Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePatient Safety

Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents

H. Kang, M. Hii, M. Le, R. Tam, A. Riddehough, A. Traboulsee, S. Kolind, M.S. Freedman and D.K.B. Li
American Journal of Neuroradiology September 2018, 39 (9) 1597-1603; DOI: https://doi.org/10.3174/ajnr.A5751
H. Kang
aFrom the Department of Radiology (H.K., M.L., R.T., S.K., D.K.B.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. Kang
M. Hii
bUniversity of British Columbia MS/MRI Research Group (M.H., R.T., A.R., A.T., S.K., D.K.B.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Hii
M. Le
aFrom the Department of Radiology (H.K., M.L., R.T., S.K., D.K.B.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Le
R. Tam
aFrom the Department of Radiology (H.K., M.L., R.T., S.K., D.K.B.L.)
bUniversity of British Columbia MS/MRI Research Group (M.H., R.T., A.R., A.T., S.K., D.K.B.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Tam
A. Riddehough
bUniversity of British Columbia MS/MRI Research Group (M.H., R.T., A.R., A.T., S.K., D.K.B.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Riddehough
A. Traboulsee
bUniversity of British Columbia MS/MRI Research Group (M.H., R.T., A.R., A.T., S.K., D.K.B.L.)
cDepartment of Medicine and Division of Neurology (A.T., S.K., D.K.B.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Traboulsee
S. Kolind
aFrom the Department of Radiology (H.K., M.L., R.T., S.K., D.K.B.L.)
bUniversity of British Columbia MS/MRI Research Group (M.H., R.T., A.R., A.T., S.K., D.K.B.L.)
cDepartment of Medicine and Division of Neurology (A.T., S.K., D.K.B.L.)
dDepartment of Physics and Astronomy (S.K.), University of British Columbia, Vancouver, British Columbia, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Kolind
M.S. Freedman
eDepartment of Medicine and Division of Neurology (M.S.F.), University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.S. Freedman
D.K.B. Li
aFrom the Department of Radiology (H.K., M.L., R.T., S.K., D.K.B.L.)
bUniversity of British Columbia MS/MRI Research Group (M.H., R.T., A.R., A.T., S.K., D.K.B.L.)
cDepartment of Medicine and Division of Neurology (A.T., S.K., D.K.B.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.K.B. Li
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Hao D,
    2. Ai T,
    3. Goerner F, et al
    . MRI contrast agents: basic chemistry and safety. J Magn Reson Imaging 2012;36:1060–71 doi:10.1002/jmri.23725 pmid:23090917
    CrossRefPubMed
  2. 2.↵
    1. Frenzel T,
    2. Lengsfeld P,
    3. Schirmer H, et al
    . Stability of gadolinium-based magnetic resonance imaging contrast agents in human serum at 37°C. Invest Radiol 2008;43:817–28 doi:10.1097/RLI.0b013e3181852171 pmid:19002053
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Tweedle MF,
    2. Wedeking P,
    3. Kumar K
    . Biodistribution of radiolabeled, formulated gadopentetate, gadoteridol, gadoterate, and gadodiamide in mice and rats. Invest Radiol 1995;30:372–80 doi:10.1097/00004424-199506000-00008 pmid:7490190
    CrossRefPubMed
  4. 4.↵
    1. Kanda T,
    2. Ishii K,
    3. Kawaguchi H, et al
    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270:834–41 doi:10.1148/radiol.13131669 pmid:24475844
    CrossRefPubMed
  5. 5.↵
    1. Murata N,
    2. Gonzalez-Cuyar LF,
    3. Murata K, et al
    . Macrocyclic and other non–group 1 gadolinium contrast agents deposit low levels of gadolinium in brain and bone tissue: preliminary results from 9 patients with normal renal function. Invest Radiol 2016;51:447–53 doi:10.1097/RLI.0000000000000252 pmid:26863577
