The Association between FLAIR Vascular Hyperintensity and Stroke Outcome Varies with Time from Onset

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Fig 1.
Detailed middle cerebral artery vascular status by symptom-to-MR imaging time, which increases with group number and the presence of FLAIR vascular hyperintensity.
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Fig 2.
Detailed middle cerebral artery signal intensity by symptom-to-MR imaging time, which increases with group number and the presence of FLAIR vascular hyperintensity. A, All M3 branches of the MCA are visualized on the cortical surface. B, One or more M3 branches are not visualized on the cortical surface. C, The superior or inferior trunk of the MCA or ≥1 M2 branch is not visualized along its course. D, M1 branches are not visualized along the course of the MCA.
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Fig 3.
The ASPECTS lesion volume against the distal FLAIR vascular hyperintensity score.

Table 1:

Clinical and demographic patient characteristics by symptom-to-MRI time and the presence of FVH^{^a}

Characteristics	Group 1 (n = 191)			Group 2 (n = 164)			Group 3 (n = 104)
Characteristics	FVH (−) (n = 74)	FVH (+) (n = 117)	P Value	FVH (−) (n = 63)	FVH (+) (n = 101)	P Value	FVH (−) (n = 44)	FVH (+) (n = 60)	P Value
Women	27 (36.5)	37 (31.6)	.53	20 (31.7)	27 (26.7)	.60	10 (22.7)	20 (33.3)	.28
Age (yr)	60.7 ± 14.3	63.9 ± 12.5	.11	66 (46–73)	65.5 (54–74)	.88	55.1 ± 13.7	63.6 ± 11.0	.001^{^b}
Symptom-to-admission time (days)	3 (2–4)	2 (1–4)	.05	5 (4–7)	4 (3–7)	.21	16.5 (12–31)	19.5 (12–30.75)	.79
Risk factors
Hypertension	58 (78.4)	82 (70.1)	.24	35 (55.6)	70 (69.3)	.09	31 (70.5)	45 (75)	.66
Diabetes mellitus	29 (39.2)	28 (23.9)	.03^{^b}	16 (25.4)	36 (35.6)	.23	12 (27.3)	13 (21.7)	.64
Hypercholesterolemia	24 (32.4)	43 (36.8)	.64	24 (38.1)	30 (29.7)	.31	8 (18.2)	8 (13.3)	.59
Smoker	24 (32.4)	52 (44.4)	.13	25 (39.7)	48 (47.5)	.34	19 (43.2)	26 (43.3)	1.00
Coronary heart disease	5 (6.8)	6 (5.1)	.88	1 (1.6)	6 (5.9)	.35	6 (13.6)	5 (8.3)	.59
Atrial fibrillation	4 (5.4)	8 (6.8)	.93	2 (3.2)	1 (1.0)	.88	1 (2.3)	2 (3.3)	1.00
Previous stroke	18 (24.3)	29 (24.8)	1.00	9 (14.3)	25 (24.8)	.12	9 (20.5)	19 (31.7)	.27
NIHSS score at admission	4 (2–7)	6 (3–10)	.02^{^b}	4 (2–9)	5 (2–9)	.32	5 (2–10)	4.5 (2–9)	.56
Hospitalization (days)	10.5 (8–13)	13 (10–16)	.001^{^b}	12 (9–15)	13 (9–15)	.95	13.5 (8–15)	12.5 (9.25–16)	.94
Outcome at discharge
mRS	2 (1–3)	3 (2–4)	<.001^{^b}	2 (1–3)	3 (2–4)	.10	2.5 (1–4)	3 (1.25–4)	.54
mRS ≥ 2	54 (73.0)	100 (85.5)	.04^{^b}	43 (68.3)	85 (84.2)	.02^{^b}	31 (70.5)	45 (75.0)	.66
mRS ≥ 3	31 (41.9)	70 (59.8)	.02^{^b}	29 (46.0)	52 (51.5)	.52	22 (50.0)	34 (56.7)	.55