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Research ArticleAdult Brain
Open Access

Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS

S. Sacco, E. Caverzasi, N. Papinutto, C. Cordano, A. Bischof, T. Gundel, S. Cheng, C. Asteggiano, G. Kirkish, J. Mallott, W.A. Stern, S. Bastianello, R.M. Bove, J.M. Gelfand, D.S. Goodin, A.J. Green, E. Waubant, M.R. Wilson, S.S. Zamvil, B.A. Cree, S.L. Hauser, R.G. Henry, and and University of California, San Francisco MS-EPIC Team
American Journal of Neuroradiology December 2020, 41 (12) 2219-2226; DOI: https://doi.org/10.3174/ajnr.A6862
S. Sacco
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
bInstitute of Radiology (S.S., C.A.), Department of Clinical Surgical Diagnostic and Pediatric Sciences
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E. Caverzasi
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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N. Papinutto
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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C. Cordano
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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A. Bischof
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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T. Gundel
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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S. Cheng
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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C. Asteggiano
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
bInstitute of Radiology (S.S., C.A.), Department of Clinical Surgical Diagnostic and Pediatric Sciences
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G. Kirkish
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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J. Mallott
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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W.A. Stern
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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S. Bastianello
cDepartment of Brain and Behavioral Sciences (S.B.), University of Pavia, Pavia, Italy
dNeuroradiology Department (S.B.), Istituto Di Ricovero e Cura a Carattere Scientifico Mondino Foundation, Pavia, Italy
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R.M. Bove
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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J.M. Gelfand
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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D.S. Goodin
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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A.J. Green
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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E. Waubant
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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M.R. Wilson
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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S.S. Zamvil
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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B.A. Cree
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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S.L. Hauser
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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R.G. Henry,
aFrom the Department of Neurology (S.S., E.C., N.P., C.C., A.B., T.G., S.C., C.A., G.K., J.M., W.A.S., R.M.B., J.M.G., D.S.G., A.J.G., E.W., M.R.W., S.S.Z, B.A.C., S.L.H., and R.G.H.), University of California, San Francisco Weill Institute for Neurosciences, University of California, San Francisco, California
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    FIG 1.

    A, nODI (ODI pt/ODI HC) values within DAWM, GEL, NAWM, and NGEL masks at baseline with a respective 2-sided t test. Only statistically significant differences are reported (asterisk = P < .05; 2 asterisks = P < .005; 3 asterisks = P < .0005). B, Receiver operating characteristic for logistic regression using nODI for discriminating between GELs and NGELs at baseline. C, NDI values within DAWM, GELs, HCWM, NAWM, and NGELs at baseline with respective 2-sided t-tests. Only statistically significant differences are reported (asterisk = P < .05; 2 asterisks = P < .005; 3 asterisks = P < .0005). pt, subject.

  • FIG 2.
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    FIG 2.

    Lesion type 1 NODDI color map8 graphically representing NDI (green) or VEC (red) compartment prevalence in voxels within a focal WM lesion (white arrows) at baseline (A–C) and at follow-up (after 12 months) (D–F). The green within the lesion is represented more at follow-up, after the disappearance of the enhancement, with a relative decrease of the red voxels. FLAIR sequences (C and F) show an important reduction in size with time. VEC and NDI are fractions in each voxel: If NDI increases, VEC decreases and vice versa. FISO indicates isotropic volume fraction.

  • FIG 3.
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    FIG 3.

    Lesion type 2 NODDI color map8 graphically representing NDI (green) or VEC (red) compartment prevalence in voxels within a focal WM lesion (white arrows) at baseline (A–C) and at follow-up (after 15 months) (D–F). The green within the lesion is less represented at follow-up after the disappearance of the enhancement, with a relative increase of the red voxels. FLAIR sequences (C and F) show a moderate reduction in size with time. VEC and NDI are fractions in each voxel: If NDI decreases, VEC increases and vice versa. FISO indicates isotropic volume fraction.

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American Journal of Neuroradiology: 41 (12)
American Journal of Neuroradiology
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S. Sacco, E. Caverzasi, N. Papinutto, C. Cordano, A. Bischof, T. Gundel, S. Cheng, C. Asteggiano, G. Kirkish, J. Mallott, W.A. Stern, S. Bastianello, R.M. Bove, J.M. Gelfand, D.S. Goodin, A.J. Green, E. Waubant, M.R. Wilson, S.S. Zamvil, B.A. Cree, S.L. Hauser, R.G. Henry,, and University of California, San Francisco MS-EPIC Team
Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS
American Journal of Neuroradiology Dec 2020, 41 (12) 2219-2226; DOI: 10.3174/ajnr.A6862

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Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS
S. Sacco, E. Caverzasi, N. Papinutto, C. Cordano, A. Bischof, T. Gundel, S. Cheng, C. Asteggiano, G. Kirkish, J. Mallott, W.A. Stern, S. Bastianello, R.M. Bove, J.M. Gelfand, D.S. Goodin, A.J. Green, E. Waubant, M.R. Wilson, S.S. Zamvil, B.A. Cree, S.L. Hauser, R.G. Henry,, and University of California, San Francisco MS-EPIC Team
American Journal of Neuroradiology Dec 2020, 41 (12) 2219-2226; DOI: 10.3174/ajnr.A6862
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