Longitudinal White Matter Changes following Carbon Monoxide Poisoning: A 9-Month Follow-Up Voxelwise Diffusional Kurtosis Imaging Study

M.-C. Chou; J.-Y. Li; P.-H. Lai

doi:10.3174/ajnr.A5979

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Fig 1.
The FLAIR images of 3 patients acquired at 1 month after CO intoxication. A, A male patient (32 years of age) who had only GP lesions did not develop DNS. B, A female patient (37 years of age) who had only diffuse WMLs developed DNS. C, A male patient (49 years of age) who had both diffuse WMLs and GP lesions developed DNS.
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Fig 2.
The voxelwise comparison of FA values between patients with WMLs and healthy controls. The yellow-to-red areas indicate regions with values that were significantly decreased in the patients, and the color bar on the right-hand side indicates T values.
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Fig 3.
The voxelwise comparison of MK values between patients with WMLs and healthy controls. The yellow-to-red areas indicate regions with values that were significantly decreased in the patients, and the color bar on the right-hand side indicates T values.

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Table 1:

Demographic characteristics of enrolled subjects

	Patients with CO Intoxication		Controls
	WML	Non-WML	Controls
Sex (M/F)	6:5	5:8	10:11
Age (mean) (yr)	44.5 ± 15.3	35.7 ± 9.3	41.0 ± 11.9
Duration of coma (mean) (hr)	44.7 ± 48.8^{^a}	11.7 ± 17.6^{^a}	NA
Carboxyhemoglobin (mean) (%)	22.3 ± 20.9	31.37 ± 15.1	NA
Sessions of HBOT (mean)	11.2 ± 10.1	8.9 ± 2.5	NA
DNS (No.) (M/F)	5 (3:2)	0	NA
GP involvement (No.) (M/F)	8 (5:3)	4 (2:2)	NA

Note:—HBOT indicates hyperbaric oxygen therapy; NA, not applicable.
↵a P < .05.

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Table 2:

The ROC analysis of diffusional indices for CP, IC, and FWM in differentiating patients with DNS from those without DNS at 1 week after CO intoxication^{^a}

Brain Regions (MNI Coordinates) (mm)	DNS	Non-DNS	Controls	AUC (DNS vs non-DNS)
Lt. CP (−14, −14, −12)
FA (mean)	0.52 ± 0.03	0.56 ± 0.06	0.60 ± 0.05	.7394
Rt. IC (17, −10, 0)
AD (mean)	1.38 ± 0.08	1.49 ± 0.14	1.49 ± 0.08	.7394
AK (mean)	0.87 ± 0.05	0.74 ± 0.08	0.80 ± 0.03	.9156^{^b}
Lt. IC (−17, −10, 0)
AD (mean)	1.38 ± 0.06	1.49 ± 0.13	1.48 ± 0.11	.7762
AK (mean)	0.89 ± 0.06	0.80 ± 0.08	0.81 ± 0.08	.7113
Rt. FWM (14, 31, −12)
AD (mean)	1.30 ± 0.03	1.18 ± 0.14	1.19 ± 0.14	.7436
AK (mean)	1.03 ± 0.04	0.86 ± 0.12	0.83 ± 0.09	.9057^{^b}
Lt. FWM (−14, 31, −12)
RD (mean)	0.78 ± 0.04	0.74 ± 0.07	0.62 ± 0.07	.7436
MD (mean)	0.94 ± 0.03	0.94 ± 0.05	0.90 ± 0.06	.7299
MK (mean)	0.98 ± 0.06	0.86 ± 0.07	0.89 ± 0.12	.8627^{^b}

Note:—AUC indicates area under the curve; ROC, receiver operating characteristic; Lt., left; Rt., right; MNI, Montreal Neurological Institute.
↵a The unit for AD, RD, and MD is 10⁻³ mm²/s.
↵b P < .05.