    CrossRefPubMed
  6. 6.↵
    1. McDonald RJ,
    2. McDonald JS,
    3. Kallmes DF, et al
    . Intracranial gadolinium deposition after contrast-enhanced MR imaging. Radiology 2015;275:772–82 doi:10.1148/radiol.15150025 pmid:25742194
    CrossRefPubMed
  7. 7.↵
    1. Kanda T,
    2. Osawa M,
    3. Oba H, et al
    . High signal intensity in dentate nucleus on unenhanced T1-weighted MR images: association with linear versus macrocyclic gadolinium chelate administration. Radiology 2015;275:803–09 doi:10.1148/radiol.14140364 pmid:25633504
    CrossRefPubMed
  8. 8.↵
    1. Quattrocchi CC,
    2. Mallio CA,
    3. Errante Y, et al
    . Gadodiamide and dentate nucleus T1 hyperintensity in patients with meningioma evaluated by multiple follow-up contrast-enhanced magnetic resonance examinations with no systemic interval therapy. Invest Radiol 2015;50:470–72 doi:10.1097/RLI.0000000000000154 pmid:25756685
    CrossRefPubMed
  9. 9.↵
    1. Errante Y,
    2. Cirimele V,
    3. Mallio CA, et al
    . Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation. Invest Radiol 2014;49:685–90 doi:10.1097/RLI.0000000000000072 pmid:24872007
    CrossRefPubMed
  10. 10.↵
    1. Radbruch A,
    2. Weberling LD,
    3. Kieslich PJ, et al
    . Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 2015;275:783–91 doi:10.1148/radiol.2015150337 pmid:25848905
    CrossRefPubMed
  11. 11.↵
    1. Cao Y,
    2. Huang DQ,
    3. Shih G, et al
    . Signal change in the dentate nucleus on T1-weighted MR images after multiple administrations of gadopentetate dimeglumine versus gadobutrol. AJR Am J Roentgenol 2016;206:414–19 doi:10.2214/AJR.15.15327 pmid:26700156
    CrossRefPubMed
  12. 12.↵
    1. Weberling LD,
    2. Kieslich PJ,
    3. Kickingereder P, et al
    . Increased signal intensity in the dentate nucleus on unenhanced T1-weighted images after gadobenate dimeglumine administration. Invest Radiol 2015;50:743–48 doi:10.1097/RLI.0000000000000206 pmid:26352749
    CrossRefPubMed
  13. 13.↵
    1. Radbruch A,
    2. Weberling LD,
    3. Kieslich PJ, et al
    . Intraindividual analysis of signal intensity changes in the dentate nucleus after consecutive serial applications of linear and macrocyclic gadolinium-based contrast agents. Invest Radiol 2016;51:683–90 doi:10.1097/RLI.0000000000000308 pmid:27495187
    CrossRefPubMed
  14. 14.↵
    1. Ramalho J,
    2. Castillo M,
    3. AlObaidy M, et al
    . High signal intensity in globus pallidus and dentate nucleus on unenhanced T1-weighted MR images: evaluation of two linear gadolinium-based contrast agents. Radiology 2015;276:836–44 doi:10.1148/radiol.2015150872 pmid:26079490
    CrossRefPubMed
  15. 15.↵
    1. Freedman MS,
    2. Bar-Or A,
    3. Oger J, et al
    ; MAESTRO-01 Investigators. A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS. Neurology 2011;77:1551–60 doi:10.1212/WNL.0b013e318233b240 pmid:21975206
    CrossRefPubMed
  16. 16.↵
    1. Adin ME,
    2. Kleinberg L,
    3. Vaidya D, et al
    . Hyperintense dentate nuclei on T1-weighted MRI: relation to repeat gadolinium administration. AJNR Am J Neuroradiol 2015;36:1859–65 doi:10.3174/ajnr.A4378 pmid:26294649
    Abstract/FREE Full Text
  17. 17.↵
    1. Flood TF,
    2. Stence NV,
    3. Maloney JA, et al
    . Pediatric brain: repeated exposure to linear gadolinium-based contrast material is associated with increased signal intensity at unenhanced T1-weighted MR imaging. Radiology 2017;282:222–28 doi:10.1148/radiol.2016160356 pmid:27467467
