Imaging of Patients with Suspected Large-Vessel Occlusion at Primary Stroke Centers: Available Modalities and a Suggested Approach

References

1. 1.↵
   2. Messé SR,
   3. Khatri P,
   4. Reeves MJ, et al

   . Why are acute ischemic stroke patients not receiving IV tPA? Results from a national registry. Neurology 2016;87:1565–74 doi:10.1212/WNL.0000000000003198 pmid:27629092

   CrossRefPubMed
2. 2.↵
   2. Goyal M,
   3. Menon BK,
   4. van Zwam WH, et al

   ; HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387:1723–31 doi:10.1016/S0140-6736(16)00163-X pmid:26898852

   CrossRefPubMed
3. 3.↵
   2. Saver JL,
   3. Goyal M,
   4. van der Lugt A, et al

   ; HERMES collaborators. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA 2016;316:1279–88 doi:10.1001/jama.2016.13647 pmid:27673305

   CrossRefPubMed
4. 4.↵
   2. Albers GW,
   3. Marks MP,
   4. Kemp S, et al

   ; DEFUSE 3 Investigators. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 2018;378:708–18 doi:10.1056/NEJMoa1713973 pmid:29364767

   CrossRefPubMed
5. 5.↵
   2. Nogueira RG,
   3. Jadhav AP,
   4. Haussen DC, et al

   ; DAWN Trial Investigators. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 2018;378:11–21 doi:10.1056/NEJMoa1706442 pmid:29129157

   CrossRefPubMed
6. 6.↵
   2. Llanes JN,
   3. Kidwell CS,
   4. Starkman S, et al

   . The Los Angeles Motor Scale (LAMS): a new measure to characterize stroke severity in the field. Prehosp Emerg Care 2004;8:46–50 doi:10.1080/312703002806 pmid:14691787

   CrossRefPubMed
7. 7.↵
   2. Amy Y,
   3. Zerna C,
   4. Assis Z, et al

   . Multiphase CT angiography increases detection of anterior circulation intracranial occlusion. Neurology 2016;87:609–16 doi:10.1212/WNL.0000000000002951 pmid:27385749

   Abstract/FREE Full Text
8. 8.↵
   2. Menon BK,
   3. d'Esterre CD,
   4. Qazi EM, et al

   . Multiphase CT angiography: a new tool for the imaging triage of patients with acute ischemic stroke. Radiology 2015;275:510–20 doi:10.1148/radiol.15142256 pmid:25633505

   CrossRefPubMed
9. 9.↵
   2. Tan BY,
   3. Wan-Yee K,
   4. Paliwal P, et al

   . Good intracranial collaterals trump poor ASPECTS (Alberta Stroke Program Early CT Score) for intravenous thrombolysis in anterior circulation acute ischemic stroke. Stroke 2016;47:2292–98 doi:10.1161/STROKEAHA.116.013879 pmid:27491731

   Abstract/FREE Full Text
10. 10.↵
    2. Thomalla G,
    3. Simonsen CZ,
    4. Boutitie F, et al

    ; WAKE-UP Investigators. MRI-guided thrombolysis for stroke with unknown time of onset. N Engl J Med 2018;379:611–22 doi:10.1056/NEJMoa1804355 pmid:29766770

    CrossRefPubMed
11. 11.↵
    2. Jovin TG

    . MRI-guided intravenous alteplase for stroke: still stuck in time. N Engl J Med 2018;379:682–83 doi:10.1056/NEJMe1805796 pmid:29766752

    CrossRefPubMed
12. 12.↵
    2. Goyal M,
    3. Menon BK,
    4. Wilson AT, et al

    . Primary to comprehensive stroke center transfers: appropriateness, not futility. Int J Stroke 2018;13:550–53 doi:10.1177/1747493018764072 pmid:29508654

    CrossRefPubMed
13. 13.↵
    2. Liebeskind DS,
    3. Bracard S,
    4. Guillemin F, et al

    . eTICI reperfusion: defining success in endovascular stroke therapy. J Neurointerv Surg 2018:neurintsurg-2018-014127
14. 14.↵
    2. Mishra SM,
    3. Dykeman J,
    4. Sajobi TT, et al

    . Early reperfusion rates with IV tPA are determined by CTA clot characteristics. AJNR Am J Neuroradiol 2014;35:2265–72 doi:10.3174/ajnr.A4048 pmid:25059699

    Abstract/FREE Full Text
15. 15.↵
    2. Menon BK,
    3. Al-Ajlan FS,
    4. Najm M, et al

    ; INTERRSeCT Study Investigators. Association of clinical, imaging, and thrombus characteristics with recanalization of visible intracranial occlusion in patients with acute ischemic stroke. JAMA 2018;320:1017–26 doi:10.1001/jama.2018.12498 pmid:30208455

    CrossRefPubMed
16. 16.↵
    2. Menon BK,
    3. Campbell BC,
    4. Levi C, et al

    . Role of imaging in current acute ischemic stroke workflow for endovascular therapy. Stroke 2015;46:1453–61 doi:10.1161/STROKEAHA.115.009160 pmid:25944319

    Abstract/FREE Full Text
17. 17.↵
    2. Sun CH,
    3. Connelly K,
    4. Nogueira RG, et al

    . ASPECTS decay during inter-facility transfer predicts patient outcomes in endovascular reperfusion for ischemic stroke: a unique assessment of dynamic physiologic change over time. J Neurointerv Surg 2015;7:22–26 doi:10.1136/neurintsurg-2013-011048 pmid:24443414

    Abstract/FREE Full Text
18. 18.↵
    2. Sun CH,
    3. Nogueira RG,
    4. Glenn BA, et al

    . “Picture to puncture”: a novel time metric to enhance outcomes in patients transferred for endovascular reperfusion in acute ischemic stroke. Circulation 2013;127:1139–48 doi:10.1161/CIRCULATIONAHA.112.000506 pmid:23393011

    Abstract/FREE Full Text
19. 19.↵
    2. McTaggart RA,
    3. Yaghi S,
    4. Cutting SM, et al

    . Association of a primary stroke center protocol for suspected stroke by large-vessel occlusion with efficiency of care and patient outcomes. JAMA Neurol 2017;74:793–800 doi:10.1001/jamaneurol.2017.0477 pmid:28492918

    CrossRefPubMed
20. 20.
    2. Kharitonova T,
    3. Thorén M,
    4. Ahmed N, et al

    ; SITS investigators. Disappearing hyperdense middle cerebral artery sign in ischaemic stroke patients treated with intravenous thrombolysis: clinical course and prognostic significance. J Neurol Neurosurg Psychiatry 2009;80:273–78 doi:10.1136/jnnp.2008.150185 pmid:18931005

    Abstract/FREE Full Text
21. 21.↵
    2. Bal S,
    3. Bhatia R,
    4. Menon BK, et al

    . Time dependence of reliability of noncontrast computed tomography in comparison to computed tomography angiography source image in acute ischemic stroke. Int J Stroke 2015;10:55–60 doi:10.1111/j.1747-4949.2012.00859.x pmid:22974504

    CrossRefPubMed
22. 22.
    2. Hopyan J,
    3. Ciarallo A,
    4. Dowlatshahi D, et al

    . Certainty of stroke diagnosis: incremental benefit with CT perfusion over noncontrast CT and CT angiography. Radiology 2010;255:142–53 doi:10.1148/radiol.09091021 pmid:20308452

    CrossRefPubMedWeb of Science
23. 23.
    2. Austein F,
    3. Riedel C,
    4. Kerby T, et al

    . Comparison of perfusion CT software to predict the final infarct volume after thrombectomy. Stroke 2016;47:2311–17 doi:10.1161/STROKEAHA.116.013147 pmid:27507864

    Abstract/FREE Full Text
24. 24.
    2. Bivard A,
    3. Kleinig T,
    4. Miteff F, et al

    . Ischemic core thresholds change with time to reperfusion: a case control study. Ann Neurol 2017;82:995–1003 doi:10.1002/ana.25109 pmid:29205466

    CrossRefPubMed
25. 25.
    2. Goyal M,
    3. Menon BK,
    4. Derdeyn CP

    . Perfusion imaging in acute ischemic stroke: let us improve the science before changing clinical practice. Radiology 2013;266:16–21 doi:10.1148/radiol.12112134 pmid:23264523

    CrossRefPubMedWeb of Science
26. 26.↵
    2. Berkhemer OA,
    3. Fransen PS,
    4. Beumer D, et al

    . A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015;372:11–20 doi:10.1056/NEJMoa1411587 pmid:25517348

    CrossRefPubMedWeb of Science
27. 27.↵
    2. Bracard S,
    3. Ducrocq X,
    4. Mas JL, et al

    ; THRACE investigators, Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial. Lancet Neurol 2016;15:1138–47 doi:10.1016/S1474-4422(16)30177-6 pmid:27567239

    CrossRefPubMed
28. 28.↵
    2. Powers WJ,
    3. Rabinstein AA,
    4. Ackerson T, et al

    ; American Heart Association Stroke Council. 2018 Guidelines for the Early Management of Patients with Acute Ischemic Stroke: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke 2018;49:e46–110 doi:10.1161/STR.0000000000000158 pmid:29367334

    Abstract/FREE Full Text
29. 29.↵
    2. Tsivgoulis G,
    3. Katsanos AH,
    4. Schellinger PD, et al

    . Successful reperfusion with intravenous thrombolysis preceding mechanical thrombectomy in large-vessel occlusions. Stroke 2018;49:232–35 doi:10.1161/STROKEAHA.117.019261 pmid:29212743

    Abstract/FREE Full Text
30. 30.↵
    2. Boulouis G,
    3. Lauer A,
    4. Siddiqui AK, et al

    . Clinical imaging factors associated with infarct progression in patients with ischemic stroke during transfer for mechanical thrombectomy. JAMA Neurol 2017;74:1361–67 doi:10.1001/jamaneurol.2017.2149 pmid:28973081

    CrossRefPubMed
31. 31.↵
    2. Mokin M,
    3. Gupta R,
    4. Guerrero WR, et al

    . ASPECTS decay during inter-facility transfer in patients with large vessel occlusion strokes. J Neurointerv Surg 2017;9:442–44 doi:10.1136/neurintsurg-2016-012331 pmid:27106593

    Abstract/FREE Full Text
32. 32.↵
    2. Goyal M,
    3. Demchuk AM,
    4. Menon BK, et al

    ; ESCAPE Trial Investigators. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 2015;372:1019–30 doi:10.1056/NEJMoa1414905 pmid:25671798

    CrossRefPubMed
33. 33.↵
    2. Lee EJ,
    3. Kim YH,
    4. Kim N, et al

    . Deep into the brain: artificial intelligence in stroke imaging. J Stroke 2017;19:277 doi:10.5853/jos.2017.02054 pmid:29037014

    CrossRefPubMed
34. 34.↵
    2. Nagel S,
    3. Sinha D,
    4. Day D, et al

    . e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patients. Int J Stroke 2017;12:615–22 doi:10.1177/1747493016681020 pmid:27899743

    CrossRefPubMed
35. 35.↵
    2. Kellner CP,
    3. Sauvageau E,
    4. Snyder KV, et al

    . The VITAL study and overall pooled analysis with the VIPS non-invasive stroke detection device. J Neurointerv Surg 2018;10:1079–84 doi:10.1136/neurintsurg-2017-013690 pmid:29511114

    Abstract/FREE Full Text