β-Hydroxybutyrate Detection with Proton MR Spectroscopy in Children with Drug-Resistant Epilepsy on the Ketogenic Diet

References

1. 1.↵
   2. Wheless JW

   . History of the ketogenic diet. Epilepsia 2008;49(Suppl 8):3–5 doi:10.1111/j.1528-1167.2008.01821.x pmid:19049574

   CrossRefPubMed
2. 2.↵
   2. Brodie MJ

   . Antiepileptic drug therapy the story so far. Seizure 2010;19:650–55 doi:10.1016/j.seizure.2010.10.027 pmid:21075011

   CrossRefPubMedWeb of Science
3. 3.↵
   2. Kim JA,
   3. Yoon JR,
   4. Lee EJ, et al

   . Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy. Epilepsia 2016;57:51–58 doi:10.1111/epi.13256 pmid:26662710

   CrossRefPubMed
4. 4.↵
   2. Pan JW,
   3. Rothman TL,
   4. Behar KL, et al

   . Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis. J Cereb Blood Flow Metab 2000;20:1502–07 doi:10.1097/00004647-200010000-00012 pmid:11043913

   CrossRefPubMedWeb of Science
5. 5.↵
   2. Pan JW,
   3. Telang FW,
   4. Lee JH, et al

   . Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J Neurochem 2001;79:539–44 pmid:11701757

   CrossRefPubMedWeb of Science
6. 6.↵
   2. Owen OE,
   3. Morgan AP,
   4. Kemp HG, et al

   . Brain metabolism during fasting. J Clin Invest 1967;46:1589–95 doi:10.1172/JCI105650 pmid:6061736

   CrossRefPubMedWeb of Science
7. 7.↵
   2. Bough KJ,
   3. Rho JM

   . Anticonvulsant mechanisms of the ketogenic diet. Epilepsia 2007;48:43–58 pmid:17241207

   PubMed
8. 8.↵
   2. van Delft R,
   3. Lambrechts D,
   4. Verschuure P, et al

   . Blood beta-hydroxybutyrate correlates better with seizure reduction due to ketogenic diet than do ketones in the urine. Seizure 2010;19:36–39 doi:10.1016/j.seizure.2009.10.009 pmid:19962324

   CrossRefPubMedWeb of Science
9. 9.↵
   2. Novotny EJ,
   3. Rothman DL

   . Observation of cerebral ketone bodies by proton nuclear magnetic resonance spectroscopy [abstract]. Ann Neurol 1996;40:285 doi:10.1002/ana.410400232

   CrossRef
10. 10.↵
    2. Cecil KM,
    3. Mulkey SB,
    4. Ou X, et al

    . Brain ketones detected by proton magnetic resonance spectroscopy in an infant with Ohtahara syndrome treated with ketogenic diet. Pediatr Radiol 2015;45:133–37 doi:10.1007/s00247-014-3032-y pmid:24907925

    CrossRefPubMed
11. 11.↵
    2. Provencher SW

    . Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672–79 doi:10.1002/mrm.1910300604 pmid:8139448

    CrossRefPubMedWeb of Science
12. 12.↵
    2. Schubert F,
    3. Mekle R,
    4. Ittermann B, et al

    . Ketone bodies and glucose in human brain during ketogenic diet and fasting. In: Proceedings of the Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Imaging, Toronto, Ontario, Canada. May 30–June 5, 2015
13. 13.↵
    2. Kreis R,
    3. Ross BD

    . Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: detection with proton MR spectroscopy. Radiology 1992;184:123–30 doi:10.1148/radiology.184.1.1319074 pmid:1319074

    CrossRefPubMedWeb of Science
14. 14.↵
    2. Wootton-Gorges SL,
    3. Buonocore MH,
    4. Kuppermann N, et al

    . Detection of cerebral {beta}-hydroxybutyrate, acetoacetate, and lactate on proton MR spectroscopy in children with diabetic ketoacidosis. AJNR Am J Neuroradiol 2005;26:1286–91 pmid:15891198

    Abstract/FREE Full Text
15. 15.↵
    2. Plecko B,
    3. Stoeckler-Ipsiroglu S,
    4. Schober E, et al

    . Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. Pediatr Res 2002;52:301–06 pmid:12149510

    CrossRefPubMed
16. 16.↵
    2. Seymour KJ,
    3. Bluml S,
    4. Sutherling J, et al

    . Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet. MAGMA 1999;8:33–42 pmid:10383091

    PubMed
17. 17.↵
    2. Artzi M,
    3. Liberman G,
    4. Vaisman N, et al

    . Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors: 1H-MRS study. J Neurooncol 2017;132:267–75 doi:10.1007/s11060-016-2364-x pmid:28074323

    CrossRefPubMed
18. 18.↵
    2. Glaser N,
    3. Ngo C,
    4. Anderson S, et al

    . Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism. Diabetes 2012;61:1831–37 doi:10.2337/db11-1286 pmid:22498698

    Abstract/FREE Full Text
19. 19.↵
    2. Yudkoff M,
    3. Daikhin Y,
    4. Nissim I, et al

    . Brain amino acid metabolism and ketosis. J Neurosci Res 2001;66:272–81 doi:10.1002/jnr.1221 pmid:11592124

    CrossRefPubMed
20. 20.↵
    2. Scheenen TW,
    3. Klomp DW,
    4. Wijnen JP, et al

    . Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses. Magn Reson Med 2008;59:1–6 doi:10.1002/mrm.21302 pmid:17969076

    CrossRefPubMed
21. 21.
    2. Berg AT,
    3. Berkovic SF,
    4. Brodie MJ, et al

    . Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 2010;51:676–85 doi:10.1111/j.1528-1167.2010.02522.x pmid:20196795

    CrossRefPubMedWeb of Science
22. 22.
    2. Scheffer IE,
    3. Berkovic S,
    4. Capovilla G, et al

    . ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58:512–21 doi:10.1111/epi.13709 pmid:28276062

    CrossRefPubMed
23. 23.
    2. Bernier FP,
    3. Boneh A,
    4. Dennett X, et al

    . Diagnostic criteria for respiratory chain disorders in adults and children. Neurology 2002;59:1406–11 doi:10.1212/01.WNL.0000033795.17156.00 pmid:12427892

    Abstract/FREE Full Text