Vessel Wall Enhancement in Unruptured Intracranial Aneurysms: An Indicator for Higher Risk of Rupture? High-Resolution MR Imaging and Correlated Histologic Findings

References

1. 1.↵
   2. Wiebers DO,
   3. Whisnant JP,
   4. Huston J 3rd., et al

   ; International Study of Unruptured Intracranial Aneurysms Investigators. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003;362:103–10 pmid:12867109

   CrossRefPubMedWeb of Science
2. 2.↵
   2. Vlak MH,
   3. Algra A,
   4. Brandenburg R, et al

   . Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol 2011;10:626–36 doi:10.1016/S1474-4422(11)70109-0 pmid:21641282

   CrossRefPubMedWeb of Science
3. 3.↵
   2. Nieuwkamp DJ,
   3. Setz LE,
   4. Algra A, et al

   . Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis. Lancet Neurol 2009;8:635–42 doi:10.1016/S1474-4422(09)70126-7 pmid:19501022

   CrossRefPubMedWeb of Science
4. 4.↵
   2. Edjlali M,
   3. Gentric JC,
   4. Régent-Rodriguez C, et al

   . Does aneurysmal wall enhancement on vessel wall MRI help to distinguish stable from unstable intracranial aneurysms? Stroke 2014;45:3704–06 doi:10.1161/STROKEAHA.114.006626 pmid:25325912

   Abstract/FREE Full Text
5. 5.↵
   2. Hu P,
   3. Yang Q,
   4. Wang DD, et al

   . Wall enhancement on high-resolution magnetic resonance imaging may predict an unsteady state of an intracranial saccular aneurysm. Neuroradiology 2016;58:979–85 doi:10.1007/s00234-016-1729-3 pmid:27438805

   CrossRefPubMed
6. 6.↵
   2. Nagahata S,
   3. Nagahata M,
   4. Obara M, et al

   . Wall enhancement of the intracranial aneurysms revealed by magnetic resonance vessel wall imaging using three-dimensional turbo spin-echo sequence with motion-sensitized driven-equilibrium: a sign of ruptured aneurysm? Clin Neuroradiol 2016;26:277–83 doi:10.1007/s00062-014-0353-z pmid:25332151

   CrossRefPubMed
7. 7.↵
   2. Matouk CC,
   3. Mandell DM,
   4. Günel M, et al

   . Vessel wall magnetic resonance imaging identifies the site of rupture in patients with multiple intracranial aneurysms: proof of principle. Neurosurgery 2013;72:492–96; discussion 496 doi:10.1227/NEU.0b013e31827d1012 pmid:23151622

   CrossRefPubMed
8. 8.↵
   2. Ollikainen E,
   3. Tulamo R,
   4. Frösen J, et al

   . Mast cells, neovascularization, and microhemorrhages are associated with saccular intracranial artery aneurysm wall remodeling. J Neuropathol Exp Neurol 2014;73:855–64 doi:10.1097/NEN.0000000000000105 pmid:25101705

   CrossRefPubMed
9. 9.↵
   2. Hoh BL,
   3. Hosaka K,
   4. Downes DP, et al

   . Stromal cell-derived factor-1 promoted angiogenesis and inflammatory cell infiltration in aneurysm walls. J Neurosurg 2014;120:73–86 doi:10.3171/2013.9.JNS122074 pmid:24160472

   CrossRefPubMed
10. 10.↵
    2. Gounis MJ,
    3. Vedantham S,
    4. Weaver JP, et al

    . Myeloperoxidase in human intracranial aneurysms: preliminary evidence. Stroke 2014;45:1474–77 doi:10.1161/STROKEAHA.114.004956 pmid:24713525

    Abstract/FREE Full Text
11. 11.↵
    2. Gounis MJ,
    3. van der Marel K,
    4. Marosfoi M, et al

    . Imaging inflammation in cerebrovascular disease. Stroke 2015;46:2991–97 doi:10.1161/STROKEAHA.115.008229 pmid:26351362

    FREE Full Text
12. 12.↵
    2. Portanova A,
    3. Hakakian N,
    4. Mikulis DJ, et al

    . Intracranial vasa vasorum: insights and implications for imaging. Radiology 2013;267:667–79 doi:10.1148/radiol.13112310 pmid:23704290

    CrossRefPubMed
13. 13.↵
    2. Maiellaro K,
    3. Taylor WR

    . The role of the adventitia in vascular inflammation. Cardiovasc Res 2007;75:640–48 doi:10.1016/j.cardiores.2007.06.023 pmid:17662969

    CrossRefPubMedWeb of Science
14. 14.↵
    2. Nakatomi H,
    3. Segawa H,
    4. Kurata A, et al

    . Clinicopathological study of intracranial fusiform and dolichoectatic aneurysms: insight on the mechanism of growth. Stroke 2000;31:896–900 doi:10.1161/01.STR.31.4.896 pmid:10753995

    Abstract/FREE Full Text
15. 15.↵
    2. Warneke VS,
    3. Behrens HM,
    4. Haag J, et al

    . Prognostic and putative predictive biomarkers of gastric cancer for personalized medicine. Diagn Mol Pathol 2013;22:127–37 doi:10.1097/PDM.0b013e318284188e pmid:23846438

    CrossRefPubMed
16. 16.↵
    2. Greving JP,
    3. Wermer MJ,
    4. Brown RD Jr., et al

    . Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol 2014;13:59–66 doi:10.1016/S1474-4422(13)70263-1 pmid:24290159

    CrossRefPubMed
17. 17.↵
    2. Etminan N,
    3. Brown RD Jr.,
    4. Beseoglu K, et al

    . The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus. Neurology 2015;85:881–89 doi:10.1212/WNL.0000000000001891 pmid:26276380

    CrossRefPubMed
18. 18.↵
    2. Dhar S,
    3. Tremmel M,
    4. Mocco J, et al

    . Morphology parameters for intracranial aneurysm rupture risk assessment. Neurosurgery 2008;63:185–96; discussion 196–97 doi:10.1227/01.NEU.0000316847.64140.81 pmid:18797347

    CrossRefPubMedWeb of Science
19. 19.↵
    2. Rahman M,
    3. Smietana J,
    4. Hauck E, et al

    . Size ratio correlates with intracranial aneurysm rupture status: a prospective study. Stroke 2010;41:916–20 doi:10.1161/STROKEAHA.109.574244 pmid:20378866

    Abstract/FREE Full Text
20. 20.↵
    2. Xiang J,
    3. Natarajan SK,
    4. Tremmel M, et al

    . Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke 2011;42:144–52 doi:10.1161/STROKEAHA.110.592923 pmid:21106956

    CrossRefPubMed
21. 21.↵
    2. Cebral JR,
    3. Mut F,
    4. Weir J, et al

    . Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. AJNR Am J Neuroradiol 2011;32:145–51 doi:10.3174/ajnr.A2419 pmid:21127144

    Abstract/FREE Full Text
22. 22.↵
    2. Chien A,
    3. Sayre J,
    4. Viñuela F

    . Comparative morphological analysis of the geometry of ruptured and unruptured aneurysms. Neurosurgery 2011;69:349–56 doi:10.1227/NEU.0b013e31821661c3 pmid:21415785

    CrossRefPubMedWeb of Science
23. 23.↵
    2. Baharoglu MI,
    3. Lauric A,
    4. Gao BL, et al

    . Identification of a dichotomy in morphological predictors of rupture status between sidewall- and bifurcation-type intracranial aneurysms. J Neurosurg 2012;116:871–81 doi:10.3171/2011.11.JNS11311 pmid:22242668

    CrossRefPubMedWeb of Science
24. 24.↵
    2. Lin N,
    3. Ho A,
    4. Gross BA, et al

    . Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysms. J Neurosurg 2012;117:913–19 doi:10.3171/2012.7.JNS111766 pmid:22957531

    CrossRefPubMedWeb of Science
25. 25.↵
    2. Cai W,
    3. Shi D,
    4. Gong J, et al

    . Are morphologic parameters actually correlated with the rupture status of anterior communicating artery aneurysms? World Neurosurg 2015;84:1278–83 doi:10.1016/j.wneu.2015.05.060 pmid:26054869

    CrossRefPubMed
26. 26.↵
    2. Kang H,
    3. Ji W,
    4. Qian Z, et al

    . Aneurysm characteristics associated with the rupture risk of intracranial aneurysms: a self-controlled study. PLoS One 2015;10:e0142330 doi:10.1371/journal.pone.0142330 pmid:26540158

    CrossRefPubMed
27. 27.↵
    2. Ho AL,
    3. Lin N,
    4. Frerichs KU, et al

    . Intrinsic, transitional, and extrinsic morphological factors associated with rupture of intracranial aneurysms. Neurosurgery 2015;77:433–41; discussion 441–42 doi:10.1227/NEU.0000000000000835 pmid:26075307

    CrossRefPubMed
28. 28.↵
    2. Zheng Y,
    3. Xu F,
    4. Ren J, et al

    . Assessment of intracranial aneurysm rupture based on morphology parameters and anatomical locations. J Neurointerv Surg 2016 Jan 11. [Epub ahead of print]. doi:10.1136/neurintsurg-2015-012112 pmid:26863105

    Abstract/FREE Full Text
29. 29.↵
    2. Cebral J,
    3. Ollikainen E,
    4. Chung BJ, et al

    . Flow conditions in the intracranial aneurysm lumen are associated with inflammation and degenerative changes of the aneurysm wall. AJNR Am J Neuroradiol 2017;38:119–26 doi:10.3174/ajnr.A4951 pmid:27686488

    Abstract/FREE Full Text