Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

G. Pontillo, S. Cocozza, R. Lanzillo, C. Russo, M.D. Stasi, C. Paolella, E.A. Vola, C. Criscuolo, P. Borrelli, G. Palma, E. Tedeschi, V.B. Morra, A. Elefante and A. Brunetti
American Journal of Neuroradiology January 2019, 40 (1) 99-106; DOI: https://doi.org/10.3174/ajnr.A5915
G. Pontillo
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
dInstitute of Biostructure and Bioimaging (G.P.), National Research Council, Naples, Italy.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Pontillo
S. Cocozza
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Cocozza
R. Lanzillo
bNeurosciences and Reproductive and Odontostomatological Sciences (R.L., C.C., V.B.M.), University of Naples “Federico II”, Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Lanzillo
C. Russo
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Russo
M.D. Stasi
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.D. Stasi
C. Paolella
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Paolella
E.A. Vola
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E.A. Vola
C. Criscuolo
bNeurosciences and Reproductive and Odontostomatological Sciences (R.L., C.C., V.B.M.), University of Naples “Federico II”, Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Criscuolo
P. Borrelli
cIRCCS SDN (P.B.), Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Borrelli
G. Palma
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Palma
E. Tedeschi
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Tedeschi
V.B. Morra
bNeurosciences and Reproductive and Odontostomatological Sciences (R.L., C.C., V.B.M.), University of Naples “Federico II”, Naples, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V.B. Morra
A. Elefante
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Elefante
A. Brunetti
aFrom the Departments of Advanced Biomedical Sciences (G.P., S.C., C.R., M.D.S., C.P., E.A.V., E.T., A.E., A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Brunetti
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Pirko I,
    2. Lucchinetti CF,
    3. Sriram S, et al
    . Gray matter involvement in multiple sclerosis. Neurology 2007;68:634–42 doi:10.1212/01.wnl.0000250267.85698.7a pmid:17325269
    Abstract/FREE Full Text
  2. 2.↵
    1. Eshaghi A,
    2. Marinescu RV,
    3. Young AL, et al
    . Progression of regional grey matter atrophy in multiple sclerosis. Brain 2018;141:1665–77 doi:10.1093/brain/awy088 pmid:29741648
    CrossRefPubMed
  3. 3.↵
    1. Zivadinov R,
    2. Havrdová E,
    3. Bergsland N, et al
    . Thalamic atrophy is associated with development of clinically definite multiple sclerosis. Radiology 2013;268:831–41 doi:10.1148/radiol.13122424 pmid:23613615
    CrossRefPubMed
  4. 4.↵
    1. Eshaghi A,
    2. Prados F,
    3. Brownlee WJ, et al
    ; MAGNIMS study group. Deep gray matter volume loss drives disability worsening in multiple sclerosis. Ann Neurol 2018;83:210–22 doi:10.1002/ana.25145 pmid:29331092
    CrossRefPubMed
  5. 5.↵
    1. Schoonheim MM,
    2. Hulst HE,
    3. Brandt RB, et al
    . Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis. Neurology 2015;84:776–83 doi:10.1212/WNL.0000000000001285 pmid:25616483
    CrossRefPubMed
  6. 6.↵
    1. Hasan KM,
    2. Halphen C,
    3. Kamali A, et al
    . Caudate nuclei volume, diffusion tensor metrics, and T(2) relaxation in healthy adults and relapsing-remitting multiple sclerosis patients: implications for understanding gray matter degeneration. J Magn Reson Imaging 2009;29:70–77 doi:10.1002/jmri.21648 pmid:19097116
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Hannoun S,
    2. Durand-Dubief F,
    3. Confavreux C, et al
    . Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis. AJNR Am J Neuroradiol 2012;33:1363–68 doi:10.3174/ajnr.A2983 pmid:22383236
    Abstract/FREE Full Text
  8. 8.↵
    1. Cavallari M,
    2. Ceccarelli A,
    3. Wang GY, et al
    . Microstructural changes in the striatum and their impact on motor and neuropsychological performance in patients with multiple sclerosis. PLoS One 2014;9:e101199 doi:10.1371/journal.pone.0101199 pmid:25047083
