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Research ArticlePediatric Neuroimaging
Open Access

Quantitative Assessment of Normal Fetal Brain Myelination Using Fast Macromolecular Proton Fraction Mapping

V.L. Yarnykh, I.Y. Prihod'ko, A.A. Savelov and A.M. Korostyshevskaya
American Journal of Neuroradiology July 2018, 39 (7) 1341-1348; DOI: https://doi.org/10.3174/ajnr.A5668
V.L. Yarnykh
aFrom the Department of Radiology (V.L.Y.), University of Washington, Seattle, Washington
bResearch Institute of Biology and Biophysics (V.L.Y.), Tomsk State University, Tomsk, Russian Federation
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I.Y. Prihod'ko
cInstitute “International Tomography Center” of the Siberian Branch of the Russian Academy of Sciences (I.Y.P., A.A.S., A.M.K.), Novosibirsk, Russian Federation.
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A.A. Savelov
cInstitute “International Tomography Center” of the Siberian Branch of the Russian Academy of Sciences (I.Y.P., A.A.S., A.M.K.), Novosibirsk, Russian Federation.
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A.M. Korostyshevskaya
cInstitute “International Tomography Center” of the Siberian Branch of the Russian Academy of Sciences (I.Y.P., A.A.S., A.M.K.), Novosibirsk, Russian Federation.
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References

  1. 1.↵
    1. Minkowski A
    1. Yakovlev PI,
    2. Lecours AR
    . The myelogenetic cycles of regional maturation of the brain. In: Minkowski A, ed. Regional Development of the Brain in Early Life. Oxford: Blackwell; 1967:3–70
  2. 2.↵
    1. Kinney HC,
    2. Brody BA,
    3. Kloman AS, et al
    . Sequence of central nervous system myelination in human infancy, II: patterns of myelination in autopsied infants. J Neuropathol Exp Neurol 1988;47:217–34 doi:10.1097/00005072-198805000-00003 pmid:3367155
    CrossRefPubMed
  3. 3.↵
    1. Rees S,
    2. Inder T
    . Fetal and neonatal origins of altered brain development. Early Hum Dev 2005;81:753–61 doi:10.1016/j.earlhumdev.2005.07.004 pmid:16107304
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Yarnykh VL
    . Fast macromolecular proton fraction mapping from a single off-resonance magnetization transfer measurement. Magn Reson Med 2012;68:166–78 doi:10.1002/mrm.23224 pmid:22190042
    CrossRefPubMed
  5. 5.↵
    1. Yarnykh VL
    . Time-efficient, high-resolution, whole brain three-dimensional macromolecular proton fraction mapping. Magn Reson Med 2016;75:2100–06 doi:10.1002/mrm.25811 pmid:26102097
    CrossRefPubMed
  6. 6.↵
    1. Underhill HR,
    2. Rostomily RC,
    3. Mikheev AM, et al
    . Fast bound pool fraction imaging of the in vivo rat brain: association with myelin content and validation in the C6 glioma model. Neuroimage 2011;54:2052–65 doi:10.1016/j.neuroimage.2010.10.065 pmid:21029782
    CrossRefPubMed
  7. 7.↵
    1. Samsonov A,
    2. Alexander AL,
    3. Mossahebi P, et al
    . Quantitative MR imaging of two-pool magnetization transfer model parameters in myelin mutant shaking pup. Neuroimage 2012;62:1390–98 doi:10.1016/j.neuroimage.2012.05.077 pmid:22664569
    CrossRefPubMed
  8. 8.↵
    1. Thiessen JD,
    2. Zhang Y,
    3. Zhang H, et al
    . Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination. NMR Biomed 2013;26:1562–81 doi:10.1002/nbm.2992 pmid:23943390
    CrossRefPubMed
  9. 9.↵
    1. Janve VA,
    2. Zu Z,
    3. Yao SY, et al
    . The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions. Neuroimage 2013;74:298–305 doi:10.1016/j.neuroimage.2013.02.034 pmid:23481461
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Khodanovich MY,
    2. Sorokina IV,
    3. Glazacheva VY, et al
    . Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model. Sci Rep 2017;7:46686 doi:10.1038/srep46686 pmid:28436460
    CrossRefPubMed
  11. 11.↵
    1. Yarnykh VL,
    2. Bowen JD,
    3. Samsonov A, et al
    . Fast whole-brain three-dimensional macromolecular proton fraction mapping in multiple sclerosis. Radiology 2015;274:210–20 doi:10.1148/radiol.14140528 pmid:25208343
    CrossRefPubMed
  12. 12.↵
    1. Petrie EC,
    2. Cross DJ,
    3. Yarnykh VL, et al
    . Neuroimaging, behavioral, and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan war veterans. J Neurotrauma 2014;31:425–36 doi:10.1089/neu.2013.2952 pmid:24102309
    CrossRefPubMed
  13. 13.↵
    1. Yarnykh VL,
    2. Tartaglione EV,
    3. Ioannou GN
    . Fast macromolecular proton fraction mapping of the human liver in vivo for quantitative assessment of hepatic fibrosis. NMR Biomed 2015;28:1716–25 doi:10.1002/nbm.3437 pmid:26503401
    CrossRefPubMed
  14. 14.↵
    1. Naumova AV,
    2. Akulov AE,
    3. Khodanovich MY, et al
    . High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields. Neuroimage 2017;147:985–93 doi:10.1016/j.neuroimage.2016.09.036 pmid:27646128
    CrossRefPubMed
  15. 15.↵
    1. Yarnykh VL,
    2. Yuan C
    . Cross-relaxation imaging reveals detailed anatomy of white matter fiber tracts in the human brain. Neuroimage 2004;23:409–24 doi:10.1016/j.neuroimage.2004.04.029 pmid:15325389
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Gudbjartsson H,
    2. Patz S
    . The Rician distribution of noisy MRI data. Magn Reson Med 1995;34:910–14 doi:10.1002/mrm.1910340618 pmid:8598820
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Constantinides CD,
    2. Atalar E,
    3. McVeigh ER
    . Signal-to-noise measurements in magnitude images from NMR phased arrays. Magn Reson Med 1997;38:852–57 doi:10.1002/mrm.1910380524 pmid:9358462
    CrossRefPubMed
  18. 18.↵
    The Association of Electrical Equipment and Medical Imaging Manufacturers. Characterization of phased array coils for diagnostic magnetic resonance images. NEMA Standards Publication MS 9-2008. Arlington: National Electrical Manufacturers Association; 2008:9–15. http://www.nema.org/Standards/Pages/Characterization-of-Phased-Array-Coils-for-Diagnostic-Magnetic-Resonance-Images.aspx. Accessed March 15, 2018
  19. 19.↵
    1. Thayyil S,
    2. De Vita E,
    3. Sebire NJ, et al
    . Post-mortem cerebral magnetic resonance imaging T1 and T2 in fetuses, newborns and infants. Eur J Radiol 2012;81:e232–38 doi:10.1016/j.ejrad.2011.01.105 pmid:21349673
    CrossRefPubMed
  20. 20.↵
    1. Blazejewska AI,
    2. Seshamani S,
    3. McKown SK, et al
    . 3D in utero quantification of T2* relaxation times in human fetal brain tissues for age optimized structural and functional MRI. Magn Reson Med 2017;78:909–16 doi:10.1002/mrm.26471 pmid:27699879
    CrossRefPubMed
  21. 21.↵
    1. Righini A,
    2. Bianchini E,
    3. Parazzini C, et al
    . Apparent diffusion coefficient determination in normal fetal brain: a prenatal MR imaging study. AJNR Am J Neuroradiol 2003;24:799–804 pmid:12748074
    Abstract/FREE Full Text
  22. 22.↵
    1. Schneider JF,
    2. Confort-Gouny S,
    3. Le Fur Y, et al
    . Diffusion-weighted imaging in normal fetal brain maturation. Eur Radiol 2007;17:2422–29 doi:10.1007/s00330-007-0634-x pmid:17404738
    CrossRefPubMed
  23. 23.↵
    1. Gilles FH
    . Myelination in the neonatal brain. Hum Pathol 1976;7:244–48 doi:10.1016/S0046-8177(76)80035-4 pmid:57917
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Tanaka S,
    2. Mito T,
    3. Takashima S
    . Progress of myelination in the human fetal spinal nerve roots, spinal cord and brainstem with myelin basic protein immunohistochemistry. Early Hum Dev 1995;41:49–59 doi:10.1016/0378-3782(94)01608-R pmid:7540130
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Hasegawa M,
    2. Houdou S,
    3. Mito T, et al
    . Development of myelination in the human fetal and infant cerebrum: a myelin basic protein immunohistochemical study. Brain Dev 1992;14:1–6 doi:10.1016/S0387-7604(12)80271-3 pmid:1375444
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Girard N,
    2. Raybaud C,
    3. Poncet M
    . In vivo MR study of brain maturation in normal fetuses. AJNR Am J Neuroradiol 1995;16:407–13 pmid:7726092
    Abstract/FREE Full Text
  27. 27.↵
    1. Wang Z,
    2. Chen J,
    3. Qin Z, et al
    . The research of myelinization of normal fetal brain with magnetic resonance imaging. Chin Med J (Engl) 1998;111:71–74 pmid:10322659
    PubMed
  28. 28.↵
    1. Chung HW,
    2. Chen CY,
    3. Zimmerman RA, et al
    . T2-Weighted fast MR imaging with true FISP versus HASTE: comparative efficacy in the evaluation of normal fetal brain maturation. AJR Am J Roentgenol 2000;175:1375–80 doi:10.2214/ajr.175.5.1751375 pmid:11044047
    CrossRefPubMed
  29. 29.↵
    1. Abe S,
    2. Takagi K,
    3. Yamamoto T, et al
    . Semiquantitative assessment of myelination using magnetic resonance imaging in normal fetal brains. Prenat Diagn 2004;24:352–57 doi:10.1002/pd.873 pmid:15164408
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Brisse H,
    2. Fallet C,
    3. Sebag G, et al
    . Supratentorial parenchyma in the developing fetal brain: in vitro MR study with histologic comparison. AJNR Am J Neuroradiol 1997;18:1491–97 pmid:9296190
    Abstract
  31. 31.↵
    1. Kostović I,
    2. Judas M,
    3. Rados M, et al
    . Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cereb Cortex 2002;12:536–44 doi:10.1093/cercor/12.5.536 pmid:11950771
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Anstrom JA,
    2. Thore CR,
    3. Moody DM, et al
    . Morphometric assessment of collagen accumulation in germinal matrix vessels of premature human neonates. Neuropathol Appl Neurobiol 2005;31:181–90 doi:10.1111/j.1365-2990.2004.00626.x pmid:15771711
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Yarnykh VL
    . Optimal radiofrequency and gradient spoiling for improved accuracy of T1 and B1 measurements using fast steady-state techniques. Magn Reson Med 2010;63:1610–26 doi:10.1002/mrm.22394 pmid:20512865
    CrossRefPubMed
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V.L. Yarnykh, I.Y. Prihod'ko, A.A. Savelov, A.M. Korostyshevskaya
Quantitative Assessment of Normal Fetal Brain Myelination Using Fast Macromolecular Proton Fraction Mapping
American Journal of Neuroradiology Jul 2018, 39 (7) 1341-1348; DOI: 10.3174/ajnr.A5668

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Quantitative Assessment of Normal Fetal Brain Myelination Using Fast Macromolecular Proton Fraction Mapping
V.L. Yarnykh, I.Y. Prihod'ko, A.A. Savelov, A.M. Korostyshevskaya
American Journal of Neuroradiology Jul 2018, 39 (7) 1341-1348; DOI: 10.3174/ajnr.A5668
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