Risk of Acute Cerebrovascular Events in Patients with COVID-19 Infection

American Journal of Neuroradiology

Summary of patient characteristics

Characteristics	Patients with COVID-19 with Acute CVE (n = 6)	Patients with COVID-19 without Acute CVE (n = 99)	P value
Mean age (yr)	62 ± 14	66 ± 17	0.41^{^a}
< 50 yrs, n (%)	1 (17)	14 (14)	>0.99^{^b}
≥ 50 yrs, n (%)	5 (83)	85 (86)
Sex, n (%)			0.40^{^b}
Male	5 (83)	57 (58)
Female	1 (17)	42 (42)
Indication for neuroimaging, n (%)			0.08^{^c}
Altered mental status	1 (17)	47 (47)
Trauma	1 (17)	24 (24)
Stroke symptoms	4 (67)	14 (14)
Headache	0 (0)	7 (7)
Seizure	0 (0)	3 (3)
Syncope	0 (0)	3 (3)
Dizziness	0 (0)	1 (1)
Comorbidities, n (%)
Current smoker	0 (0)	7 (7)	>0.99^{^b}
Ex-smoker	1 (17)	8 (8)	0.42^{^b}
Hypertension	3 (50)	62 (63)	0.67^{^b}
Diabetes	2 (33)	38 (38)	>0.99^{^b}
Obesity	3 (50)	20 (20)	0.12^{^b}
COPD/asthma/OSA	2 (33)	18 (18)	0.32^{^b}
Malignancy	0 (0)	11 (11)	>0.99^{^b}
Cardiovascular disease	1 (17)	11 (11)	0.53^{^b}
Cerebrovascular disease	0 (0)	7 (7)	>0.99^{^b}
Requiring ICU admission, n (%)	4 (67)	47 (47)	0.43^{^b}
With intubation	3 (50)	42 (42)	>0.99^{^b}
Discharged, n (%)	2 (33)	46 (46)	0.69^{^b}
Deceased, n (%)	2 (33)	11 (11)	0.16

Note:—COPD indicates chronic obstructive pulmonary disease; OSA, obstructive sleep apnea; ICU, intensive care unit.
a Two-tailed t-test.
↵b Fisher's exact test.
↵c Chi-squared test.