    CrossRefPubMed
  9. 9.↵
    1. Tovar-Moll F,
    2. Evangelou IE,
    3. Chiu AW, et al
    . Thalamic involvement and its impact on clinical disability in patients with multiple sclerosis: a diffusion tensor imaging study at 3T. AJNR Am J Neuroradiol 2009;30:1380–86 doi:10.3174/ajnr.A1564 pmid:19369608
    Abstract/FREE Full Text
  10. 10.↵
    1. Debernard L,
    2. Melzer TR,
    3. Van Stockum S, et al
    . Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2014;85:544–51 doi:10.1136/jnnp-2013-305612 pmid:24039024
    Abstract/FREE Full Text
  11. 11.↵
    1. Inglese M,
    2. Park SJ,
    3. Johnson G, et al
    . Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Arch Neurol 2007;64:196–202 doi:10.1001/archneur.64.2.196 pmid:17296835
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Doche E,
    2. Lecocq A,
    3. Maarouf A, et al
    . Hypoperfusion of the thalamus is associated with disability in relapsing remitting multiple sclerosis. J Neuroradiol 2017;44:158–64 doi:10.1016/j.neurad.2016.10.001 pmid:27865557
    CrossRefPubMed
  13. 13.↵
    1. Lapointe E,
    2. Li DK,
    3. Traboulsee AL, et al
    . What have we learned from perfusion MRI in multiple sclerosis? AJNR Am J Neuroradiol 2018;39:994–1000 doi:10.3174/ajnr.A5504 pmid:29301779
    Abstract/FREE Full Text
  14. 14.↵
    1. Zivadinov R,
    2. Tavazzi E,
    3. Bergsland N, et al
    . Brain iron at quantitative MRI is associated with disability in multiple sclerosis. Radiology 2018;289:487–96 doi:10.1148/radiol.2018180136 pmid:30015589
    CrossRefPubMed
  15. 15.↵
    1. Hagemeier J,
    2. Zivadinov R,
    3. Dwyer MG, et al
    . Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain. Neuroimage Clin 2018;18:1007–16 doi:10.1016/j.nicl.2017.04.008 pmid:29868452
    CrossRefPubMed
  16. 16.↵
    1. Burgetova A,
    2. Dusek P,
    3. Vaneckova M, et al
    . Thalamic iron differentiates primary-progressive and relapsing-remitting multiple sclerosis. AJNR Am J Neuroradiol 2017;38:1079–86 doi:10.3174/ajnr.A5166 pmid:28450431
    Abstract/FREE Full Text
  17. 17.↵
    1. Schweser F,
    2. Raffaini Duarte Martins AL,
    3. Hagemeier J, et al
    . Mapping of thalamic magnetic susceptibility in multiple sclerosis indicates decreasing iron with disease duration: a proposed mechanistic relationship between inflammation and oligodendrocyte vitality. Neuroimage 2018;167:438–52 doi:10.1016/j.neuroimage.2017.10.063 pmid:29097315
    CrossRefPubMed
  18. 18.↵
    1. Haider L,
    2. Simeonidou C,
    3. Steinberger G, et al
    . Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron. J Neurol Neurosurg Psychiatry 2014;85:1386–95 doi:10.1136/jnnp-2014-307712 pmid:24899728
    Abstract/FREE Full Text
  19. 19.↵
    1. Vercellino M,
    2. Masera S,
    3. Lorenzatti M, et al
    . Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol Exp Neurol 2009;68:489–502 doi:10.1097/NEN.0b013e3181a19a5a pmid:19525897
    CrossRefPubMed
  20. 20.↵
    1. Lublin FD,
    2. Reingold SC,
    3. Cohen JA, et al
    . Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology 2014;83:278–86 doi:10.1212/WNL.0000000000000560 pmid:24871874
    CrossRefPubMed
  21. 21.↵
    1. Cocozza S,
    2. Canna A,
    3. Lanzillo R, et al
    . Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study. Br J Radiol 2016 Jun 27:20160321. [Epub ahead of print] doi:10.1259/bjr.20160321 pmid:27282838
    CrossRefPubMed
  22. 22.↵
    1. Tedeschi E,
    2. Palma G,
    3. Canna A, et al
    . In vivo dentate nucleus MRI relaxometry correlates with previous administration of gadolinium-based contrast agents. Eur Radiol 2016;26:4577–84 doi:10.1007/s00330-016-4245-2 pmid:26905870
    CrossRefPubMed
  23. 23.↵
    1. Polman CH,
    2. Reingold SC,
    3. Banwell B, et al
    . Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292–302 doi:10.1002/ana.22366 pmid:21387374
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Palma G,
    2. Tedeschi E,