    CrossRefPubMed
  18. 18.↵
    1. Hu HH,
    2. Pokorney A,
    3. Towbin RB, et al
    . Increased signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evidence in children undergoing multiple gadolinium MRI exams. Pediatr Radiol 2016;46:1590–98 doi:10.1007/s00247-016-3646-3 pmid:27282825
    CrossRefPubMed
  19. 19.↵
    1. Ramalho J,
    2. Semelka RC,
    3. Ramalho M, et al
    . Gadolinium-based contrast agent accumulation and toxicity: an update. AJNR Am J Neuroradiol 2016;37:1192–98 doi:10.3174/ajnr.A4615 pmid:26659341
    Abstract/FREE Full Text
  20. 20.↵
    1. Zhang Y,
    2. Cao Y,
    3. Shih GL, et al
    . Extent of signal hyperintensity on unenhanced T1-weighted brain MR images after more than 35 administrations of linear gadolinium-based contrast agents. Radiology 2017;282:516–25 doi:10.1148/radiol.2016152864 pmid:27513848
    CrossRefPubMed
  21. 21.↵
    1. Radbruch A
    . Are some agents less likely to deposit gadolinium in the brain? Magn Reson Imaging 2016;34:1351–54 doi:10.1016/j.mri.2016.09.001 pmid:27629022
    CrossRefPubMed
  22. 22.↵
    1. Jost G,
    2. Frenzel T,
    3. Lohrke J, et al
    . Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue. Eur Radiol 2017;27:2877–85 doi:10.1007/s00330-016-4654-2 pmid:27832312
    CrossRefPubMed
  23. 23.↵
    1. Öner AY,
    2. Barutcu B,
    3. Aykol Ş, et al
    . Intrathecal contrast-enhanced magnetic resonance imaging-related brain signal changes: residual gadolinium deposition? Invest Radiol 2017;52:195–97 doi:10.1097/RLI.0000000000000327 pmid:27755154
    CrossRefPubMed
  24. 24.↵
    1. Frenzel T,
    2. Apte C,
    3. Jost G, et al
    . Quantification and assessment of the chemical form of residual gadolinium in the brain after repeated administration of gadolinium-based contrast agents: comparative study in rats. Invest Radiol 2017;52:396–404 doi:10.1097/RLI.0000000000000352 pmid:28125438
    CrossRefPubMed
  25. 25.↵
    1. Gulani V,
    2. Calamante F,
    3. Shellock FG, et al
    ; International Society for Magnetic Resonance in Medicine. Chelated or dechelated gadolinium deposition: authors' reply. Lancet Neurol 2017;16:955–56 doi:10.1016/S1474-4422(17)30365-4 pmid:29165254
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 39 (9)
American Journal of Neuroradiology
Vol. 39, Issue 9
1 Sep 2018
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
H. Kang, M. Hii, M. Le, R. Tam, A. Riddehough, A. Traboulsee, S. Kolind, M.S. Freedman, D.K.B. Li
Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents
American Journal of Neuroradiology Sep 2018, 39 (9) 1597-1603; DOI: 10.3174/ajnr.A5751

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents
H. Kang, M. Hii, M. Le, R. Tam, A. Riddehough, A. Traboulsee, S. Kolind, M.S. Freedman, D.K.B. Li
American Journal of Neuroradiology Sep 2018, 39 (9) 1597-1603; DOI: 10.3174/ajnr.A5751
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Accuracy of Noncontrast T2 SPACE in Active MS Cord Lesion Detection
  • Gadolinium Deposition: A Study Review
  • Comparison of Unenhanced and Gadolinium-Enhanced Imaging in Multiple Sclerosis: Is Contrast Needed for Routine Follow-Up MRI?
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

Patient Safety

  • Safety of Intrathecal Gadobutrol in Various Doses
  • Impact of Kidney Function on CNS Gadolinium Deposition in Patients Receiving Repeated Doses of Gadobutrol
  • Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting
Show more Patient Safety

Adult Brain

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire