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Research ArticleAdult Brain
Open Access

Morphologic Features on MR Imaging Classify Multifocal Glioblastomas in Different Prognostic Groups

J. Pérez-Beteta, D. Molina-García, M. Villena, M.J. Rodríguez, C. Velásquez, J. Martino, B. Meléndez-Asensio, Á. Rodríguez de Lope, R. Morcillo, J.M. Sepúlveda, A. Hernández-Laín, A. Ramos, J.A. Barcia, P.C. Lara, D. Albillo, A. Revert, E. Arana and V.M. Pérez-García
American Journal of Neuroradiology April 2019, 40 (4) 634-640; DOI: https://doi.org/10.3174/ajnr.A6019
J. Pérez-Beteta
aFrom the Department of Mathematics (J.P.-B., D.M.-G., V.M.P.-G.), Mathematical Oncology Laboratory, Universidad de Castilla-La Mancha, Ciudad Real, Spain
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D. Molina-García
aFrom the Department of Mathematics (J.P.-B., D.M.-G., V.M.P.-G.), Mathematical Oncology Laboratory, Universidad de Castilla-La Mancha, Ciudad Real, Spain
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M. Villena
bDepartments of Neurosurgery (M.V.)
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M.J. Rodríguez
cRadiology (M.J.R.), Hospital General de Ciudad Real, Ciudad Real, Spain
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  • ORCID record for M.J. Rodríguez
C. Velásquez
dDepartment of Neurosurgery (J.M., C.V.), Hospital Universitario Marqués de Valdecilla and Fundación, Instituto de Investigación Marqués de Valdecilla, Santander, Spain
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J. Martino
dDepartment of Neurosurgery (J.M., C.V.), Hospital Universitario Marqués de Valdecilla and Fundación, Instituto de Investigación Marqués de Valdecilla, Santander, Spain
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B. Meléndez-Asensio
eDepartments of Molecular Biology (B.M.-A.)
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Á. Rodríguez de Lope
fNeurosurgery (Á.R.d.L.)
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R. Morcillo
gRadiology (R.M.), Hospital Virgen de la Salud, Toledo, Spain
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J.M. Sepúlveda
hDepartments of Neuro-Oncology (J.M.S.)
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A. Hernández-Laín
iPathology (A.H.-L.)
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A. Ramos
jRadiology (A. Ramos), Hospital Universitario 12 de Octubre, Madrid, Spain
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J.A. Barcia
kDepartment of Neurosurgery (J.A.B.), Hospital Clínico San Carlos, Madrid, Spain
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P.C. Lara
lDepartment of Radiation Oncology (P.C.L.), San Roque University Hospital/Universidad Fernando Pessoa Canarias, Gran Canaria, Spain
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D. Albillo
mDepartment of Radiology (D.A.), Hospital Universitario de Salamanca, Salamanca, Spain
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A. Revert
nDepartment of Radiology (A. Revert), Hospital de Manises, Valencia, Spain
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E. Arana
oDepartment of Radiology (E.A.), Fundación Instituto Valenciano de Oncología, Valencia, Spain.
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V.M. Pérez-García
aFrom the Department of Mathematics (J.P.-B., D.M.-G., V.M.P.-G.), Mathematical Oncology Laboratory, Universidad de Castilla-La Mancha, Ciudad Real, Spain
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REFERENCES

  1. 1.↵
    1. Gillies RJ,
    2. Kinahan PE,
    3. Hricak H
    . Radiomics: images are more than pictures, they are data. Radiology 2016;278:563–77 doi:10.1148/radiol.2015151169 pmid:26579733
    CrossRefPubMed
  2. 2.↵
    1. Ellingson BM
    . Radiogenomics and imaging phenotypes in glioblastoma: novel observations and correlation with molecular characteristics. Curr Neurol Neurosci Rep 2015;15:506 doi:10.1007/s11910-014-0506-0 pmid:25410316
    CrossRefPubMed
  3. 3.↵
    1. Wen PY,
    2. Macdonald DR,
    3. Reardon DA, et al
    . Updated response assessment criteria for high-grade gliomas: Response Assessment in Neuro-Oncology Working Group. J Clin Oncol 2010;28:1963–72 doi:10.1200/JCO.2009.26.3541 pmid:20231676
    Abstract/FREE Full Text
  4. 4.↵
    1. Narang S,
    2. Lehrer M,
    3. Yang D, et al
    . Radiomics in glioblastoma: current status, challenges and opportunities. Translational Cancer Research 2016;5:383–97 doi:10.21037/tcr.2016.06.31
    CrossRef
  5. 5.↵
    1. Abrol S,
    2. Kotrotsou A,
    3. Salem A
    . Radiomic phenotyping in brain cancer to unravel hidden information in medical images. Top Magn Reson Imaging 2017;26:43–53 doi:10.1097/RMR.0000000000000117 pmid:28079714
    CrossRefPubMed
  6. 6.↵
    1. Cui Y,
    2. Tha KK,
    3. Teresaka S, et al
    . Prognostic imaging biomarkers in glioblastoma: development and independent validation on the basis of multiregion and quantitative analysis of MR images. Radiology 2016;278:546–53 doi:10.1148/radiol.2015150358 pmid:26348233
    CrossRefPubMed
  7. 7.↵
    1. Pérez-Beteta J,
    2. Molina-García D,
    3. Ortiz-Alhambra JA, et al
    . Tumor surface regularity at MR imaging predicts survival and response to surgery in patients with glioblastoma. Radiology 2018; 288:218–55 doi:10.1148/radiol.201171051 pmid:29924716
    CrossRefPubMed
  8. 8.↵
    1. Rathore S,
    2. Akbari H,
    3. Rozycki M, et al
    . Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1. Sci Rep 2018;8:5087 doi:10.1038/s41598-018-22739-2 pmid:29572492
    CrossRefPubMed
  9. 9.↵
    1. Cui Y,
    2. Ren S,
    3. Tha KK, et al
    . Volume of high-risk intratumoral subregions at multi-parametric MR imaging predicts overall survival and complements molecular analysis of glioblastoma. Eur Radiol 2017;27:3583–92 doi:10.1007/s00330-017-4751-x pmid:28168370
    CrossRefPubMed
  10. 10.↵
    1. Kickingereder P,
    2. Burth S,
    3. Wick A, et al
    . Radiomic profiling of glioblastoma: identifying an imaging predictor of patient survival with improved performance over established clinical and radiologic risk models. Radiology 2016;280:880–89 doi:10.1148/radiol.2016160845 pmid:27326665
    CrossRefPubMed
  11. 11.↵
    1. Lao J,
    2. Chen Y,
    3. Li ZC, et al
    . A deep learning-based radiomics model for prediction of survival in glioblastoma multiforme. Sci Rep 2017;7:10353 doi:10.1038/s41598-017-10649-8 pmid:28871110
    CrossRefPubMed
  12. 12.↵
    1. Wangaryattawanich P,
    2. Hatami M,
    3. Wang J, et al
    . Multicenter imaging outcomes study of The Cancer Genome Atlas glioblastoma patient cohort: imaging predictors of overall and progression-free survival. Neuro Oncol 2015;17:1525–37 doi:10.1093/neuonc/nov117 pmid:26203066
    CrossRefPubMed
  13. 13.↵
    1. Ingrisch M,
    2. Schneider MJ,
    3. Nörenberg D, et al
    . Radiomic analysis reveals prognostic information in T1-weighted baseline magnetic resonance imaging in patients with glioblastoma. Invest Radiol 2017;52:360–66 doi:10.1097/RLI.0000000000000349 pmid:28079702
    CrossRefPubMed
  14. 14.↵
    1. Lasocki A,
    2. Gaillard F,
    3. Tacey M, et al
    . Multifocal and multicentric glioblastoma: improved characterisation with FLAIR imaging and prognostic implications. J Clin Neurosci 2016;31:92–98 doi:10.1016/j.jocn.2016.02.022 pmid:27343042
    CrossRefPubMed
  15. 15.↵
    1. Singh G,
    2. Mehrotra A,
    3. Sardhara J, et al
    . Multiple glioblastomas: are they different from their solitary counterparts? Asian J Neurosurg 2015;10:266–71 doi:10.4103/1793-5482.162685 pmid:26425153
    CrossRefPubMed
  16. 16.↵
    1. Showalter TN,
    2. Andrel J,
    3. Andrews DW, et al
    . Multifocal glioblastoma multiforme: prognostic factors and patterns of progression. Int J Radiat Oncol Biol Phys 2007;69:820–24 doi:10.1016/j.ijrobp.2007.03.045 pmid:17499453
    CrossRefPubMed
  17. 17.↵
    1. Di Carlo DT,
    2. Cagnazzo F,
    3. Benedetto N, et al
    . Multiple high-grade gliomas: epidemiology, management, and outcome: a systematic review and meta-analysis. Neurosurg Rev 2017 Nov 14. [Epub ahead of print] doi:10.1007/s10143-017-0928-7 pmid:29138949
    CrossRefPubMed
  18. 18.↵
    1. Patil CG,
    2. Yi A,
    3. Elramsisy A, et al
    . Prognosis of patients with multifocal glioblastoma: a case-control study. J Neurosurg 2012;117:705–11 doi:10.3171/2012.7.JNS12147 pmid:22920963
    CrossRefPubMed
  19. 19.↵
    1. Giannopoulos S,
    2. Kyritsis AP
    . Diagnosis and management of multifocal gliomas. Oncology 2010;79:306–12 doi:10.1159/000323492 pmid:21412017
    CrossRefPubMed
  20. 20.↵
    1. Paulsson AK,
    2. Holmes JA,
    3. Peiffer AM, et al
    . Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma. J Neurooncol 2014;119:429–35 doi:10.1007/s11060-014-1515-1 pmid:24990827
    CrossRefPubMed
  21. 21.↵
    1. Pérez-Beteta J,
    2. Martínez-González A,
    3. Molina D, et al
    . Glioblastoma: does the pretreatment geometry matter? A postcontrast T1 MRI-based study. Eur Radiol 2017;27:1096–104 doi:10.1007/s00330-016-4453-9 pmid:27329522
    CrossRefPubMed
  22. 22.↵
    1. Harrell FE Jr.,
    2. Califf R,
    3. Pryor D, et al
    . Evaluating the yield of medical tests. JAMA 1982;247:2543–46 doi:10.1001/jama.247.18.2543 pmid:7069920
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Hassaneen W,
    2. Levine NB,
    3. Suki D, et al
    . Multiple craniotomies in the management of multifocal and multicentric glioblastoma. J Neurosurg 2011;114:576–84 doi:10.3171/2010.6.JNS091326 pmid:20690813
    CrossRefPubMed
  24. 24.↵
    1. Pérez-García VM,
    2. Calvo GF,
    3. Belmonte-Beitia J, et al
    . Bright solitary waves in malignant gliomas. Phys Rev E Stat Nonlin Soft Matter Phys 2011;84:021921 doi:10.1103/PhysRevE.84.021921 pmid:21929033
    CrossRefPubMed
  25. 25.↵
    1. Grabowsky MM,
    2. Recinos PF,
    3. Nowacki AS, et al
    . Residual tumor volume versus extent of resection: predictors of survival after surgery for glioblastoma. J Neurosurg 2014;121:1115–23 doi:10.3171/2014.7.JNS132449 pmid:25192475
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Henker C,
    2. Kriesen T,
    3. Glass Ä, et al
    . Volumetric quantification of glioblastoma: experiences with different measurement techniques and impact on survival. J Neurooncol 2017;135:391–402 doi:10.1007/s11060-017-2587-5 pmid:28755324
    CrossRefPubMed
  27. 27.↵
    1. Pérez-Beteta J,
    2. Molina-García D,
    3. Martínez-González A, et al
    . Morphological MRI-based features provide pretreatment survival prediction in glioblastoma. Eur Radiol 2018 Oct 15. [Epub ahead of print] doi:10.1007/s00330-018-5758-7 pmid:30324390
    CrossRefPubMed
  28. 28.↵
    1. Prior FW,
    2. Clark K,
    3. Commean P, et al
    . TCIA: an information resource to enable open science. Conf Proc IEEE Eng Med Biol Soc 2013;2013:1282–85 doi:10.1109/EMBC.2013.6609742 pmid:24109929
    CrossRefPubMed
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J. Pérez-Beteta, D. Molina-García, M. Villena, M.J. Rodríguez, C. Velásquez, J. Martino, B. Meléndez-Asensio, Á. Rodríguez de Lope, R. Morcillo, J.M. Sepúlveda, A. Hernández-Laín, A. Ramos, J.A. Barcia, P.C. Lara, D. Albillo, A. Revert, E. Arana, V.M. Pérez-García
Morphologic Features on MR Imaging Classify Multifocal Glioblastomas in Different Prognostic Groups
American Journal of Neuroradiology Apr 2019, 40 (4) 634-640; DOI: 10.3174/ajnr.A6019

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Morphologic Features on MR Imaging Classify Multifocal Glioblastomas in Different Prognostic Groups
J. Pérez-Beteta, D. Molina-García, M. Villena, M.J. Rodríguez, C. Velásquez, J. Martino, B. Meléndez-Asensio, Á. Rodríguez de Lope, R. Morcillo, J.M. Sepúlveda, A. Hernández-Laín, A. Ramos, J.A. Barcia, P.C. Lara, D. Albillo, A. Revert, E. Arana, V.M. Pérez-García
American Journal of Neuroradiology Apr 2019, 40 (4) 634-640; DOI: 10.3174/ajnr.A6019
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