    3. Borrelli P, et al
    . A novel multiparametric approach to 3D quantitative MRI of the brain. PLoS One 2015;10:e0134963 doi:10.1371/journal.pone.0134963 pmid:26284778
    CrossRefPubMed
  25. 25.↵
    1. Borrelli P,
    2. Palma G,
    3. Tedeschi E, et al
    . Improving signal-to-noise ratio in susceptibility weighted imaging: a novel multicomponent non-local approach. PLoS One 2015;10:e0126835 doi:10.1371/journal.pone.0126835 pmid:26030293
    CrossRefPubMed
  26. 26.↵
    1. Palma G,
    2. Comerci M,
    3. Alfano B, et al
    . 3D non-local means denoising via multi-GPU. In Proceedings of the 2013 Federated Conference on Computer Science and Information Systems, Kraków, Poland; September 8–11, 2013:495–98
  27. 27.↵
    1. Mahad DH,
    2. Trapp BD,
    3. Lassmann H
    . Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol 2015;14:183–93 doi:10.1016/S1474-4422(14)70256-X pmid:25772897
    CrossRefPubMed
  28. 28.↵
    1. Inglese M,
    2. Adhya S,
    3. Johnson G, et al
    . Perfusion magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis. J Cereb Blood Flow Metab 2008;28:164–71 doi:10.1038/sj.jcbfm.9600504 pmid:17473851
    CrossRefPubMed
  29. 29.↵
    1. Papadaki EZ,
    2. Mastorodemos VC,
    3. Amanakis EZ, et al
    . White matter and deep gray matter hemodynamic changes in multiple sclerosis patients with clinically isolated syndrome. Magn Reson Med 2012;68:1932–42 doi:10.1002/mrm.24194 pmid:22367604
    CrossRefPubMed
  30. 30.↵
    1. Debernard L,
    2. Melzer TR,
    3. Alla S, et al
    . Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Res 2015;234:352–61 doi:10.1016/j.pscychresns.2015.10.004 pmid:26602610
    CrossRefPubMed
  31. 31.↵
    1. Mühlau M,
    2. Buck D,
    3. Förschler A, et al
    . White-matter lesions drive deep gray-matter atrophy in early multiple sclerosis: support from structural MRI. Mult Scler 2013;19:1485–92 doi:10.1177/1352458513478673 pmid:23462349
    CrossRefPubMed
  32. 32.↵
    1. Hametner S,
    2. Wimmer I,
    3. Haider L, et al
    . Iron and neurodegeneration in the multiple sclerosis brain. Ann Neurol 2013;74:848–61 doi:10.1002/ana.23974 pmid:23868451
    CrossRefPubMed
  33. 33.↵
    1. Minagar A,
    2. Barnett MH,
    3. Benedict RH, et al
    . The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects. Neurology 2013;80:210–19 doi:10.1212/WNL.0b013e31827b910b pmid:23296131
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 40 (1)
American Journal of Neuroradiology
Vol. 40, Issue 1
1 Jan 2019
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
G. Pontillo, S. Cocozza, R. Lanzillo, C. Russo, M.D. Stasi, C. Paolella, E.A. Vola, C. Criscuolo, P. Borrelli, G. Palma, E. Tedeschi, V.B. Morra, A. Elefante, A. Brunetti
Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study
American Journal of Neuroradiology Jan 2019, 40 (1) 99-106; DOI: 10.3174/ajnr.A5915

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study
G. Pontillo, S. Cocozza, R. Lanzillo, C. Russo, M.D. Stasi, C. Paolella, E.A. Vola, C. Criscuolo, P. Borrelli, G. Palma, E. Tedeschi, V.B. Morra, A. Elefante, A. Brunetti
American Journal of Neuroradiology Jan 2019, 40 (1) 99-106; DOI: 10.3174/ajnr.A5915
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Leveraging Hand-Crafted Radiomics on Multicenter FLAIR MRI for Predicting Disability Progression in People with Multiple Sclerosis
  • Quantitative MRI in Multiple Sclerosis: From Theory to Application
  • Lesion Volume in Relapsing Multiple Sclerosis is Associated with Perivascular Space Enlargement at the Level of the Basal Ganglia
  • A Combined Radiomics and Machine Learning Approach to Overcome the Clinicoradiologic Paradox in Multiple Sclerosis
  • Tissue damage detected by quantitative gradient echo MRI correlates with clinical progression in non-relapsing progressive MS
  • Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis
  • The Development of Subcortical Gray Matter Atrophy in Multiple Sclerosis: One Size Does Not Fit All
  • What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire