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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Quantitative Phase-Contrast MR Angiography to Measure Hemodynamic Changes in Idiopathic Intracranial Hypertension

J. Juhász, T. Lindner, C. Riedel, N.G. Margraf, O. Jansen and A. Rohr
American Journal of Neuroradiology April 2018, 39 (4) 682-686; DOI: https://doi.org/10.3174/ajnr.A5571
J. Juhász
aFrom the Clinic for Radiology and Neuroradiology (J.J., T.L., C.R., O.J., A.R.)
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  • ORCID record for J. Juhász
T. Lindner
aFrom the Clinic for Radiology and Neuroradiology (J.J., T.L., C.R., O.J., A.R.)
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  • ORCID record for T. Lindner
C. Riedel
aFrom the Clinic for Radiology and Neuroradiology (J.J., T.L., C.R., O.J., A.R.)
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N.G. Margraf
bClinic for Neurology (N.G.M.), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
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  • ORCID record for N.G. Margraf
O. Jansen
aFrom the Clinic for Radiology and Neuroradiology (J.J., T.L., C.R., O.J., A.R.)
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A. Rohr
aFrom the Clinic for Radiology and Neuroradiology (J.J., T.L., C.R., O.J., A.R.)
cNeuroradiology Section (A.R.), Vancouver General Hospital, Vancouver, British Columbia, Canada.
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    Fig 1.

    A, Slice positioning of the quantitative phase-contrast angiography measurements. Each slab was acquired twice, first with a velocity-encoding of 40 cm/s to visualize venous outflow and then with 100 cm/s to resolve arterial inflow. B, Placement of the measurement ROIs to measure flow properties in the superior sagittal sinus (red circle) and the straight sinus (green circle) with the corresponding measurement points in 1 R-R interval.

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    Fig 2.

    Example of the flow measurements (carotid arteries) of 1 patient showing no difference before and after LP (left). On the venous measurements of the SSS (right), a change in flow can be observed.

Tables

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    Table 1:

    Results of flow measurements, RI, and PI in the intracranial vasculature of n = 20 patients and n = 20 controlsa

    VesselParameterPatientsControlsPre-/Post-LP (P Value)Pre-LP/Controls (P Value)Post-LP/Controls (P Value)
    Pre-LPPost-LP
    SSSRI0.33 (±0.08)0.26 (±0.13)0.35 (±0.10).09.21<.04
    PI0.39 (±0.12)0.31 (±0.16)0.43 (±0.18).09.48<.04
    Flow (mL/min)454 (±133)457 (±85)526 (±119).86.08<.05
    IJVFlow (mL/min)663 (±195)564 (±216)653 (±199)<.01.88.20
    • ↵a A full list of results is presented in Tables 2 and 3. Data in columns 3–5 are mean values.

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    Table 2:

    Results of flow measurements, RI, and PI in the intracranial vasculature of n = 20 patients and n = 20 controlsa

    VesselPatientsControls
    Pre-LPPost-LP
    ICA
        Flow (mL/min)971 (±222)969 (±199)827 (±218)
        RI0.67 (±0.09)0.63 (±0.08)0.69 (±0.09)
        PI1.16 (±0.25)1.05 (±0.20)1.23 (±0.31)
    BA
        Flow (mL/min)219 (±87)236 (±90)316 (±109)
        RI0.66 (±0.10)0.50 (±0.63)0.62 (±0.10)
        PI1.20 (±0.32)0.96 (±0.57)0.99 (±0.20)
    Total arterial inflow (ICA+BA)
        Flow (mL/min)1189 (±235)1206 (±241)1143 (±261)
    SSS
        Flow (mL/min)454 (±133)457 (±85)526 (±119)
        RI0.33 (±0.08)0.26 (±0.13)0.35 (±0.10)
        PI0.39 (±0.12)0.31 (±0.16)0.43 (±0.18)
    SS
        Flow (mL/min)138 (±30)151 (±68)143 (±33)
        RI0.30 (±0.06)0.30 (±0.20)0.31 (±0.08)
        PI0.36 (±0.09)0.35 (±0.24)0.37 (±0.12)
    IJV
        Flow (mL/min)663 (±195)564 (±216)653 (±199)
        RI0.47 (±0.14)0.29 (±0.64)0.60 (±0.24)
        PI0.64 (±0.28)0.48 (±0.48)0.96 (±0.59)
    • ↵a Data are mean values of patients and volunteers.

    • View popup
    Table 3:

    Corresponding P values for Table 2

    VesselPre-/Post-LP (P Value)Pre-LP/Controls (P Value)Post-LP/Controls (P Value)
    ICA
        Flow (mL/min).98.05.04
        RI.20.66.04
        PI.17.50.04
    BA
        Flow (mL/min).21<.01.02
        RI.29.16.43
        PI.30.21.82
    Total arterial inflow (ICA+BA)
        Flow (mL/min).73.57.44
    SSS
        Flow (mL/min).86.08.05
        RI.09.21.04
        PI.09.48.04
    SS
        Flow (mL/min).46.59.65
        RI.91.73.78
        PI.90.79.78
    IJV
        Flow (mL/min)<.01.88.20
        RI.25.04.05
        PI.16.04<.01
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American Journal of Neuroradiology: 39 (4)
American Journal of Neuroradiology
Vol. 39, Issue 4
1 Apr 2018
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Cite this article
J. Juhász, T. Lindner, C. Riedel, N.G. Margraf, O. Jansen, A. Rohr
Quantitative Phase-Contrast MR Angiography to Measure Hemodynamic Changes in Idiopathic Intracranial Hypertension
American Journal of Neuroradiology Apr 2018, 39 (4) 682-686; DOI: 10.3174/ajnr.A5571

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Quantitative Phase-Contrast MR Angiography to Measure Hemodynamic Changes in Idiopathic Intracranial Hypertension
J. Juhász, T. Lindner, C. Riedel, N.G. Margraf, O. Jansen, A. Rohr
American Journal of Neuroradiology Apr 2018, 39 (4) 682-686; DOI: 10.3174/ajnr.A5571
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