Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticlePediatrics

Brain MRI Findings in Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Challenges in Differentiation from Acute Disseminated Encephalomyelitis

E. Bulut, J. Karakaya, S. Salama, M. Levy, T.A.G.M. Huisman and I. Izbudak
American Journal of Neuroradiology April 2019, 40 (4) 726-731; DOI: https://doi.org/10.3174/ajnr.A6003
E. Bulut
aFrom the Departments of Radiology (E.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Bulut
J. Karakaya
bStatistics (J.K.), Hacettepe University Faculty of Medicine, Ankara, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Karakaya
S. Salama
cDepartment of Neurology and Psychiatry (S.S.), University of Alexandria, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Salama
M. Levy
dDepartment of Neurology (M.L.), Johns Hopkins School of Medicine, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Levy
T.A.G.M. Huisman
fEdward B. Singleton Chair of Radiology (T.A.G.M.H.), Texas Children's Hospital, Houston, Texas.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.A.G.M. Huisman
I. Izbudak
eSection of Pediatric Neuroradiology (I.I.), Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for I. Izbudak
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. Wingerchuk DM,
    2. Hogancamp WF,
    3. O'Brien PC, et al
    . The clinical course of neuromyelitis optica (Devic's syndrome). Neurology 1999;53:1107–14 doi:10.1212/WNL.53.5.1107 pmid:10496275
    Abstract/FREE Full Text
  2. 2.↵
    1. Wingerchuk DM,
    2. Lennon VA,
    3. Pittock SJ, et al
    . Revised diagnostic criteria for neuromyelitis optica. Neurology 2006;66:1485–89 doi:10.1212/01.wnl.0000216139.44259.74 pmid:16717206
    Abstract/FREE Full Text
  3. 3.↵
    1. Wingerchuk DM,
    2. Lennon VA,
    3. Lucchinetti CF, et al
    . The spectrum of neuromyelitis optica. Lancet Neurol 2007;6:805–15 doi:10.1016/S1474-4422(07)70216-8 pmid:17706564
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Wingerchuk DM,
    2. Banwell B,
    3. Bennett JL, et al
    ; International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015;85:177–89 doi:10.1212/WNL.0000000000001729 pmid:26092914
    CrossRefPubMed
  5. 5.↵
    1. Pittock SJ,
    2. Lennon VA,
    3. Krecke K, et al
    . Brain abnormalities in neuromyelitis optica. Arch Neurol 2006;63:390–96 doi:10.1001/archneur.63.3.390 pmid:16533966
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Pittock SJ,
    2. Weinshenker BG,
    3. Lucchinetti CF, et al
    . Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. Arch Neurol 2006;63:964–68 doi:10.1001/archneur.63.7.964 pmid:16831965
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Kim W,
    2. Park MS,
    3. Lee SH, et al
    . Characteristic brain magnetic resonance imaging abnormalities in central nervous system aquaporin-4 autoimmunity. Mult Scler 2010;16:1229–36 doi:10.1177/1352458510376640 pmid:20685766
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Kim HJ,
    2. Paul F,
    3. Lana-Peixoto MA, et al
    ; Guthy-Jackson Charitable Foundation NMO International Clinical Consortium & Biorepository. MRI characteristics of neuromyelitis optica spectrum disorder: an international update. Neurology 2015;84:1165–73 doi:10.1212/WNL.0000000000001367 pmid:25695963
    Abstract/FREE Full Text
  9. 9.↵
    1. Katz Sand I
    . Neuromyelitis optica spectrum disorders. Continuum (Minneap Minn) 2016;22:864–96 doi:10.1212/CON.0000000000000337 pmid:27261687
    CrossRefPubMed
  10. 10.↵
    1. Kim JE,
    2. Kim SM,
    3. Ahn SW, et al
    . Brain abnormalities in neuromyelitis optica. J Neurol Sci 2011;302:43–48 doi:10.1016/j.jns.2010.12.001 pmid:21236446
    CrossRefPubMed
  11. 11.↵
    1. Tenembaum S,
    2. Chitnis T,
    3. Nakashima I, et al
    . Neuromyelitis optica spectrum disorders in children and adolescents. Neurology 2016;87:S59–66 doi:10.1212/WNL.0000000000002824 pmid:27572863
    Abstract/FREE Full Text
  12. 12.↵
    1. McKeon A,
    2. Lennon VA,
    3. Lotze T, et al
    . CNS aquaporin-4 autoimmunity in children. Neurology 2008;71:93–100 doi:10.1212/01.wnl.0000314832.24682.c6 pmid:18509092
    Abstract/FREE Full Text
  13. 13.↵
    1. Absoud M,
    2. Lim MJ,
    3. Appleton R, et al
    . Paediatric neuromyelitis optica: clinical, MRI of the brain and prognostic features. J Neurol Neurosurg Psychiatry 2015;86:470–72 doi:10.1136/jnnp-2014-308550 pmid:25091363
    Abstract/FREE Full Text
  14. 14.↵
    1. Collongues N,
    2. Marignier R,
    3. Zéphir H, et al
    . Long-term follow-up of neuromyelitis optica with a pediatric onset. Neurology 2010;75:1084–88 doi:10.1212/WNL.0b013e3181f39a66 pmid:20855851
    Abstract/FREE Full Text
  15. 15.↵
    1. Rostasy K,
    2. Bajer-Kornek B,
    3. Venkateswaran S, et al
    . Differential diagnosis and evaluation in pediatric inflammatory demyelinating disorders. Neurology 2016;87:S28–37 doi:10.1212/WNL.0000000000002878 pmid:27572858
    Abstract/FREE Full Text
  16. 16.↵
    1. Kim W,
    2. Kim SH,
    3. Lee SH, et al
    . Brain abnormalities as an initial manifestation of neuromyelitis optica spectrum disorder. Mult Scler 2011;17:1107–12 doi:10.1177/1352458511404917 pmid:21543554
    CrossRefPubMed
  17. 17.↵
    1. Wingerchuk DM,
    2. Weinshenker BG
    . Neuromyelitis optica. Curr Treat Options Neurol 2008;10:55–66 doi:10.1007/s11940-008-0007-z pmid:18325300
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Lotze TE,
    2. Northrop JL,
    3. Hutton GJ, et al
    . Spectrum of pediatric neuromyelitis optica. Pediatrics 2008;122:e1039–47 doi:10.1542/peds.2007-2758 pmid:18838462
    Abstract/FREE Full Text
  19. 19.↵
    1. Matsushita T,
    2. Isobe N,
    3. Matsuoka T, et al
    . Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. Mult Scler 2009;15:1113–17 doi:10.1177/1352458509106613 pmid:19625334
    CrossRefPubMed
  20. 20.↵
    1. Banwell B,
    2. Tenembaum S,
    3. Lennon VA, et al
    . Neuromyelitis optica-IgG in childhood inflammatory demyelinating CNS disorders. Neurology 2008;70:344–52 doi:10.1212/01.wnl.0000284600.80782.d5 pmid:18094334
    Abstract/FREE Full Text
  21. 21.↵
    1. Kremer L,
    2. Mealy M,
    3. Jacob A, et al
    . Brainstem manifestations in neuromyelitis optica: a multicenter study of 258 patients. Mult Scler 2014;20:843–47 doi:10.1177/1352458513507822 pmid:24099751
    CrossRefPubMed
  22. 22.↵
    1. Peña JA,
    2. Ravelo ME,
    3. Mora-La Cruz E, et al
    . NMO in pediatric patients: brain involvement and clinical expression. Arq Neuropsiquiatr 2011;69:34–38 doi:10.1590/S0004-282X2011000100008 pmid:21359420
    CrossRefPubMed
  23. 23.↵
    1. Marin SE,
    2. Callen DJ
    . The magnetic resonance imaging appearance of monophasic acute disseminated encephalomyelitis: an update post application of the 2007 consensus criteria. Neuroimaging Clin N Am 2013;23:245–66 doi:10.1016/j.nic.2012.12.005 pmid:23608688
    CrossRefPubMed
  24. 24.↵
    1. Orman G,
    2. Wang KY,
    3. Pekcevik Y, et al
    . Enhancing brain lesions during acute optic neuritis and/or longitudinally extensive transverse myelitis may portend a higher relapse rate in neuromyelitis optica spectrum disorders. AJNR Am J Neuroradiol 2017;38:949–53 doi:10.3174/ajnr.A5141 pmid:28302609
    Abstract/FREE Full Text
  25. 25.↵
    1. Ito S,
    2. Mori M,
    3. Makino T, et al
    . “Cloud-like enhancement” is a magnetic resonance imaging abnormality specific to neuromyelitis optica. Ann Neurol 2009;66:425–28 doi:10.1002/ana.21753 pmid:19798642
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Banker P,
    2. Sonni S,
    3. Kister I, et al
    . Pencil-thin ependymal enhancement in neuromyelitis optica spectrum disorders. Mult Scler 2012;18:1050–53 doi:10.1177/1352458511431730 pmid:22183933
    CrossRefPubMed
  27. 27.↵
    1. Long Y,
    2. Chen M,
    3. Zhang B, et al
    . Brain gadolinium enhancement along the ventricular and leptomeningeal regions in patients with aquaporin-4 antibodies in cerebral spinal fluid. J Neuroimmunol 2014;269:62–67 doi:10.1016/j.jneuroim.2014.02.006 pmid:24582827
    CrossRefPubMed
  28. 28.↵
    1. Pekcevik Y,
    2. Izbudak I
    . Perivascular enhancement in a patient with neuromyelitis optica spectrum disease during an optic neuritis attack. J Neuroimaging 2015;25:686–87 doi:10.1111/jon.12198 pmid:25496413
    CrossRefPubMed
  29. 29.↵
    1. Saiki S,
    2. Ueno Y,
    3. Moritani T, et al
    . Extensive hemispheric lesions with radiological evidence of blood-brain barrier integrity in a patient with neuromyelitis optica. J Neurol Sci 2009;284:217–19 doi:10.1016/j.jns.2009.05.022 pmid:19497587
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Zuccoli G,
    2. Panigrahy A,
    3. Sreedher G, et al
    . Vasogenic edema characterizes pediatric acute disseminated encephalomyelitis. Neuroradiology 2014;56:679–84 doi:10.1007/s00234-014-1379-2 pmid:24854347
    CrossRefPubMed
  31. 31.↵
    1. Narayan R,
    2. Simpson A,
    3. Fritsche K, et al
    . MOG antibody disease: a review of MOG antibody seropositive neuromyelitis optica spectrum disorder. Mult Scler Relat Disord 2018;25:66–72 doi:10.1016/j.msard.2018.07.025 pmid:30048919
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 40 (4)
American Journal of Neuroradiology
Vol. 40, Issue 4
1 Apr 2019
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Brain MRI Findings in Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Challenges in Differentiation from Acute Disseminated Encephalomyelitis
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
E. Bulut, J. Karakaya, S. Salama, M. Levy, T.A.G.M. Huisman, I. Izbudak
Brain MRI Findings in Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Challenges in Differentiation from Acute Disseminated Encephalomyelitis
American Journal of Neuroradiology Apr 2019, 40 (4) 726-731; DOI: 10.3174/ajnr.A6003

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Brain MRI Findings in Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Challenges in Differentiation from Acute Disseminated Encephalomyelitis
E. Bulut, J. Karakaya, S. Salama, M. Levy, T.A.G.M. Huisman, I. Izbudak
American Journal of Neuroradiology Apr 2019, 40 (4) 726-731; DOI: 10.3174/ajnr.A6003
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Challenges in Differentiating Pediatric Autoimmune CNS Diseases with Similar Clinical and Imaging Phenotypes
  • Crossref (4)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • M-DDC: MRI based demyelinative diseases classification with U-Net segmentation and convolutional network
    Deyang Zhou, Lu Xu, Tianlei Wang, Shaonong Wei, Feng Gao, Xiaoping Lai, Jiuwen Cao
    Neural Networks 2024 169
  • Mirror-Image Lesions in Sequential Relapses of AQP4-Positive Neuromyelitis Optica Spectrum Disorder
    Ryan T. Muir, Aditya Bharatha, Dalia Rotstein
    Frontiers in Neurology 2020 11
  • Neuromyelitis optica spectrum disorder complicated with Sjögren’s syndrome: first pediatric case responsive to mycophenolate mofetil treatment
    Gao-Li Fang, Wei Fang, Yang Zheng, Yin-Xi Zhang
    Acta Neurologica Belgica 2021 121 4
  • Challenges in Differentiating Pediatric Autoimmune CNS Diseases with Similar Clinical and Imaging Phenotypes
    B.P. Kelley, P.A. Caruso, P.W. Schaefer
    American Journal of Neuroradiology 2019

More in this TOC Section

  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • ASL in PEDS Nontraumatic Orbital Lesions
Show more Pediatrics

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire