Article Figures & Data
Figures
- FIG 1.
MR imaging of a 34-year-old female patient with symptoms of acute optic neuritis of the left eye with loss of vision and pain during eye movement for 3 days. Images of a contrast-enhanced 2D T1-weighted Dixon sequence with coronal orientation (left) and a contrast-enhanced 3D T1-weighted BB sequence with coronal reconstruction (right) are shown. Note a contrast-enhancing lesion in the left optic nerve in the intraorbital section with similarly high contrast in both sequences (arrows).
- FIG 2.
MR imaging of a 27-year-old female patient with symptoms of acute optic neuritis of the right eye with retrobulbar pain and loss of vision for 4 days. Images of a contrast-enhanced 3D T1-weighted Dixon sequence are shown in the upper row, and contrast-enhanced 3D T1-weighted BB images, in the lower row with coronal, axial, and sagittal reconstructions. Note the enhancing lesion in the right optic nerve in the extraorbital section (arrows) with improved contrast depiction in the contrast-enhanced 3D T1-weighted BB sequence compared with the contrast-enhanced 3D T1-weighted Dixon imaging.
Tables
Sequence T1-Weighted BB T1-Weighted Dixon T1-Weighted Dixon Sequence type TSE TFE TSE Acquisition mode 3D 3D 2D Acquisition plane Sagittal Axial Coronal Acquired voxel size (mm3) 0.90 × 0.89 × 0.90 0.90 × 0.99 × 0.90 0.60 × 0.72 ×2.5 Acquisition matrix 280 × 281 132 × 157 200 × 210 FOV (mm) 240 154 151 TR (ms) 700 6.2 500 TE (ms) 35 0 9.8 Acquisition time (min) 1:36 3:11 2:00 Average delay after IV administration of gadolinium (min:sec) 8:42 12:46 13:36 Final Diagnosis “Acute ON”a CE + (Reader 1/Reader 2) CE – (Reader 1/Reader 2) ON+ 21/21 9/9 ON– 0/2 21/19 Note:—CE + indicates contrast enhancement; CE −, no contrast enhancement; ON+, optic neuritis; ON–, no optic neuritis.
↵a Reader 1: sensitivity, 21/30 = 70%; specificity, 21/21 = 100%; reader 2: sensitivity, 21/30 = 70%; specificity, 19/21 = 90%.
- Table 3:
Contingency table of all available diagnostics and the correlation of their results to contrast-enhancing lesions in MR imaging
Diagnosis ON Other Diagnoses Diagnostics (availability) CE+ CE– CE+ CE– VEP (37/51) + 11 3 0 0 – 1 3 0 19 OCT (31/51) + (Acute) 3 2 0 0 + (Chronic) 4 2 0 1 – 4 4 0 11 Note:—CE+ indicates contrast enhancement; CE–, no contrast enhancement; +, pathological; –, normal.
Assessment T1-Weighted BB (Mean) (95% CI) T1-Weighted Dixon (Mean) (95% CI) P (Intrareader Comparison) Overall image quality Reader 1 4.33 ± 0.71 (4.05–4.50) 4.45 ± 0.58 (4.25–4.58) .36 Reader 2 4.22 ± 0.64 (3.98–4.36) 4.06 ± 0.58 (3.86–4.19) .07 Mean 4.27 ± 0.68 (4.05–4.41) 4.25 ± 0.61 (4.13–4.40) .81 Artifacts Reader 1 4.25 ± 0.69 (3.98–4.41) 4.57 ± 0.57 (4.36–4.71) .01b Reader 2 4.25 ± 0.72 (3.97–4.42) 4.16 ± 0.76 (3.86–4.30) .20 Mean 4.25 ± 0.70 (4.03–4.39) 4.36 ± 0.70 (4.17–4.49) 0.17 Diagnostic confidence Reader 1 4.22 ± 1.00 (3.70–4.43) 4.24 ± 0.74 (3.96–4.39) .90 Reader 2 4.41 ± 0.80 (4.08–4.59) 3.96 ± 0.94 (3.55–4.14) < 0.001b Mean 4.31 ± 0.91 (3.98–4.49) 4.10 ± 0.85 (3.86–4.24) .04 Visual contrast enhancement Reader 1 1.92 ± 1.23 (1.35–1.89) 1.92 ± 1.21 (1.36–1.89) 1.00 Reader 2 1.84 ± 1.08 (1.36–1.84) 1.71 ± 0.90 (1.36–1.73) .007b Mean 1.88 ± 1.15 (1.36–1.87) 1.81 ± 1.07 (1.35–1.82) 0.11
