lodi, V. Carelli, C. Tonon
Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy
American Journal of Neuroradiology Mar 2018, 39 (3) 427-434; DOI: 10.3174/ajnr.A5507

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Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy
L.L. Gramegna, A. Pisano, C. Testa, D.N. Manners, R. D'Angelo, E. Boschetti, F. Giancola, L. Pironi, L. Caporali, M. Capristo, M.L. Valentino, G. Plazzi, C. Casali, M.T. Dotti, G. Cenacchi, M. Hirano, C. Giordano, P. Parchi, R. Rinaldi, R. De Giorgio, R. Lodi, V. Carelli, C. Tonon
American Journal of Neuroradiology Mar 2018, 39 (3) 427-434; DOI: 10.3174/ajnr.A5507
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